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公开(公告)号:US09943401B2
公开(公告)日:2018-04-17
申请号:US12384659
申请日:2009-04-06
申请人: Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfarlane , Douglas Sutton , John Anthony Scholl
发明人: Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfarlane , Douglas Sutton , John Anthony Scholl
CPC分类号: A61F2/142 , A61F2/14 , A61F9/00 , A61F2250/0067 , G02C7/047
摘要: A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.
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公开(公告)号:US20170051500A1
公开(公告)日:2017-02-23
申请号:US15293401
申请日:2016-10-14
申请人: Stephen Boyd , Joseph Accetta
发明人: Stephen Boyd , Joseph Accetta
IPC分类号: E04B1/41
CPC分类号: E04B1/4114 , E01C23/04 , E04B1/41 , E04B1/48 , E04B1/483 , E04C5/161 , E04G21/185
摘要: A dowel supporting device that includes a substantially hollow tube having a top end and a bottom end. An opening may be formed at the top end and a base may be formed at the bottom end. The base of the dowel supporting device may be fastened to a concrete deck. Concrete may be poured into the concrete deck. When dowels are ready to be used, the dowels may be inserted and secured to the dowel supporting device.
摘要翻译: 一种定位销支撑装置,其包括具有顶端和底端的基本中空的管。 可以在顶端形成开口,并且底部可以形成在底端。 销钉支撑装置的底座可以固定在混凝土板上。 混凝土可以倒入混凝土甲板。 当销钉准备使用时,销钉可以插入并固定到销钉支撑装置。
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公开(公告)号:US09125735B2
公开(公告)日:2015-09-08
申请号:US12897131
申请日:2010-10-04
CPC分类号: A61F9/007 , A61F2/142 , A61F2/1451 , A61F2/1453 , A61F9/0017 , A61F2250/0019
摘要: A corneal onlay is configured to adhere to the cornea so as to inhibit epithelial growth under the onlay. Structures can be provided on the onlay to adhere the onlay to the eye. At least one of an epithelial layer or the water inhibiting layer can be provided on or over the onlay, for example a natural epithelial layer or water inhibiting layer that inhibits, for example minimizes, water penetration into the onlay, so as to adhere the onlay to the eye with pumping of the endothelium. The water inhibiting layer may comprise a therapeutic covering positioned over the onlay to inhibit swelling of the cornea. The posterior surface of the onlay may be shaped so as to fit the anterior exposed surface of the cornea.
摘要翻译: 角膜镶嵌被配置成粘附在角膜上,以便抑制覆盖物下的上皮生长。 可以在镶嵌上提供结构以将贴面粘附到眼睛上。 上皮层或水分抑制层中的至少一个可以设置在覆盖物上或上方,例如天然上皮层或水分抑制层,其抑制例如使水渗入到镶嵌物中的最小程度,以便粘附该覆盖层 通过泵送内皮到眼睛。 防水层可以包括定位在覆层上的治疗覆盖物,以抑制角膜的肿胀。 垫片的后表面可以被成形为适合角膜的前暴露表面。
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公开(公告)号:US20150133878A1
公开(公告)日:2015-05-14
申请号:US14600505
申请日:2015-01-20
申请人: Eugene de Juan, JR. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton , Alexander J. Gould
发明人: Eugene de Juan, JR. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton , Alexander J. Gould
CPC分类号: A61F9/0017 , A61B17/00234 , A61K9/0051 , A61K47/34 , A61L27/025 , A61L27/16
摘要: A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.
摘要翻译: 舒适的插入物包括保持结构,其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。 保留结构在放置在眼结膜囊中时抵抗偏转,并且当眼睛移动时沿着囊引导插入物。 保持结构可以以许多方式构造以提供对偏转的抵抗力,并且可以包括环箍强度,以便向外推动保持结构并阻止保持结构朝向角膜的移动。 插入件可以沿着结膜囊的偏转而旋转移动,并且可以包括保持结构,该保持结构具有尺寸适合于结膜折叠的横截面尺寸。 插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。
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公开(公告)号:US08939948B2
公开(公告)日:2015-01-27
申请号:US13618052
申请日:2012-09-14
申请人: Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton , Alexander J. Gould
发明人: Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton , Alexander J. Gould
CPC分类号: A61F9/0017 , A61B17/00234 , A61K9/0051 , A61K47/34 , A61L27/025 , A61L27/16
摘要: A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.
摘要翻译: 舒适的插入物包括保持结构,其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。 保留结构在放置在眼结膜囊中时抵抗偏转,并且当眼睛移动时沿着囊引导插入物。 保持结构可以以许多方式构造以提供对偏转的抵抗力,并且可以包括环箍强度,以便向外推动保持结构并阻止保持结构朝向角膜的移动。 插入件可以沿着结膜囊的偏转而旋转移动,并且可以包括保持结构,该保持结构具有尺寸适合于结膜折叠的横截面尺寸。 插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。
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公开(公告)号:US08628792B2
公开(公告)日:2014-01-14
申请号:US13367823
申请日:2012-02-07
申请人: Deepank Utkhede , Robert W. Shimizu , Rachna Jain , Stephen Boyd , Hanson S. Gifford , Eugene De Juan, Jr. , Cary J. Reich
发明人: Deepank Utkhede , Robert W. Shimizu , Rachna Jain , Stephen Boyd , Hanson S. Gifford , Eugene De Juan, Jr. , Cary J. Reich
CPC分类号: A61K9/0051 , A61F9/0017 , A61F9/00772 , A61F2230/0069 , A61F2250/0067 , A61K31/5575 , A61K47/34 , A61L27/54 , A61L2300/41 , A61L2300/602 , A61L2300/802 , Y02A50/395
摘要: A solid drug core insert can be manufactured by injecting a liquid mixture comprising a therapeutic agent and a matrix precursor into a sheath body. The injection can be conducted at subambient temperatures. The mixture is cured to form a solid drug-matrix core. The therapeutic agent can be a liquid at about room temperature that forms a dispersion of droplets in the matrix material. A surface of the solid drug core is exposed, for example by cutting the tube, and the exposed surface of the solid drug core releases therapeutic quantities of the therapeutic agent when implanted into the patient. In some embodiments, the insert body inhibits release of the therapeutic agent, for example with a material substantially impermeable to the therapeutic agent, such that the therapeutic quantities are released through the exposed surface, thereby avoiding release of the therapeutic agent to non-target tissues.
摘要翻译: 可以通过将包含治疗剂和基质前体的液体混合物注入鞘体来制造固体药物核心插入物。 注射可以在低于环境温度下进行。 将混合物固化以形成固体药物基质核心。 治疗剂可以是在约室温下的液体,其形成液滴在基质材料中的分散体。 固体药物核心的表面例如通过切割管而暴露,并且固体药物核心的暴露表面在植入患者体内释放治疗剂量。 在一些实施方案中,插入体抑制治疗剂的释放,例如具有对治疗剂基本上不可渗透的材料,使得治疗量通过暴露表面释放,从而避免将治疗剂释放到非靶组织 。
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公开(公告)号:US20130144128A1
公开(公告)日:2013-06-06
申请号:US13618052
申请日:2012-09-14
申请人: Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton
发明人: Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton
IPC分类号: A61B17/00
CPC分类号: A61F9/0017 , A61B17/00234 , A61K9/0051 , A61K47/34 , A61L27/025 , A61L27/16
摘要: A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.
摘要翻译: 舒适的插入物包括保持结构,其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。 保留结构在放置在眼结膜囊中时抵抗偏转,并且当眼睛移动时沿着囊引导插入物。 保持结构可以以许多方式构造以提供对偏转的抵抗力,并且可以包括环箍强度,以便向外推动保持结构并阻止保持结构朝向角膜的移动。 插入件可以沿着结膜囊的偏转而旋转移动,并且可以包括保持结构,该保持结构具有尺寸适合于结膜折叠的横截面尺寸。 插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。
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公开(公告)号:US20120233024A1
公开(公告)日:2012-09-13
申请号:US13210235
申请日:2011-08-15
申请人: Stephen Boyd
发明人: Stephen Boyd
CPC分类号: G06Q30/0207
摘要: In accordance with aspects of the disclosure, a method, apparatus, and computer program product are provided for wireless communication. The method, apparatus, and computer program product may be configured to reference moving positional points within a defined proximity and search a parameter based on the moving positional points. The defined proximity may comprise a region of influence defined by a radial distance from each of the moving positional points.
摘要翻译: 根据本公开的方面,提供了一种用于无线通信的方法,装置和计算机程序产品。 方法,装置和计算机程序产品可以被配置为参考在所定义的接近度内的移动位置点,并且基于移动的位置点来搜索参数。 所定义的接近度可以包括由距每个移动位置点的径向距离限定的影响区域。
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公开(公告)号:US20120168422A1
公开(公告)日:2012-07-05
申请号:US13420499
申请日:2012-03-14
申请人: Stephen Boyd , Cary Reich
发明人: Stephen Boyd , Cary Reich
IPC分类号: H05B7/18
CPC分类号: B29D11/023 , A61F2/1635 , A61F2240/001 , B23K26/0624 , B23K2103/42 , B23K2103/50 , B29D11/00461
摘要: An intraocular lens comprises an optical element adapted to be implanted within the capsular bag of a human eye. The optical element includes one or more internal layers formed by one or more planes that are moveable relative to one another in order to effect the power of the optical element.
摘要翻译: 眼内透镜包括适于植入人眼的囊袋内的光学元件。 光学元件包括由相对于彼此可移动的一个或多个平面形成的一个或多个内层,以便实现光学元件的功率。
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公开(公告)号:US20110098629A1
公开(公告)日:2011-04-28
申请号:US12970482
申请日:2010-12-16
IPC分类号: A61F9/00
CPC分类号: A61F9/00781 , A61B34/70 , A61B90/00 , A61F2/14 , A61F2/142 , A61F9/0008 , A61F9/0017 , A61F9/007 , A61F9/00736 , A61F9/0133 , A61F11/00 , A61F2250/0001 , A61F2250/0096 , A61F2250/0097 , A61K9/0051 , A61M27/002 , A61M2202/04 , A61M2210/0612
摘要: Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.
摘要翻译: 方法和装置适于植入眼睛。 在眼睛的角膜中形成切口,并且通过切口将分路插入眼睛的前房。 分流器包括流体通道。 所述分流器沿着从所述前房通过所述眼睛的巩膜刺入所述脉管外空间的路径通过并且定位在第一位置,使得所述流体通道的第一部分与所述前房连通,并且所述流体通道的第二部分 与脉管外空间连通,以在脉络膜上空间和前房之间提供流体通道。
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