公开(公告)号：US20100324023A1

公开(公告)日：2010-12-23

申请号：US12867332

申请日：2009-02-06

申请人： Howard G. Selnick ,  Ian M. Bell

发明人： Howard G. Selnick ,  Ian M. Bell

IPC分类号： A61K31/55 ,  C07D487/14 ,  C07D498/20 ,  A61P25/06

CPC分类号： C07D519/00 ,  C07D487/14

摘要： Compounds of Formula I: I (where variables R1A, R1B, R2, R3, R4, A, and Z are as defined herein) useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.

摘要翻译： 式I化合物（其中变量R1A，R1B，R2，R3，R4，A和Z如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP受体的疾病 ，如头痛，尤其是偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP受体的疾病中的用途。

公开(公告)号：US20100152216A1

公开(公告)日：2010-06-17

申请号：US12530898

申请日：2008-03-07

申请人： Craig A. Stump ,  Ian M. Bell ,  Harold G. Selnick

发明人： Craig A. Stump ,  Ian M. Bell ,  Harold G. Selnick

IPC分类号： A61K31/513 ,  C07D403/12 ,  A61K31/4184 ,  C07D471/10 ,  A61K31/437 ,  A61P25/06 ,  C07D491/107 ,  C07D471/20

CPC分类号： C07D471/20 ,  C07D403/12 ,  C07D471/10 ,  C07D519/00

摘要： The present invention is directed to compounds of Formula I: (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式I化合物（其中变量A1，A2，B，J，K，m，n，R4，R5a，R5b和R5c如本文所定义）可用作CGRP受体的拮抗剂，并且可用于 治疗或预防CGRP涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US07659300B2

公开(公告)日：2010-02-09

申请号：US11660821

申请日：2005-09-06

申请人： Ian M. Bell ,  Craig A. Stump

发明人： Ian M. Bell ,  Craig A. Stump

IPC分类号： A61K31/4015 ,  C07D209/54

CPC分类号： C07D471/04 ,  C07D209/96 ,  C07D487/04

摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及用作CGRP受体的拮抗剂的式I化合物：其中A1（A2，B，J，K，m，n，R4，R5a，R5b和R5c如本文所定义） 治疗或预防CGRP涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US06410534B1

公开(公告)日：2002-06-25

申请号：US09347673

申请日：1999-06-29

申请人： Christopher J. Dinsmore ,  Ian M. Bell ,  Douglas C. Beshore ,  Theresa M. Williams

发明人： Christopher J. Dinsmore ,  Ian M. Bell ,  Douglas C. Beshore ,  Theresa M. Williams

IPC分类号： A61K314188

CPC分类号： C07D498/04 ,  A61K31/415 ,  A61K31/335 ,  A61K2300/00

摘要： The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

公开(公告)号：US5691323A

公开(公告)日：1997-11-25

申请号：US440153

申请日：1995-05-12

申请人： Wayne J. Thompson ,  Michael F. Sugrue ,  Richard W. Ransom ,  Pierre J. Mallorga ,  Ian M. Bell ,  Anthony M. Smith

发明人： Wayne J. Thompson ,  Michael F. Sugrue ,  Richard W. Ransom ,  Pierre J. Mallorga ,  Ian M. Bell ,  Anthony M. Smith

IPC分类号： C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  A61K31/38 ,  A61K31/34 ,  C07D403/14

CPC分类号： C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

摘要： Compounds, 1,3-dihydro-1-{1-�piperidin-4-yl!piperidin-4-yl}-2H-benzimidazol-2-ones and 1,3-dihydro-1-{4-amino-1-cyclohexyl}-2H-benzimidazol-2-ones and derivatives thereof, their preparation, method of use and pharmaceutical compositions are described. These compounds are endowed with antimuscarinic activity and are useful in the treatment and/or prevention of myopia (commonly known as nearsightedness).

摘要翻译： 化合物，1,3-二氢-1- {1- [哌啶-4-基]哌啶-4-基} -2H-苯并咪唑-2-酮和1,3-二氢-1- {4-氨基-1- 环己基} -2H-苯并咪唑-2-酮及其衍生物，其制备方法，使用方法和药物组合物。 这些化合物具有抗毒蕈碱活性，可用于治疗和/或预防近视（俗称近视）。

公开(公告)号：US20230227405A1

公开(公告)日：2023-07-20

申请号：US18009310

申请日：2021-06-14

申请人： Ashok ARASAPPAN ,  Ian M. BELL ,  Jason M. COX ,  Michael J. KELLY, III ,  Mark E. LAYTON ,  Hong LIU ,  Jian LIU ,  Akshay A. SHAH ,  Michael D. VANHEYST ,  MERCK SHARP & DOHME CORP.

发明人： Ashok Arasappan ,  Ian M. Bell ,  Jason Michael Cox ,  Michael J. Kelly, III ,  Mark E. Layton ,  Hong Liu ,  Jian Liu ,  Akshay A. Shah ,  Michael David VanHeyst

IPC分类号： C07D207/277 ,  C07D401/12 ,  C07D417/12

CPC分类号： C07D207/277 ,  C07D401/12 ,  C07D417/12

摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

公开(公告)号：US08685965B2

公开(公告)日：2014-04-01

申请号：US13121784

申请日：2009-09-29

申请人： Donnette D. Staas ,  Ian M. Bell ,  Harold G. Selnick

发明人： Donnette D. Staas ,  Ian M. Bell ,  Harold G. Selnick

IPC分类号： A61K31/537

CPC分类号： C07D498/20 ,  C07D498/04 ,  C07D498/10

摘要： Compounds of Formula (I), (wherein variables A1, A2, A3, A4, A5, A6, A7, A8, L, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG, W, Y and Z are as described herein) useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.

摘要翻译： 式（I）化合物（其中变量A1，A2，A3，A4，A5，A6，A7，A8，L，J，Q，R4，Ea，Eb，Ec，R6，R7，Re，Rf， W，Y和Z如本文所述）可用作CGRP受体的拮抗剂，并且可用于治疗或预防涉及CGRP受体的疾病，例如头痛，特别是偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP受体的疾病中的用途。

公开(公告)号：US20140011827A1

公开(公告)日：2014-01-09

申请号：US14005673

申请日：2012-03-14

申请人： Ian M. Bell ,  Justin Belardi

发明人： Ian M. Bell ,  Justin Belardi

IPC分类号： C07D487/10

CPC分类号： C07D487/10 ,  C07D471/10

摘要： The present invention is directed to piperidinone carboxamide spirohydantoin derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

公开(公告)号：US20140005214A1

公开(公告)日：2014-01-02

申请号：US14005595

申请日：2012-03-14

申请人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Helen J. Mitchell ,  Cheng Wang

发明人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Helen J. Mitchell ,  Cheng Wang

IPC分类号： C07D401/12

CPC分类号： C07D401/12 ,  A61K31/445

摘要： The present invention is directed to piperidinone carboxamide spirohydantoin derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮甲酰胺螺乙内酰脲衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US08507477B2

公开(公告)日：2013-08-13

申请号：US13059164

申请日：2009-08-14

申请人： Michael R. Wood ,  Ian M. Bell ,  June J. Kim ,  Harold G. Selnick ,  Craig A. Stump

发明人： Michael R. Wood ,  Ian M. Bell ,  June J. Kim ,  Harold G. Selnick ,  Craig A. Stump

IPC分类号： C07D487/10 ,  A61K31/55 ,  A61P25/06

CPC分类号： C07D471/20

摘要： Compounds of Formula (I): (where variables R1A, R1B, R2, R3, R4, A, and Z are as defined herein) which are useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.

摘要翻译： 式（I）的化合物（其中变量R1A，R1B，R2，R3，R4，A和Z如本文所定义），其可用作CGRP受体的拮抗剂，并且可用于治疗或预防CGRP 涉及受体，例如头痛，特别是偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP受体的疾病中的用途。