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公开(公告)号:US6165786A
公开(公告)日:2000-12-26
申请号:US433699
申请日:1999-11-03
申请人: C. Frank Bennett , Lex M. Cowsert
发明人: C. Frank Bennett , Lex M. Cowsert
CPC分类号: C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要: Antisense compounds, compositions and methods are provided for inhibiting the expression of Nucleolin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Nucleolin. Methods of using these compounds for modulation of Nucleolin expression and for treatment of diseases associated with expression of Nucleolin are provided.
摘要翻译: 提供反义化合物,组合物和方法用于抑制Nucleolin的表达。 组合物包含靶向编码Nucleolin的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节核林素表达和治疗与Nucleolin表达有关的疾病的方法。
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公开(公告)号:US06165728A
公开(公告)日:2000-12-26
申请号:US444053
申请日:1999-11-19
申请人: Donna T. Ward , Lex M. Cowsert
发明人: Donna T. Ward , Lex M. Cowsert
IPC分类号: A61K38/00 , C12N15/113 , C07H21/04 , C12N15/85 , C12Q1/68
CPC分类号: C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of nck-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding nck-2. Methods of using these compounds for modulation of nck-2 expression and for treatment of diseases associated with expression of nck-2 are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节nck-2的表达。 组合物包含靶向编码nck-2的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节nck-2表达和治疗与nck-2表达相关的疾病的方法。
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公开(公告)号:US6159697A
公开(公告)日:2000-12-12
申请号:US487444
申请日:2000-01-09
申请人: Brett P. Monia , Lex M. Cowsert
发明人: Brett P. Monia , Lex M. Cowsert
IPC分类号: C12N15/09 , A61K31/711 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P9/00 , A61P17/02 , A61P35/00 , A61P43/00 , C12N15/113 , C12Q1/68
CPC分类号: C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of Smad7. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Smad7. Methods of using these compounds for modulation of Smad7 expression and for treatment of diseases associated with expression of Smad7 are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节Smad7的表达。 组合物包含靶向编码Smad7的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节Smad7表达和治疗与Smad7表达有关的疾病的方法。
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公开(公告)号:US6130088A
公开(公告)日:2000-10-10
申请号:US358384
申请日:1999-07-21
申请人: Brett P. Monia , Lex M. Cowsert
发明人: Brett P. Monia , Lex M. Cowsert
IPC分类号: C12N15/09 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P35/00 , A61P43/00 , C12N15/113 , C07H21/04 , C12N15/85 , C12Q1/68
CPC分类号: C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of Telomeric Repeat Binding Factor 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Telomeric Repeat Binding Factor 1. Methods of using these compounds for modulation of Telomeric Repeat Binding Factor 1 expression and for treatment of diseases associated with expression of Telomeric Repeat Binding Factor 1 are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节端粒重复结合因子1的表达。组合物包含靶向编码端粒重复结合因子1的核酸的反义化合物,特别是反义寡核苷酸。使用这些化合物调节端粒重复的方法 提供了绑定因子1表达和治疗与端粒重复结合因子1表达相关的疾病。
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公开(公告)号:US6046049A
公开(公告)日:2000-04-04
申请号:US357070
申请日:1999-07-19
申请人: Brett P. Monia , Lex M. Cowsert
发明人: Brett P. Monia , Lex M. Cowsert
IPC分类号: C12N15/09 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P11/06 , A61P19/02 , A61P29/00 , A61P43/00 , C12N15/113 , C07H21/04 , C12N15/00 , C12Q1/68
CPC分类号: C12N15/1137 , C12Y207/01137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of PI3 kinase p110 delta. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PI3 kinase p110 delta. Methods of using these compounds for modulation of PI3 kinase p110 delta expression and for treatment of diseases associated with expression of PI3 kinase p110 delta are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节PI3激酶p110δ的表达。 组合物包含靶向编码PI3激酶p110δ的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节PI3激酶p110δ表达和治疗与PI3激酶p110δ表达相关的疾病的方法。
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公开(公告)号:US6043091A
公开(公告)日:2000-03-28
申请号:US357071
申请日:1999-07-19
申请人: Brett P. Monia , Lex M. Cowsert
发明人: Brett P. Monia , Lex M. Cowsert
IPC分类号: C12N15/09 , A61K9/10 , A61K31/711 , A61K45/00 , A61P3/10 , A61P43/00 , C07H21/00 , C12N9/10 , C12N9/99 , C07H21/04 , C12N15/85 , C12Q1/68
CPC分类号: C07H21/00 , C12N9/1051 , C07B2200/11 , Y02P20/582
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of liver glycogen phosphorylase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding liver glycogen phosphorylase. Methods of using these compounds for modulation of liver glycogen phosphorylase expression and for treatment of diseases associated with expression of liver glycogen phosphorylase are provided.
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公开(公告)号:US6007995A
公开(公告)日:1999-12-28
申请号:US106038
申请日:1998-06-26
申请人: Brenda F. Baker , Lex M. Cowsert
发明人: Brenda F. Baker , Lex M. Cowsert
IPC分类号: A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113 , C07H21/04 , C12N15/11 , C12N15/85 , C12Q1/68
CPC分类号: C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/335 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of TNFR1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TNFR1. Methods of using these compounds for modulation of TNFR1 expression and for treatment of diseases associated with expression of TNFR1 are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节TNFR1的表达。 组合物包含靶向编码TNFR1的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节TNFR1表达和治疗与TNFR1表达相关的疾病的方法。
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公开(公告)号:US5981732A
公开(公告)日:1999-11-09
申请号:US205860
申请日:1998-12-04
申请人: Lex M. Cowsert
发明人: Lex M. Cowsert
IPC分类号: A61K38/00 , C12N15/113 , C07H21/04 , C12Q1/68
CPC分类号: C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/318 , C12N2310/3181 , C12N2310/321 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of G-alpha-13. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding G-alpha-13. Methods of using these compounds for modulation of G-alpha-13 expression and for treatment of diseases associated with expression of G-alpha-13 are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节G-α-13的表达。 组合物包含靶向编码G-α-13的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节G-α-13表达和治疗与G-α-13表达有关的疾病的方法。
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公开(公告)号:US5965370A
公开(公告)日:1999-10-12
申请号:US161015
申请日:1998-09-25
申请人: Lex M. Cowsert
发明人: Lex M. Cowsert
CPC分类号: C12N15/1137 , C12Y301/05001 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/334 , C12N2310/335 , C12N2310/341 , C12N2310/346
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of RhoG. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding RhoG. Methods of using these compounds for modulation of RhoG expression and for treatment of diseases associated with expression of RhoG are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节RhoG的表达。 组合物包含靶向编码RhoG的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节RhoG表达和治疗与RhoG表达相关的疾病的方法。
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公开(公告)号:US5872242A
公开(公告)日:1999-02-16
申请号:US889296
申请日:1997-07-08
IPC分类号: C12N15/09 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P35/00 , C07K14/82 , C12N15/113 , C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号: C12N15/1135 , C07K14/82 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/3521 , C12N2310/3527 , C12N2310/3533 , C12Q2525/125
摘要: Compositions and methods are provided for the modulation of ras expression. Oligonucleotides are provided which are targeted to nucleic acids encoding human ras. Oligonucleotides specifically hybridizable with mRNA encoding human H-ras, Ki-ras and N-ras are provided. Such oligonucleotides can be used for therapeutics and diagnostics as well as for research purposes. Methods are also disclosed for modulating ras gene expression in cells and tissues using the oligonucleotides provided, and for specific modulation of expression of activated ras. Methods for diagnosis, detection and treatment of conditions associated with ras are also disclosed.
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