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公开(公告)号：US20150361104A1
公开(公告)日：2015-12-17
申请号：US14765152
申请日：2014-01-31
申请人： Tsutomu AKAMA , Eric EASOM , Yvonne FREUND , Jacob J. PLATTNER , Jessica SLIGAR , Daitao CHEN , Jennifer FREEMAN , Joe PERALES , ANACOR PHARMACEUTICALS, INC.
发明人： Tsutomu AKAMA , Eric Easom , Yvonne Freund , Jacob J. Plattner , Jessica Sligar , Daitao Chen , Jennifer Freeman , Joe Perales
摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
摘要翻译： 本发明尤其提供了可用于治疗原生动物感染的新化合物，含有这些化合物的药物组合物，以及这些化合物与至少一种另外的治疗有效药物的组合。
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公开(公告)号：US08623911B2
公开(公告)日：2014-01-07
申请号：US13636114
申请日：2011-03-18
申请人： Robert T. Jacobs , Daitao Chen , Matthew Orr , Jacob J. Plattner
发明人： Robert T. Jacobs , Daitao Chen , Matthew Orr , Jacob J. Plattner
摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
摘要翻译： 本发明尤其提供了可用于治疗原生动物感染的新化合物，含有这些化合物的药物组合物，以及这些化合物与至少一种另外的治疗有效药物的组合。
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公开(公告)号：US08470803B2
公开(公告)日：2013-06-25
申请号：US13062466
申请日：2009-09-10
申请人： Tsutomu Akama , Jacob J. Plattner
发明人： Tsutomu Akama , Jacob J. Plattner
CPC分类号： C07F5/025
摘要： This invention provides, among other things, novel compounds useful for treating inflammatory conditions, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
摘要翻译： 本发明尤其提供了可用于治疗炎性病症的新化合物，含有这些化合物的药物组合物，以及这些化合物与至少一种另外的治疗有效药物的组合。
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公开(公告)号：US08461134B2
公开(公告)日：2013-06-11
申请号：US12944690
申请日：2010-11-11
申请人： Vincent S. Hernandez , Xianfeng Li , Suoming Zhang , Tsutomu Akama , Yanchen Zhang , Yang Liu , Jacob J. Plattner , Michael Richard Kevin Alley , Yasheen Zhou , James A. Nieman
发明人： Vincent S. Hernandez , Xianfeng Li , Suoming Zhang , Tsutomu Akama , Yanchen Zhang , Yang Liu , Jacob J. Plattner , Michael Richard Kevin Alley , Yasheen Zhou , James A. Nieman
CPC分类号： C07F5/025
摘要： This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
摘要翻译： 本发明涉及6-取代的苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号：US20130059803A1
公开(公告)日：2013-03-07
申请号：US13607321
申请日：2012-09-07
申请人： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
发明人： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
IPC分类号： A61K31/69 , A61P31/10 , A61K31/7028
CPC分类号： C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号：US20120115813A1
公开(公告)日：2012-05-10
申请号：US13227444
申请日：2011-09-07
申请人： Vincent S. Hernandez , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
发明人： Vincent S. Hernandez , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
CPC分类号： C07F5/025
摘要： This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.
摘要翻译： 本发明涉及苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号：US08115026B2
公开(公告)日：2012-02-14
申请号：US12629753
申请日：2009-12-02
申请人： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Steven J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
发明人： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Steven J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
IPC分类号： C07F5/04
CPC分类号： C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译： 本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物，并具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，毛发，爪或蹄特定部位的性质。 特别地，本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号：US20110212918A1
公开(公告)日：2011-09-01
申请号：US12944699
申请日：2010-11-11
申请人： Vincent S. Hernandez , Xianfeng Li , Suoming Zhang , Tsutomu Akama , Yanchen Zhang , Yang Liu , Jacob J. Plattner , Michael Richard Kevin Alley , Yasheen Zhou , James A. Nieman
发明人： Vincent S. Hernandez , Xianfeng Li , Suoming Zhang , Tsutomu Akama , Yanchen Zhang , Yang Liu , Jacob J. Plattner , Michael Richard Kevin Alley , Yasheen Zhou , James A. Nieman
CPC分类号： C07F5/025
摘要： This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
摘要翻译： 本发明涉及6-取代的苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号：US20110207701A1
公开(公告)日：2011-08-25
申请号：US12857305
申请日：2010-08-16
申请人： Huchen Zhou , Dazhong Ding , Yasheen Zhou , Yong-Kang Zhang , Jacob J. Plattner
发明人： Huchen Zhou , Dazhong Ding , Yasheen Zhou , Yong-Kang Zhang , Jacob J. Plattner
CPC分类号： C07F5/025
摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
摘要翻译： 本发明尤其提供了可用于治疗原生动物感染的新化合物，含有这些化合物的药物组合物，以及这些化合物与至少一种另外的治疗有效药物的组合。
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公开(公告)号：US07767657B2
公开(公告)日：2010-08-03
申请号：US11505591
申请日：2006-08-16
申请人： Stephen J. Baker , Tsutomu Akama , Vincent S. Hernandez , Karin M. Hold , Kirk R. Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang , Gregory Fieldson
发明人： Stephen J. Baker , Tsutomu Akama , Vincent S. Hernandez , Karin M. Hold , Kirk R. Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang , Gregory Fieldson
IPC分类号： A61K31/69
CPC分类号： C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译： 本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物，并具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，毛发，爪或蹄特定部位的性质。 特别地，本发明化合物具有促进钉板穿透的物理化学性质。
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