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公开(公告)号:US20100130842A1
公开(公告)日:2010-05-27
申请号:US12597813
申请日:2008-04-28
申请人: Josef Hayoz , Rolf Wagner
发明人: Josef Hayoz , Rolf Wagner
IPC分类号: A61B5/1455
CPC分类号: A61B5/14542 , A61B5/026 , A61B5/14539 , A61B5/1477
摘要: The device for the transcutaneous determination of blood gases including a transcutaneous sensor for the measurement of at least one of the parameters of skin carbon dioxide partial pressure (PsCO2) and skin oxygen partial pressure (PsO2) includes at least one sensor for the measurement of the tissue blood flow (F) local with respect to the transcutaneous sensor, and includes a device for the calculation of at least one of the parameters of transcutaneous carbon dioxide partial pressure (tcpCO2) and transcutaneous oxygen partial pressure (tcpO2) from the measured skin carbon dioxide partial pressure (PsCO2) or the measured skin oxygen partial pressure (PsO2), with a factor dependent on the local tissue blood flow (F) being taken into account in the calculation of at least one of the parameters of transcutaneous carbon dioxide partial pressure (tcpCO2) and transcutaneous oxygen partial pressure (tcpO2).
摘要翻译: 包括用于测量皮肤二氧化碳分压(PsCO2)和皮肤氧分压(PsO2)中的至少一个参数的经皮传感器的用于经皮测定血液气体的装置包括至少一个用于测量 组织血流量(F)相对于经皮传感器是局部的,并且包括用于计算经皮二氧化碳分压(tcpCO2)和经皮氧分压(tcpO2)中的至少一个参数的装置, 在计算经皮二氧化碳分压的至少一个参数时,考虑到依赖于局部组织血流量(F)的因素的二氧化分压(PsCO2)或测量的皮肤氧分压(PsO2) (tcpCO2)和经皮氧分压(tcpO2)。
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公开(公告)号:US20100120753A1
公开(公告)日:2010-05-13
申请号:US12613607
申请日:2009-11-06
IPC分类号: A61K31/54 , C07D285/20 , A61P31/12
CPC分类号: C07D495/04
摘要: The present invention provides HCV polymerase inhibiting compounds having the formula (I): where R1 is cyclobutyl-N(Ra)—, n is 1, 2, 3 or 4, and at least one R5 is RaSO2N(Rj)alkyl-. In a non-limiting example, a compound of the present invention is N-[(3-{1-[(cyclobutyl)amino]-4-hydroxy-2-oxo-1,2-dihydro-quinolin-3-yl}-1,1-dioxo-1,4-dihydro-1λ6-thieno[2,3-e][1,2,4]thiadiazin-7-yl)methyl]methane-sulfonamide. The present invention also features compositions comprising the compounds of the present invention or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, and methods of using the same to treat or prevent HCV infection.
摘要翻译: 本发明提供了具有式(I)的HCV聚合酶抑制化合物:其中R1是环丁基-N(Ra) - ,n是1,2,3或4,并且至少一个R5是RaSO2N(Rj)烷基 - 。 在非限制性实例中,本发明的化合物是N - [(3- {1 - [(环丁基)氨基] -4-羟基-2-氧代-1,2-二氢 - 喹啉-3-基} -1,1-二氧代-1,4-二氢-1λ6-噻吩并[2,3-e] [1,2,4]噻二嗪-7-基)甲基]甲磺酰胺。 本发明还特征在于包含本发明化合物或其药学上可接受的盐,立体异构体或互变异构体的组合物及其用于治疗或预防HCV感染的方法。
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公开(公告)号:US20090186912A1
公开(公告)日:2009-07-23
申请号:US12212323
申请日:2008-09-17
申请人: Charles A. Flengte , Douglas K. Hutchinson , David A. Betebenner , David A. DeGoey , Pamela L. Donner , Warren M. Kati , Allan C. Krueger , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , Christopher E. Motter , John K. Pratt , John T. Randolph , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , Xiaochun Lou , Geoff G.Z. Zhang
发明人: Charles A. Flengte , Douglas K. Hutchinson , David A. Betebenner , David A. DeGoey , Pamela L. Donner , Warren M. Kati , Allan C. Krueger , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , Christopher E. Motter , John K. Pratt , John T. Randolph , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , Xiaochun Lou , Geoff G.Z. Zhang
IPC分类号: A61K31/513 , C07D239/10 , C07D401/10 , A61K31/506 , A61P31/12
CPC分类号: C07D239/54 , A61K31/513 , A61K45/06 , C07D239/22 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K2300/00
摘要: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
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公开(公告)号:US20090176784A1
公开(公告)日:2009-07-09
申请号:US12212315
申请日:2008-09-17
申请人: Pamela L. Donner , John T. Randolph , Allan C. Krueger , David A. Betebenner , Douglas K. Hutchinson , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , John K. Pratt , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , John E. Hengeveld , Rodger F. Henry , Xiaochun Lou , Geoff G.Z. Zhang
发明人: Pamela L. Donner , John T. Randolph , Allan C. Krueger , David A. Betebenner , Douglas K. Hutchinson , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , John K. Pratt , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , John E. Hengeveld , Rodger F. Henry , Xiaochun Lou , Geoff G.Z. Zhang
IPC分类号: A61K31/5377 , C07D239/22 , A61K31/513 , C07D401/10 , C07D413/10 , C12N7/06
CPC分类号: C07D239/22 , A61K31/513 , C07D239/54 , C07D239/553 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10
摘要: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
摘要翻译: 本发明涉及:(a)特别是抑制HCV的化合物及其盐; (b)可用于制备这些化合物和盐的中间体; (c)包含这些化合物和盐的组合物; (d)制备这种中间体,化合物,盐和组合物的方法; (e)使用这些化合物,盐和组合物的方法; 和(f)包含这些化合物,盐和组合物的试剂盒。
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公开(公告)号:US20080214528A1
公开(公告)日:2008-09-04
申请号:US11777692
申请日:2007-07-13
申请人: Rolf Wagner , Pamela L. Donner , Dale J. Kempf , Clarence J. Maring , Vincent S. Stoll , Yi-Yin Ku , Yu-Ming Pu
发明人: Rolf Wagner , Pamela L. Donner , Dale J. Kempf , Clarence J. Maring , Vincent S. Stoll , Yi-Yin Ku , Yu-Ming Pu
IPC分类号: A61K31/542 , C07D285/20 , A61P31/12
CPC分类号: C07D495/04
摘要: The present invention provides HCV polymerase inhibiting compounds having the formula (I): where R1 is cyclobutyl—N(Ra)-, n is 1, 2, 3 or 4, and at least one R5 is RaSO2N(Rj)alkyl-, In a non-limiting example, a compound of the present invention is N-[(3-{1-[(cyclobutyl)amino])-4-hydroxy -2-oxo-1,2-dihydro-quinolin-3-yl}-1,1-dioxo-1,4-dihydro-1λ6-thieno[2,3-e][1,2,4]thiadiazin-7-yl)methyl]methane-sulfonamide. The present invention also features compositions comprising the compounds of the present invention or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, and methods of using the same to treat or prevent HCV infection.
摘要翻译: 本发明提供了具有式(I)的HCV聚合酶抑制化合物:其中R 1是环丁基-N(R a)a,n是1,2,3或 4,并且至少一个R 5是R a,R 2,N(R j) - 烷基 - ,In 非限制性实例,本发明的化合物是N - [(3- {1 - [(环丁基)氨基])-4-羟基-2-氧代-1,2-二氢 - 喹啉-3-基} -1,1-二氧代-1,4-二氢-1-氮杂噻吩并[2,3-e] [1,2,4]噻二嗪-7-基)甲基]甲磺酰胺。 本发明还特征在于包含本发明化合物或其药学上可接受的盐,立体异构体或互变异构体的组合物及其用于治疗或预防HCV感染的方法。
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公开(公告)号:US20070232645A1
公开(公告)日:2007-10-04
申请号:US11613836
申请日:2006-12-20
申请人: Todd Rockway , David Betebenner , Allan Krueger , Nobuhiko Iwasaki , Curt Cooper , David Anderson , Dale Kempf , Darold Madigan , Christopher Motter , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu
发明人: Todd Rockway , David Betebenner , Allan Krueger , Nobuhiko Iwasaki , Curt Cooper , David Anderson , Dale Kempf , Darold Madigan , Christopher Motter , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu
IPC分类号: A61K31/4375 , C07D471/02 , C12N7/06
CPC分类号: C07D471/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号:US20070232627A1
公开(公告)日:2007-10-04
申请号:US11613810
申请日:2006-12-20
申请人: David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
发明人: David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
IPC分类号: A61K31/519 , A61K31/4375 , C07D239/70 , C07D471/02 , C12N7/06
CPC分类号: C07D471/04 , C07D495/04 , C07D513/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号:US20050234053A1
公开(公告)日:2005-10-20
申请号:US11051907
申请日:2005-02-04
申请人: Mira Hinman , Teresa Rosenberg , Rolf Wagner
发明人: Mira Hinman , Teresa Rosenberg , Rolf Wagner
IPC分类号: A61K31/4745 , A61K31/497 , A61K31/501 , A61K31/538 , C07D471/04 , C07D471/14 , C07D491/14 , C07D498/14
CPC分类号: C07D471/04
摘要: Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, salts of prodrugs, and metabolites thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
摘要翻译: 公开了具有式(I)的细菌蛋白质合成抑制化合物及其前体药物,前体药物及其代谢物的盐,该方法中的化合物和中间体的制备方法,含有该化合物的组合物,以及使用该化合物的方法。
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公开(公告)号:US06818654B2
公开(公告)日:2004-11-16
申请号:US10386816
申请日:2003-03-12
申请人: David Anderson , Bruce Beutel , Curt Cooper , Peter Dandliker , Caroline David , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Linda Lynch , Zhenkun Ma , Christopher Motter , Teresa Rosenberg , William Sanders , Michael Tufano , Rolf Wagner , Moshe Weitzberg , Hong Yong
发明人: David Anderson , Bruce Beutel , Curt Cooper , Peter Dandliker , Caroline David , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Linda Lynch , Zhenkun Ma , Christopher Motter , Teresa Rosenberg , William Sanders , Michael Tufano , Rolf Wagner , Moshe Weitzberg , Hong Yong
IPC分类号: C07D21500
CPC分类号: C07D471/04
摘要: Antibacterials having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.
摘要翻译: 公开了具有式(I)的抗菌剂及其前体药物的盐,前药和盐,用于制备本方法中使用的化合物和中间体的方法,含有该化合物的组合物,以及使用该化合物预防和治疗细菌感染的方法。
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公开(公告)号:US5128448A
公开(公告)日:1992-07-07
申请号:US463212
申请日:1990-01-10
申请人: Waleed Danho , David J. Nelson , Gary L. Olson , Shian-Jan Shiuey , Jefferson W. Tilley , Rolf Wagner
发明人: Waleed Danho , David J. Nelson , Gary L. Olson , Shian-Jan Shiuey , Jefferson W. Tilley , Rolf Wagner
IPC分类号: C07K14/595
CPC分类号: C07K14/595
摘要: The invention is directed to novel CCK analogs wherein Tryptophan and/or Phenylalamine are substituted with a radical which provides enhanced appetite suppressant activity to the peptide.
摘要翻译: 本发明涉及新的CCK类似物,其中色氨酸和/或苯基胺被提供对肽的增强的食欲抑制活性的基团取代。
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