公开(公告)号：US09173887B2

公开(公告)日：2015-11-03

申请号：US13995701

申请日：2011-12-16

Applicant: Clarence J. Maring ,  John K. Pratt ,  William A. Carroll ,  Dachun Liu ,  David A. Betebenner ,  Douglas K. Hutchinson ,  Michael D. Tufano ,  Todd W. Rockway ,  Uwe Schoen ,  Axel Pahl ,  Adreas Witte

Inventor： Clarence J. Maring ,  John K. Pratt ,  William A. Carroll ,  Dachun Liu ,  David A. Betebenner ,  Douglas K. Hutchinson ,  Michael D. Tufano ,  Todd W. Rockway ,  Uwe Schoen ,  Axel Pahl ,  Adreas Witte

IPC: C07D405/14 ,  C07D405/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/5395 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/437 ,  C07F7/18 ,  A61K31/4245 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61K45/06 ,  C07F9/6558

CPC classification number: C07F7/1804 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/5395 ,  A61K31/541 ,  A61K31/675 ,  A61K31/695 ,  A61K45/06 ,  B65D88/703 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F9/65586 ,  F16K31/363 ,  Y10T137/86405 ,  Y10T137/86421

Abstract: This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本公开涉及：（a）其特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：US08937150B2

公开(公告)日：2015-01-20

申请号：US13100827

申请日：2011-05-04

Applicant: David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Yi Gao ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  Michael D. Tufano ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi ,  William A. Carroll

Inventor： David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Yi Gao ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  Michael D. Tufano ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi ,  William A. Carroll

IPC: A61K31/66 ,  C07K16/00 ,  C07D401/14 ,  C07D491/113 ,  C07D413/14 ,  C07D403/14 ,  C07D417/14 ,  C07D405/14 ,  C07D453/00

CPC classification number: A61K31/454 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D491/113 ,  C07F7/02 ,  Y02P20/582

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US08415351B2

公开(公告)日：2013-04-09

申请号：US12725689

申请日：2010-03-17

Applicant: Rolf Wagner ,  Warren M. Kati ,  Dachun Liu ,  Yaya Liu ,  Kenton L. Longenecker ,  Clarence J. Maring ,  John K. Pratt ,  Todd W. Rockway ,  Kent D. Stewart ,  Michael D. Tufano

Inventor： Rolf Wagner ,  Warren M. Kati ,  Dachun Liu ,  Yaya Liu ,  Kenton L. Longenecker ,  Clarence J. Maring ,  John K. Pratt ,  Todd W. Rockway ,  Kent D. Stewart ,  Michael D. Tufano

IPC: C07D239/54 ,  C07D409/10 ,  A61K31/513

CPC classification number: A61K31/513 ,  A61K31/5377 ,  C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/14

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：US20120220562A1

公开(公告)日：2012-08-30

申请号：US13404429

申请日：2012-02-24

Applicant: David A DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Yi Gao ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  William A. Carroll

Inventor： David A DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Yi Gao ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  William A. Carroll

IPC: A61K31/496 ,  A61K31/506 ,  A61K31/4545 ,  A61P31/14 ,  C07D403/14 ,  C07D401/14 ,  C07D405/14 ,  A61K31/4178 ,  A61K31/454

CPC classification number: C07D403/14 ,  C07D207/16

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US20120082646A1

公开(公告)日：2012-04-05

申请号：US13260199

申请日：2010-03-25

Applicant: David A. Betebenner ,  John K. Pratt ,  David A. DeGoey ,  Pamela L. Donner ,  Charles A. Flentge ,  Douglas K. Hutchinson ,  Warren M. Kati ,  Allan C. Krueger ,  Kenton L. Longenecker ,  Clarence J. Maring ,  John T. Randolph ,  Todd W. Rockway ,  Michael D. Tufano ,  Rolf Wagner ,  Dachun Liu

Inventor： David A. Betebenner ,  John K. Pratt ,  David A. DeGoey ,  Pamela L. Donner ,  Charles A. Flentge ,  Douglas K. Hutchinson ,  Warren M. Kati ,  Allan C. Krueger ,  Kenton L. Longenecker ,  Clarence J. Maring ,  John T. Randolph ,  Todd W. Rockway ,  Michael D. Tufano ,  Rolf Wagner ,  Dachun Liu

IPC: A61K31/513 ,  C07D409/08 ,  C07D213/64 ,  C07C311/08 ,  C07D233/72 ,  A61P31/14 ,  A61K31/18 ,  A61K31/4166 ,  A61K31/27 ,  C12N9/99 ,  A61K38/21 ,  A61K31/7056 ,  C07D239/54 ,  A61K31/4418

CPC classification number: C07D409/10 ,  A61K31/18 ,  A61K31/27 ,  A61K31/402 ,  A61K31/4166 ,  A61K31/421 ,  A61K31/425 ,  A61K31/4418 ,  A61K31/503 ,  A61K31/513 ,  A61K45/06 ,  C07C311/08 ,  C07D207/27 ,  C07D213/64 ,  C07D233/32 ,  C07D233/72 ,  C07D239/10 ,  C07D239/54 ,  C07D263/22 ,  C07D263/24 ,  C07D275/02 ,  C07D403/10 ,  C07D405/10 ,  Y02P20/55

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：US06376488B1

公开(公告)日：2002-04-23

申请号：US09657296

申请日：2000-09-07

Applicant: Fatima Z. Basha ,  Michael D. Wendt ,  John K. Pratt

Inventor： Fatima Z. Basha ,  Michael D. Wendt ,  John K. Pratt

IPC: A61K315365

CPC classification number: C07D519/00

Abstract: The present invention relates to compounds having formula I and to pharmaceutically acceptable salts thereof. Compounds of formula I inhibit &agr;1 adrenoreceptors and may be useful for treating benign prostatic hyperplasia (also called benign prostatic hypertrophy) and other urological diseases such as bladder outlet obstruction, neurogenic bladder and gynecological syndromes.

Abstract translation: 本发明涉及具有式I的化合物及其药学上可接受的盐。 式I的化合物抑制α1肾上腺素受体，并且可用于治疗良性前列腺增生（也称为良性前列腺肥大）和其它泌尿系统疾病，例如膀胱出口阻塞，神经源性膀胱和妇科综合征。

公开(公告)号：US5045554A

公开(公告)日：1991-09-03

申请号：US414667

申请日：1989-10-03

Applicant: Gerhard H. Alt ,  W. Gary Phillips ,  John K. Pratt ,  Gabriel H. Srouji

Inventor： Gerhard H. Alt ,  W. Gary Phillips ,  John K. Pratt ,  Gabriel H. Srouji

IPC: C07D277/20 ,  A01N43/78 ,  A01P3/00 ,  A61L20060101 ,  C07D277/24 ,  C07D277/30 ,  C07D277/56

CPC classification number: C07D277/56 ,  A01N43/78

Abstract: The present invention relates to certain substituted 5-carboxanilidothiazoles and their use as fungicides.

公开(公告)号：US08921514B2

公开(公告)日：2014-12-30

申请号：US12964027

申请日：2010-12-09

Applicant: David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Yi Gao ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  Michael D. Tufano ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi ,  William A. Carroll

Inventor： David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Yi Gao ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  Michael D. Tufano ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi ,  William A. Carroll

IPC: A61K31/66 ,  C07K16/00 ,  C07D453/00 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D491/113

CPC classification number: C07F9/65583 ,  C07C33/26 ,  C07C201/06 ,  C07C205/19 ,  C07D207/08 ,  C07D207/09 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D471/04 ,  C07D491/113 ,  C07K5/06

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US08741914B2

公开(公告)日：2014-06-03

申请号：US13260206

申请日：2010-03-25

Applicant: Todd W. Rockway ,  David A. Betebenner ,  David A. DeGoey ,  Charles A. Flentge ,  Douglas K. Hutchinson ,  Warren M. Kati ,  Allan C. Krueger ,  Dachun Liu ,  Kenton L. Longenecker ,  John K. Pratt ,  Kent D. Stewart ,  Rolf Wagner ,  Clarence J. Maring

Inventor： Todd W. Rockway ,  David A. Betebenner ,  David A. DeGoey ,  Charles A. Flentge ,  Douglas K. Hutchinson ,  Warren M. Kati ,  Allan C. Krueger ,  Dachun Liu ,  Kenton L. Longenecker ,  John K. Pratt ,  Kent D. Stewart ,  Rolf Wagner ,  Clarence J. Maring

IPC: C07D401/04 ,  C07D403/04 ,  A61K31/513

CPC classification number: C07D401/04 ,  C07D403/04 ,  C07D407/04 ,  C07D409/14

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：US08497275B2

公开(公告)日：2013-07-30

申请号：US12492518

申请日：2009-06-26

Applicant: Brian E. Green ,  David D. Anderson ,  Todd D. Bosse ,  Curt S. Cooper ,  Larry L. Klein ,  Allan C. Krueger ,  Daniel P. Larson ,  Dachun Liu ,  Keith F. McDaniel ,  Christopher E. Motter ,  John K. Pratt ,  Todd W. Rockway ,  Teresa A. Rosenberg ,  Ming C. Yeung ,  Hui-Ju Chen ,  Jason P. Shanley

Inventor： Brian E. Green ,  David D. Anderson ,  Todd D. Bosse ,  Curt S. Cooper ,  Larry L. Klein ,  Allan C. Krueger ,  Daniel P. Larson ,  Dachun Liu ,  Keith F. McDaniel ,  Christopher E. Motter ,  John K. Pratt ,  Todd W. Rockway ,  Teresa A. Rosenberg ,  Ming C. Yeung ,  Hui-Ju Chen ,  Jason P. Shanley

IPC: A61K31/4965 ,  A61K31/40 ,  A61K38/00 ,  A61K38/05

CPC classification number: C07D403/12 ,  C07D207/16 ,  C07D241/24 ,  C07D403/14 ,  C07D409/14 ,  C07K7/02

Abstract: This invention relates to: (a) compounds of formula I and salts thereof that, inter alia, are useful as hepatitis C virus (HCV) inhibitors; (b) intermediates useful for the preparation of such compounds and salts; (c) pharmaceutical compositions comprising such compounds and salts; and (d) methods of use of such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）式I化合物及其盐，其特别可用作丙型肝炎病毒（HCV）抑制剂; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的药物组合物; 和（d）使用这些化合物，盐和组合物的方法。