公开(公告)号：US08748443B2

公开(公告)日：2014-06-10

申请号：US13260199

申请日：2010-03-25

Applicant: David A. Betebenner ,  John K. Pratt ,  David A. DeGoey ,  Pamela L. Donner ,  Charles A. Flentge ,  Douglas K. Hutchinson ,  Warren M. Kati ,  Allan C. Krueger ,  Kenton L. Longenecker ,  Clarence J. Maring ,  John T. Randolph ,  Todd W. Rockway ,  Michael D. Tufano ,  Rolf Wagner ,  Dachun Liu

Inventor： David A. Betebenner ,  John K. Pratt ,  David A. DeGoey ,  Pamela L. Donner ,  Charles A. Flentge ,  Douglas K. Hutchinson ,  Warren M. Kati ,  Allan C. Krueger ,  Kenton L. Longenecker ,  Clarence J. Maring ,  John T. Randolph ,  Todd W. Rockway ,  Michael D. Tufano ,  Rolf Wagner ,  Dachun Liu

IPC: A01N43/54 ,  A61K31/505 ,  A61K31/503 ,  C07D239/54

CPC classification number: C07D409/10 ,  A61K31/18 ,  A61K31/27 ,  A61K31/402 ,  A61K31/4166 ,  A61K31/421 ,  A61K31/425 ,  A61K31/4418 ,  A61K31/503 ,  A61K31/513 ,  A61K45/06 ,  C07C311/08 ,  C07D207/27 ,  C07D213/64 ,  C07D233/32 ,  C07D233/72 ,  C07D239/10 ,  C07D239/54 ,  C07D263/22 ,  C07D263/24 ,  C07D275/02 ,  C07D403/10 ,  C07D405/10 ,  Y02P20/55

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：US08691938B2

公开(公告)日：2014-04-08

申请号：US12813301

申请日：2010-06-10

Applicant: David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Yi Gao ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  Michael D. Tufano ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi

Inventor： David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Yi Gao ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  Michael D. Tufano ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi

IPC: C07K16/00 ,  A61K31/66

CPC classification number: C07F9/65583 ,  C07C33/26 ,  C07C201/06 ,  C07C205/19 ,  C07D207/08 ,  C07D207/09 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D471/04 ,  C07D491/113 ,  C07K5/06

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Abstract translation: 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：US20120004196A1

公开(公告)日：2012-01-05

申请号：US13100827

申请日：2011-05-04

Applicant: David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Yi Gao ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  Michael D. Tufano ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi ,  William A. Carroll

Inventor： David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Yi Gao ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  Michael D. Tufano ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi ,  William A. Carroll

IPC: A61K31/4184 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07F7/10 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/422 ,  A61K31/438 ,  A61K31/4545 ,  A61K31/695 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61P31/14 ,  C07D403/14

CPC classification number: A61K31/454 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D491/113 ,  C07F7/02 ,  Y02P20/582

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Abstract translation: 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：US07915411B2

公开(公告)日：2011-03-29

申请号：US11613825

申请日：2006-12-20

Applicant: David A. Betebenner ,  David A. DeGoey ,  Clarence J. Maring ,  Allan C. Krueger ,  Nobuhiko Iwasaki ,  Todd W. Rockway ,  Curt S. Cooper ,  David D. Anderson ,  Pamela L. Donner ,  Brian E. Green ,  Dale J. Kempf ,  Dachun Liu ,  Keith F. McDaniel ,  Darold L. Madigan ,  Christopher E. Motter ,  John K. Pratt ,  Jason P. Shanley ,  Michael D. Tufano ,  Rolf Wagner ,  Rong Zhang ,  Akhteruzzaman Molla ,  Hongmei Mo ,  Tami J. Pilot-Matias ,  Sherie V L. Masse ,  Robert J. Carrick ,  Wenping He ,  Liangjun Lu ,  David J. Grampovnik

Inventor： David A. Betebenner ,  David A. DeGoey ,  Clarence J. Maring ,  Allan C. Krueger ,  Nobuhiko Iwasaki ,  Todd W. Rockway ,  Curt S. Cooper ,  David D. Anderson ,  Pamela L. Donner ,  Brian E. Green ,  Dale J. Kempf ,  Dachun Liu ,  Keith F. McDaniel ,  Darold L. Madigan ,  Christopher E. Motter ,  John K. Pratt ,  Jason P. Shanley ,  Michael D. Tufano ,  Rolf Wagner ,  Rong Zhang ,  Akhteruzzaman Molla ,  Hongmei Mo ,  Tami J. Pilot-Matias ,  Sherie V L. Masse ,  Robert J. Carrick ,  Wenping He ,  Liangjun Lu ,  David J. Grampovnik

IPC: C07D471/04 ,  A61P1/16

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D475/06 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：US20110003827A1

公开(公告)日：2011-01-06

申请号：US11009841

申请日：2004-12-10

Applicant: Charles A. Flentge ,  Hui-Ju Chen ,  David A. DeGoey ,  William J. Flosi ,  David J. Grampovnik ,  Peggy P. Huang ,  Dale J. Kempf ,  Larry L. Klein ,  Allan C. Krueger ,  Darold L. Madigan ,  John T. Randolph ,  Minghua Sun ,  Ming C. Yeung ,  Chen Zhao

Inventor： Charles A. Flentge ,  Hui-Ju Chen ,  David A. DeGoey ,  William J. Flosi ,  David J. Grampovnik ,  Peggy P. Huang ,  Dale J. Kempf ,  Larry L. Klein ,  Allan C. Krueger ,  Darold L. Madigan ,  John T. Randolph ,  Minghua Sun ,  Ming C. Yeung ,  Chen Zhao

IPC: A61K31/501 ,  C07C317/48 ,  C07C311/37 ,  C07D213/46 ,  C07D307/14 ,  C07D333/22 ,  C07D417/12 ,  C07D409/06 ,  C07D403/06 ,  C07D471/04 ,  A61K31/216 ,  A61K31/18 ,  A61K31/4402 ,  A61K31/341 ,  A61K31/381 ,  A61K31/427 ,  A61K31/4178 ,  A61K31/4709 ,  A61K31/437 ,  A61K31/506 ,  A61P31/18

CPC classification number: C07D417/12 ,  C07C311/18 ,  C07C311/29 ,  C07C311/41 ,  C07C311/47 ,  C07C317/18 ,  C07D209/14 ,  C07D213/30 ,  C07D213/40 ,  C07D233/36 ,  C07D233/64 ,  C07D233/72 ,  C07D277/24 ,  C07D277/28 ,  C07D307/14 ,  C07D307/20 ,  C07D307/52 ,  C07D333/20 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/10 ,  C07D409/06 ,  C07D409/10 ,  C07D417/06 ,  C07D417/10 ,  C07D471/04 ,  C07D493/04

Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

Abstract translation: 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。

公开(公告)号：US08501238B2

公开(公告)日：2013-08-06

申请号：US13451889

申请日：2012-04-20

Applicant: Charles A. Flentge ,  Douglas K. Hutchinson ,  David A. Betebenner ,  David A. DeGoey ,  Pamela L. Donner ,  Warren M. Kati ,  Allan C. Krueger ,  Dachun Liu ,  Yaya Liu ,  Kenton L. Longenecker ,  Clarence J. Maring ,  Christopher E. Motter ,  John K. Pratt ,  John T. Randolph ,  Todd W. Rockway ,  Kent D. Stewart ,  Rolf Wagner ,  Shuang Chen ,  Yi Gao ,  Xiaochun Lou ,  Geoff G. Z. Zhang

Inventor： Charles A. Flentge ,  Douglas K. Hutchinson ,  David A. Betebenner ,  David A. DeGoey ,  Pamela L. Donner ,  Warren M. Kati ,  Allan C. Krueger ,  Dachun Liu ,  Yaya Liu ,  Kenton L. Longenecker ,  Clarence J. Maring ,  Christopher E. Motter ,  John K. Pratt ,  John T. Randolph ,  Todd W. Rockway ,  Kent D. Stewart ,  Rolf Wagner ,  Shuang Chen ,  Yi Gao ,  Xiaochun Lou ,  Geoff G. Z. Zhang

IPC: A61K9/14 ,  A61K31/505 ,  C07D239/02 ,  C07D401/00

CPC classification number: C07D239/54 ,  A61K31/513 ,  A61K45/06 ,  C07D239/22 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K2300/00

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：US20120244119A1

公开(公告)日：2012-09-27

申请号：US13451889

申请日：2012-04-20

Applicant: Charles A. Flentge ,  Douglas K. Hutchinson ,  David A. Betebenner ,  David A. DeGoey ,  Pamela L. Donner ,  Warren M. Kati ,  Allan C. Krueger ,  Dachun Liu ,  Yaya Liu ,  Kenton L. Longenecker ,  Clarence J. Maring ,  Christopher E. Motter ,  John K. Pratt ,  John T. Randolph ,  Todd W. Rockway ,  Kent D. Stewart ,  Rolf Wagner ,  Shuang Chen ,  Yi Gao ,  Xiaochun Lou ,  Geoff G.Z. Zhang

Inventor： Charles A. Flentge ,  Douglas K. Hutchinson ,  David A. Betebenner ,  David A. DeGoey ,  Pamela L. Donner ,  Warren M. Kati ,  Allan C. Krueger ,  Dachun Liu ,  Yaya Liu ,  Kenton L. Longenecker ,  Clarence J. Maring ,  Christopher E. Motter ,  John K. Pratt ,  John T. Randolph ,  Todd W. Rockway ,  Kent D. Stewart ,  Rolf Wagner ,  Shuang Chen ,  Yi Gao ,  Xiaochun Lou ,  Geoff G.Z. Zhang

IPC: C07D239/54 ,  A61K38/21 ,  A61P31/14 ,  A61K31/513

CPC classification number: C07D239/54 ,  A61K31/513 ,  A61K45/06 ,  C07D239/22 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K2300/00

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：US07910595B2

公开(公告)日：2011-03-22

申请号：US11613810

申请日：2006-12-20

Applicant: David A. Betebenner ,  David A. DeGoey ,  Clarence J. Maring ,  Allan C. Krueger ,  Nobuhiko Iwasaki ,  Todd W. Rockway ,  Curt S. Cooper ,  David D. Anderson ,  Pamela L. Donner ,  Brian E. Green ,  Dale J. Kempf ,  Dachun Liu ,  Keith F. McDaniel ,  Darold L. Madigan ,  Christopher E. Motter ,  John K. Pratt ,  Jason P. Shanley ,  Michael D. Tufano ,  Rolf Wagner ,  Rong Zhang ,  Akhteruzzaman Molla ,  Hongmei Mo ,  Tami J. Pilot-Matias ,  Sherie V L. Masse ,  Robert J. Carrick ,  Wenping He ,  Liangjun Lu ,  David J. Grampovnik

Inventor： David A. Betebenner ,  David A. DeGoey ,  Clarence J. Maring ,  Allan C. Krueger ,  Nobuhiko Iwasaki ,  Todd W. Rockway ,  Curt S. Cooper ,  David D. Anderson ,  Pamela L. Donner ,  Brian E. Green ,  Dale J. Kempf ,  Dachun Liu ,  Keith F. McDaniel ,  Darold L. Madigan ,  Christopher E. Motter ,  John K. Pratt ,  Jason P. Shanley ,  Michael D. Tufano ,  Rolf Wagner ,  Rong Zhang ,  Akhteruzzaman Molla ,  Hongmei Mo ,  Tami J. Pilot-Matias ,  Sherie V L. Masse ,  Robert J. Carrick ,  Wenping He ,  Liangjun Lu ,  David J. Grampovnik

IPC: C07D471/04 ,  A01N31/519 ,  A61P31/12

CPC classification number: C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Abstract translation: 公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。

公开(公告)号：US20100317568A1

公开(公告)日：2010-12-16

申请号：US12813301

申请日：2010-06-10

Applicant: David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Todd N. Soltwedel ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  Michael D. Tufano ,  David A. Betebenner ,  Michael J. Lavin ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi

Inventor： David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Todd N. Soltwedel ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  Michael D. Tufano ,  David A. Betebenner ,  Michael J. Lavin ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi

IPC: A61K38/05 ,  C07D403/14 ,  A61P31/14 ,  C07D401/14 ,  A61K31/4178 ,  A61K31/4184 ,  C07D413/14 ,  C07D417/14 ,  A61K31/428 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  C07F9/6506 ,  A61K31/675 ,  C07D491/113 ,  A61K31/438 ,  C07D279/12 ,  A61K31/541

CPC classification number: C07F9/65583 ,  C07C33/26 ,  C07C201/06 ,  C07C205/19 ,  C07D207/08 ,  C07D207/09 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D471/04 ,  C07D491/113 ,  C07K5/06

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US20100168138A1

公开(公告)日：2010-07-01

申请号：US12644427

申请日：2009-12-22

Applicant: David A. DeGoey ,  Pamela L. Donner ,  Warren M. Kati ,  Charles W. Hutchins ,  Mark A. Matulenko ,  Tammie K. Jinkerson ,  Ryan G. Keddy

Inventor： David A. DeGoey ,  Pamela L. Donner ,  Warren M. Kati ,  Charles W. Hutchins ,  Mark A. Matulenko ,  Tammie K. Jinkerson ,  Ryan G. Keddy

IPC: A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  A61P31/12

CPC classification number: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.