公开(公告)号：US20050159591A1

公开(公告)日：2005-07-21

申请号：US11021329

申请日：2004-12-21

申请人： Wei-Qiang Gao ,  Audrey Goddard ,  Austin Gurney ,  Colin Watanabe ,  William Wood

发明人： Wei-Qiang Gao ,  Audrey Goddard ,  Austin Gurney ,  Colin Watanabe ,  William Wood

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K14/705 ,  C07K16/30 ,  C12N1/18 ,  C12N5/06 ,  C12Q1/68

CPC分类号： A61K39/395 ,  C07H21/04 ,  C07K14/705 ,  C07K16/30 ,  C12N1/18 ,  C12N5/06 ,  C12Q1/68

摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US06653279B1

公开(公告)日：2003-11-25

申请号：US09644368

申请日：2000-08-23

申请人： Wei-Qiang Gao

发明人： Wei-Qiang Gao

IPC分类号： A61K3800

CPC分类号： A61K38/1825 ,  A61K38/1841 ,  A61K38/30 ,  Y10S435/81 ,  A61K2300/00

摘要： Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.

摘要翻译： 提供了组合物，方法和装置，用于诱导或增强内耳组织，特别是内耳毛细胞的生长，增殖，再生。 此外，提供了通过施用治疗有效量的IGF-1来预防或治疗患有内耳障碍或病症的哺乳动物，特别是涉及毛细胞损伤，损失或变性的听力损伤的组合物和方法 或FGF-2，或其激动剂，单独或组合使用。

公开(公告)号：US06429191B1

公开(公告)日：2002-08-06

申请号：US09823717

申请日：2001-03-30

申请人： Wei-Qiang Gao

发明人： Wei-Qiang Gao

IPC分类号： A61K3800

CPC分类号： C12N5/062 ,  A61K38/185 ,  C12N2501/13 ,  C12N2503/02

摘要： Compositions and methods are provided for prophylactic or therapeutic treatment of a mammal for hearing impairments involving neuronal damage, loss, or degeneration, preferably of spinal ganglion neurons, by administration of a therapeutically effective amount of a trkB or trkC agonist, particularly a neurotrophin, more preferably NT-4/5. Also provided are improved compositions and methods for treatments requiring administration of a pharmaceutical having an ototoxic side-effect, wherein the improvement includes administering a therapeutically effective amount of a trkB or trkC agonist to treat the ototoxicity.

摘要翻译： 提供组合物和方法，用于通过施用治疗有效量的trkB或trkC激动剂，特别是神经营养因子来预防或治疗哺乳动物用于涉及神经元损伤，损失或退化，优选脊髓神经节神经元的听力损伤 优选NT-4/5。 还提供了需要施用具有耳毒性副作用的药物的治疗的改进的组合物和方法，其中改进包括施用治疗有效量的trkB或trkC激动剂以治疗耳毒性。

公开(公告)号：US6156728A

公开(公告)日：2000-12-05

申请号：US963596

申请日：1997-10-31

申请人： Wei-Qiang Gao

发明人： Wei-Qiang Gao

IPC分类号： A61K38/18 ,  A61K38/30 ,  A61K38/00 ,  A61K38/16

CPC分类号： A61K38/1825 ,  A61K38/1841 ,  A61K38/30 ,  Y10S435/81

摘要： Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.

公开(公告)号：US20090142259A1

公开(公告)日：2009-06-04

申请号：US11746497

申请日：2007-05-09

申请人： Wei-Qiang Gao ,  Bu-er Wang

发明人： Wei-Qiang Gao ,  Bu-er Wang

IPC分类号： A61K51/00 ,  C12Q1/68 ,  C12N5/08 ,  A61K31/7088 ,  A61P35/00 ,  G01N33/53 ,  A61K38/02 ,  A61K38/43

CPC分类号： G01N33/57407

摘要： The present invention is directed to methods of diagnosing and treating, as well as articles of manufacture useful for diagnosing and treating, bladder and/or urinary tract tumor in mammals.

摘要翻译： 本发明涉及用于诊断和治疗哺乳动物膀胱和/或泌尿道肿瘤的诊断和治疗方法以及制造物。

公开(公告)号：US06593290B1

公开(公告)日：2003-07-15

申请号：US08743267

申请日：1996-11-04

申请人： Wei-Qiang Gao

发明人： Wei-Qiang Gao

IPC分类号： A61K3800

CPC分类号： A61K38/30 ,  A61K38/1825 ,  A61K38/1841 ,  A61K2300/00

摘要： Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration, or survival of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.

摘要翻译： 提供组合物，方法和装置用于诱导或增强内耳组织，特别是内耳毛细胞的生长，增殖，再生或存活。 此外，提供了通过施用治疗有效量的IGF-1来预防或治疗患有内耳障碍或病症的哺乳动物，特别是涉及毛细胞损伤，损失或变性的听力损伤的组合物和方法 或FGF-2，或其激动剂，单独或组合使用。

公开(公告)号：US20110262465A1

公开(公告)日：2011-10-27

申请号：US13124428

申请日：2009-10-21

申请人： Wei-Qiang Gao ,  Leisa Johnson ,  Kevin G. Leong

发明人： Wei-Qiang Gao ,  Leisa Johnson ,  Kevin G. Leong

IPC分类号： A61K39/395 ,  C12N5/02 ,  A61P35/00 ,  A61K31/404 ,  C12Q1/02 ,  C12N5/00 ,  A61K31/497

CPC分类号： C12N5/0683

摘要： Prostate stem cells and prostate cancer stem cells and their use in treating prostate cancer and regenerating prostate tissue are disclosed.

摘要翻译： 公开了前列腺干细胞和前列腺癌干细胞及其在治疗前列腺癌和再生前列腺组织中的用途。

公开(公告)号：US06927204B2

公开(公告)日：2005-08-09

申请号：US10458039

申请日：2003-06-09

申请人： Wei-Qiang Gao

发明人： Wei-Qiang Gao

IPC分类号： A61K38/18 ,  A61K38/30 ,  A61K38/00 ,  A61K38/28 ,  A61K39/395 ,  C07K16/00

CPC分类号： A61K38/1825 ,  A61K38/1841 ,  A61K38/30 ,  Y10S435/81 ,  A61K2300/00

摘要： Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.

摘要翻译： 提供了组合物，方法和装置，用于诱导或增强内耳组织，特别是内耳毛细胞的生长，增殖，再生。 此外，提供了通过施用治疗有效量的IGF-1来预防或治疗患有内耳障碍或病症的哺乳动物，特别是涉及毛细胞损伤，损失或变性的听力损伤的组合物和方法 或FGF-2，或其激动剂，单独或组合使用。

公开(公告)号：US06225282B1

公开(公告)日：2001-05-01

申请号：US08778357

申请日：1997-01-02

申请人： Wei-Qiang Gao

发明人： Wei-Qiang Gao

IPC分类号： A61K3800

CPC分类号： C12N5/062 ,  A61K38/185 ,  C12N2501/13 ,  C12N2503/02

摘要： Compositions and methods are provided for prophylactic or therapeutic treatment of a mammal for hearing impairments involving neuronal damage, loss, or degeneration, preferably of spinal ganglion neurons, by administration of a therapeutically effective amount of a trkB or trkC agonist, particularly a neurotrophin, more preferably NT-4/5. Also provided are improved compositions and methods for treatments requiring administration of a pharmaceutical having an ototoxic side-effect, wherein the improvement includes administering a therapeutically effective amount of a trkB or trkC agonist to treat the ototoxicity.

摘要翻译： 提供组合物和方法，用于通过施用治疗有效量的trkB或trkC激动剂，特别是神经营养因子来预防或治疗哺乳动物用于涉及神经元损伤，损失或退化，优选脊髓神经节神经元的听力损伤 优选NT-4/5。 还提供了需要施用具有耳毒性副作用的药物的治疗的改进的组合物和方法，其中改进包括施用治疗有效量的trkB或trkC激动剂以治疗耳毒性。

公开(公告)号：US06974798B2

公开(公告)日：2005-12-13

申请号：US10096762

申请日：2002-03-12

申请人： Wei-Qiang Gao

发明人： Wei-Qiang Gao

IPC分类号： A61K38/18 ,  A61K31/70 ,  A61K33/24 ,  A61K38/00 ,  G01N33/00 ,  G01N33/48

CPC分类号： A61K38/185 ,  Y02A50/473 ,  A61K2300/00

摘要： Compositions and methods are provided for prophylactic or therapeutic treatment of balance impairments involving neuronal damage, loss, or degeneration, preferably of vestibular ganglion neurons, in an animal by administration of an effective amount of a trkB or trkC agonist, particularly a neurotrophin, more preferably NT-4/5.

摘要翻译： 提供了组合物和方法，用于通过施用有效量的trkB或trkC激动剂，特别是神经营养因子，更优选地在动物中预防或治疗涉及神经元损伤，损失或变性（优选前庭神经节神经元）的平衡障碍 NT-4/5。