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    Stent delivery system
    71.
    发明授权
    Stent delivery system 失效

    公开(公告)号：US5782855A

    公开(公告)日：1998-07-21

    申请号：US630528

    申请日：1996-04-10

    申请人： Lilip Lau ,  William M. Hartigan ,  Farhad Khosravi ,  Kurt R. Klemm ,  Ulrich Sigwart

    发明人： Lilip Lau ,  William M. Hartigan ,  Farhad Khosravi ,  Kurt R. Klemm ,  Ulrich Sigwart

    IPC分类号： A61F2/82 ,  A61F2/06 ,  A61F2/84 ,  A61M25/00 ,  A61M25/01 ,  A61M29/00

    CPC分类号： A61F2/97 ,  A61F2/958 ,  A61F2002/9517 ,  A61M2025/0183 ,  A61M2025/1081

    摘要： The invention is directed to a stent delivery method and system which generally includes an elongated delivery sheath and a catheter disposed within an outer lumen of the sheath having an expandable member on its distal extremity. An expandable stent is mounted on the expandable member of the catheter. The distal portion of the sheath tapers down and is tucked within an elastic cone during transport of the stent to a stenotic region. A manipulating device is provided on the proximal end of the delivery system to effect relative axial movement between the sheath and the catheter so as to expose the stent mounted on the expandable member on the catheter within a body lumen such as a coronary artery and allow the expansion of the stent by the expansion of the expandable member. The elastic cone thereby disengages from the sheath and collapses about the distal end of the catheter. The delivery sheath has a first port in its distal end and a second port in the sheath wall proximally disposed from the distal end of the sheath. The catheter likewise has a first port in its distal end and a second port proximally disposed from the distal end of the catheter. An inner lumen extends within the distal portion of the catheter between the first and second ports and slidably receives a guiding member such as a guidewire. This system allows the stent to be delivered over a guidewire previously advanced to the desired location within a body lumen.

    Ratcheting stent
    73.
    发明授权
    Ratcheting stent 失效
    棘轮支架

    公开(公告)号：US5618299A

    公开(公告)日：1997-04-08

    申请号：US512300

    申请日：1995-08-08

    申请人： Farhad Khosravi ,  Michael S. Williams

    发明人： Farhad Khosravi ,  Michael S. Williams

    IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/92 ,  A61M29/00

    CPC分类号： A61F2/93 ,  A61F2/07 ,  A61F2/958 ,  A61F2210/0004 ,  A61F2250/0067

    摘要： An intravascular stent including a cylindrical sheet having overlapping edges that interlock. The edges have a series of protrusions and apertures that interlock and ratchet as the stent expands to an open position to support a section of arterial wall. The stent may be expanded by a balloon catheter or it may be self-expanding. The stent is biocompatible, may be bio-erodible, and capable of localized drug delivery. A plurality of retaining members to keep the stent open are disclosed. In one embodiment a buckle fastening member is used, while in another embodiment a helical seam containing projections is employed. The stent may be wound in such a manner that during expansion of the stent one side of the sheet desires to return to its original shape, creating a bias. In addition, a variety of reticulated structure stents are disclosed, with novel geometric patterns that aid in increased flexibility while preserving radial strength and also allow blood-tissue interaction and side branch access. The intravascular stent may be made of a sheet of material strengthened and stiffened by pyrolytic carbon or by structural reinforcement as in composite laminates.

    摘要翻译： 包括具有互锁的重叠边缘的圆柱形片的血管内支架。 边缘具有一系列突起和孔，当支架膨胀到打开位置以支撑动脉壁的一部分时，其互锁并棘轮。 支架可以通过气囊导管扩张，或者可以是自扩张的。 支架是生物相容的，可以是生物可蚀刻的，并且能够局部药物递送。 公开了保持支架打开的多个保持构件。 在一个实施例中，使用带扣紧固构件，而在另一实施例中采用了包含凸起的螺旋缝。 支架可以以这样的方式被卷绕，即在支架的膨胀期间，片材的一侧期望返回到其原始形状，产生偏压。 此外，公开了各种网状结构支架，其具有新颖的几何图案，其有助于增加柔性，同时保持径向强度并且还允许血液 - 组织相互作用和侧分支进入。 血管内支架可以由通过热解碳强化和加固的材料制成，或者通过结构加强制成，如在复合层压板中。

    Ratcheting stent
    74.
    发明授权
    Ratcheting stent 失效
    棘轮支架

    公开(公告)号：US5441515A

    公开(公告)日：1995-08-15

    申请号：US52410

    申请日：1993-04-23

    申请人： Farhad Khosravi ,  Michael S. Williams

    发明人： Farhad Khosravi ,  Michael S. Williams

    IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/92 ,  A61M29/00 ,  A61F2/06

    CPC分类号： A61F2/93 ,  A61F2/07 ,  A61F2/958 ,  A61F2210/0004 ,  A61F2250/0067

    摘要： An intravascular stent comprising a cylindrical sheet having overlapplng edges that interlock. The edges have a series of protrusions and apertures that interlock and ratchet as the stent expands to an open position to support a section of arterial wall. The stent may be expanded by a balloon catheter or it may be self-expanding. The stent is biocompatible, may be bio-erodible, and capable of localized drug delivery.A plurality of retaining members to keep the stent open are disclosed. In one embodiment a buckle fastening member is used, while in another embodiment a helical seam containing projections is employed. The stent may be wound in such a manner that during expansion of the stent one side of the sheet comprising the stent desires to return to its original shape, creating a bias. In addition, a variety of reticulated structure stents are disclosed, with novel geometric patterns that aid in increased flexibility while preserving radial strength and also allow blood-tissue interaction and side branch access.The intravascular stent may be made of a sheet of material strengthened and stiffened by pyrolytic carbon or by structural reinforcement as in composite laminates.

    摘要翻译： 一种血管内支架，其包括具有互锁的重叠边缘的圆柱形片。 边缘具有一系列突起和孔，当支架膨胀到打开位置以支撑动脉壁的一部分时，其互锁并棘轮。 支架可以通过气囊导管扩张，或者可以是自扩张的。 支架是生物相容的，可以是生物可蚀刻的，并且能够局部药物递送。 公开了保持支架打开的多个保持构件。 在一个实施例中，使用带扣紧固构件，而在另一实施例中采用了包含凸起的螺旋缝。 支架可以以这样的方式被卷绕，即在支架膨胀期间，包括支架的片的一侧期望返回其原始形状，产生偏压。 此外，公开了各种网状结构支架，其具有新颖的几何图案，其有助于增加柔性，同时保持径向强度并且还允许血液 - 组织相互作用和侧分支进入。 血管内支架可以由通过热解碳强化和加固的材料制成，或者通过结构加强制成，如在复合层压板中。

    Auto-retraction apparatus and methods for sealing a vascular puncture
    76.
    发明授权
    Auto-retraction apparatus and methods for sealing a vascular puncture 有权
    自动回缩装置和密封血管穿刺的方法

    公开(公告)号：US09289195B2

    公开(公告)日：2016-03-22

    申请号：US10806952

    申请日：2004-03-22

    申请人： Celso J. Bagaoisan ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    发明人： Celso J. Bagaoisan ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    IPC分类号： A61B17/08 ,  A61B17/00 ,  A61M25/10 ,  A61M25/06

    CPC分类号： A61B17/0057 ,  A61B2017/00495 ,  A61B2017/00557 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00986 ,  A61M25/1002 ,  A61M25/10182 ,  A61M25/10184 ,  A61M25/10187 ,  A61M2025/0681

    摘要： Apparatus for sealing a puncture communicating with a blood vessel includes an introducer sheath, an occlusion member with a balloon thereon, a retraction assembly, and a syringe assembly including sealing material therein. During use, the introducer sheath is introduced into the puncture. With the balloon in a collapsed state, the occlusion member is introduced through the introducer sheath until the balloon is disposed within the vessel. The introducer sheath is coupled to the retraction assembly, the balloon is expanded, and the occlusion member is partially withdrawn to seal the puncture. A sealing compound is delivered from the syringe assembly through the introducer sheath into the puncture, the syringe assembly triggering the retraction assembly, whereupon the introducer sheath is automatically withdrawn at least partially from the puncture, delivering the sealing compound along the puncture.

    摘要翻译： 用于密封与血管连通的穿刺的装置包括导引鞘，其上具有气囊的闭塞构件，收缩组件和其中包括密封材料的注射器组件。 在使用过程中，导引鞘被引入穿刺。 当气囊处于折叠状态时，闭塞构件通过引导器护套引入，直到球囊置于血管内。 引导器护套联接到缩回组件，气囊膨胀，并且闭塞构件被部分地抽出以密封穿刺。 密封化合物从注射器组件通过引导器护套输送到穿刺中，注射器组件触发缩回组件，于是引导器护套至少部分地从穿刺中自动抽出，沿着穿刺输送密封化合物。

    APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE
    79.
    发明申请
    APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE 有权
    用于密封血管内窥镜的装置和方法

    公开(公告)号：US20130066361A1

    公开(公告)日：2013-03-14

    申请号：US13610849

    申请日：2012-09-11

    申请人： Suresh S. Pai ,  Celso J. Bagaoisan ,  Farhad Khosravi

    发明人： Suresh S. Pai ,  Celso J. Bagaoisan ,  Farhad Khosravi

    IPC分类号： A61B17/03

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00495 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00672

    摘要： Apparatus for sealing a puncture through tissue to a blood vessel includes a cartridge including a proximal end, a distal end sized for insertion into a puncture, and a lumen extending therebetween. A bioabsorbable plug is disposed within the lumen adjacent the distal end, and an anchoring element is disposed within the lumen proximal to the plug. A pusher member is disposed within the lumen for deploying the plug and anchoring element out the distal end of the cartridge. The plug may be formed from lyophilized hydrogel and the anchoring element may be formed from air-dried hydrogel, the anchoring element hydrating slower than the plug when exposed to an aqueous environment. During use, the plug and anchoring element are delivered into the puncture, the plug is cinched against the vessel wall. Protrusions on the anchoring element engage tissue surrounding the puncture to prevent proximal movement of the plug.

    摘要翻译： 用于将穿过组织的穿刺密封到血管的装置包括：盒，其包括近端，尺寸适于插入穿刺的远端以及在其间延伸的内腔。 生物可吸收塞子设置在邻近远端的内腔内，并且锚定元件设置在靠近塞子的内腔内。 推动器构件设置在内腔内，用于将插塞和锚固元件从盒的远端伸出。 塞子可以由冻干的水凝胶形成，并且锚定元件可以由空气干燥的水凝胶形成，当暴露于水性环境时，锚定元件比塞子保持缓慢。 在使用过程中，插头和锚定元件被输送到穿刺部分中，塞子紧贴在血管壁上。 锚固元件上的突起接合穿刺周围的组织，以防止插塞的近端移动。