公开(公告)号：US10597733B2

公开(公告)日：2020-03-24

申请号：US15971561

申请日：2018-05-04

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Hatim T. Allawi

IPC: C07H21/04 ,  C12Q1/68 ,  C12Q1/6886

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.

公开(公告)号：US10519510B2

公开(公告)日：2019-12-31

申请号：US15278697

申请日：2016-09-28

Applicant: EXACT SCIENCES DEVELOPMENT COMPANY, LLC ,  MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： David A. Ahlquist ,  William R. Taylor ,  Hongzhi Zou ,  Graham P. Lidgard

IPC: C12Q1/68 ,  C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6858

Abstract: The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.

公开(公告)号：US20190330702A1

公开(公告)日：2019-10-31

申请号：US16460647

申请日：2019-07-02

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： Hatim Allawi ,  Graham P. Lidgard ,  Maria Giakoumopoulos ,  David A. Ahlquist ,  William R. Taylor ,  Douglas Mahoney

IPC: C12Q1/6886 ,  C12Q1/6806

Abstract: Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.

公开(公告)号：US10435755B2

公开(公告)日：2019-10-08

申请号：US15550703

申请日：2016-03-23

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Douglas W. Mahoney ,  Tracy C. Yab ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C07H21/04 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q1/6883 ,  G01N33/574

Abstract: Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).

公开(公告)号：US20190161804A1

公开(公告)日：2019-05-30

申请号：US16093534

申请日：2017-04-13

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney

IPC: C12Q1/6886

Abstract: Provided herein is technology for pancreatic high-grade dysplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of pancreatic high-grade dysplasia (IPMN-HGD, PanIN-3, or PDAC).

公开(公告)号：US20180245163A1

公开(公告)日：2018-08-30

申请号：US15906932

申请日：2018-02-27

Applicant: Mayo Foundation for Medical Education and Research ,  EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Brian A. Dukek ,  Matthew T. Gettman ,  Hatim T. Allawi

IPC: C12Q1/6886

Abstract: Provided herein is technology for prostate cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of prostate cancer.

公开(公告)号：US09982310B2

公开(公告)日：2018-05-29

申请号：US15243488

申请日：2016-08-22

Applicant: Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  John B. Kisiel ,  William R. Taylor ,  Tracy C. Yab ,  Douglas W. Mahoney

IPC: C12Q1/68 ,  C07H21/04

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.

公开(公告)号：US20180037958A1

公开(公告)日：2018-02-08

申请号：US15550703

申请日：2016-03-23

Applicant: Exact Sciences Corporation ,  Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Douglas W. Mahoney ,  Tracy C. Yab ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/166 ,  G01N33/57407 ,  G01N2440/12 ,  G01N2800/14

Abstract: Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).

公开(公告)号：US20170198361A1

公开(公告)日：2017-07-13

申请号：US15467739

申请日：2017-03-23

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold S. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y302/01001 ,  C12Y304/2107 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US20170058356A1

公开(公告)日：2017-03-02

申请号：US15252966

申请日：2016-08-31

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Corporation

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Hatim T. Allawi

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/16

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.

Abstract translation: 本文提供了涉及检测瘤形成的技术，特别是但不排他地涉及用于检测癌前期恶变和恶性肿瘤的方法，组合物和相关用途。