公开(公告)号：US06752922B2

公开(公告)日：2004-06-22

申请号：US10118469

申请日：2002-04-05

Applicant: Jiang Huang ,  Hou-Pu Chou ,  Marc A. Unger

Inventor： Jiang Huang ,  Hou-Pu Chou ,  Marc A. Unger

IPC: B01D1508

CPC classification number: B01D15/08 ,  G01N30/6065 ,  G01N30/6095 ,  G01N2030/387 ,  G01N2030/521 ,  Y10T137/86863 ,  Y10T436/2575

Abstract: The present invention is directed to a microfluidic chromatography apparatus comprising a microfabricated fluid delivery system and a chromatography column which is in fluid communication with the fluid delivery system, and a method for producing and using the same. Preferably, the chromatography column comprises an OTLC, PCLC, or combinations thereof.

Abstract translation: 本发明涉及包含微流体输送系统和与流体输送系统流体连通的色谱柱的微流体色谱装置及其制造和使用方法。 优选地，色谱柱包括OTLC，PCLC或其组合。

公开(公告)号：US06508988B1

公开(公告)日：2003-01-21

申请号：US09679432

申请日：2000-10-03

Applicant: R. Michael Van Dam ,  Marc A. Unger ,  Stephen R. Quake

Inventor： R. Michael Van Dam ,  Marc A. Unger ,  Stephen R. Quake

IPC: B01C300

CPC classification number: B01J19/0046 ,  B01J2219/00355 ,  B01J2219/00398 ,  B01J2219/00418 ,  B01J2219/00427 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B82Y30/00 ,  C40B40/06 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The present invention provides a chemical reaction apparatus for synthesizing an array of compounds and methods for using the same. In particular, the chemical reaction apparatus of the present invention comprises a solid support base, a first elastic member attached to the solid support base, and a first plurality of flow channels between the solid support base and the first elastic member. In addition, the solid support base comprises a functional group within at least a portion of the first plurality of flow channels for attaching compounds thereto. Optionally, the chemical reaction apparatus may further comprise a second plurality of flow channels which are in a different direction than the first plurality of flow channels. Moreover, the chemical reaction apparatus of the present invention can also include a second elastic member attached to the first elastic member. A plurality of pressure channels present in between the first and the second elastic members allows control of fluid flow within the first plurality of flow channels and/or the second plurality of flow channels.

Abstract translation: 本发明提供一种用于合成化合物阵列的化学反应装置及其使用方法。 特别地，本发明的化学反应装置包括固体支撑基底，附着到固体支撑基底的第一弹性部件和固体支撑基底与第一弹性部件之间的第一多个流动通道。 此外，固体支持物基团包括在第一多个流动通道的至少一部分内的用于将化合物附着到其上的官能团。 任选地，化学反应装置还可以包括与第一多个流动通道不同的方向的第二多个流动通道。 此外，本发明的化学反应装置还可以包括附接到第一弹性构件的第二弹性构件。 存在于第一和第二弹性构件之间的多个压力通道允许控制第一多个流动通道和/或第二多个流动通道内的流体流动。

公开(公告)号：US06408878B1

公开(公告)日：2002-06-25

申请号：US09796666

申请日：2001-02-28

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

IPC: F16K1120

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.