Combinatorial synthesis system
    1.
    发明授权
    Combinatorial synthesis system 有权
    组合综合体系

    公开(公告)号:US06508988B1

    公开(公告)日:2003-01-21

    申请号:US09679432

    申请日:2000-10-03

    IPC分类号: B01C300

    摘要: The present invention provides a chemical reaction apparatus for synthesizing an array of compounds and methods for using the same. In particular, the chemical reaction apparatus of the present invention comprises a solid support base, a first elastic member attached to the solid support base, and a first plurality of flow channels between the solid support base and the first elastic member. In addition, the solid support base comprises a functional group within at least a portion of the first plurality of flow channels for attaching compounds thereto. Optionally, the chemical reaction apparatus may further comprise a second plurality of flow channels which are in a different direction than the first plurality of flow channels. Moreover, the chemical reaction apparatus of the present invention can also include a second elastic member attached to the first elastic member. A plurality of pressure channels present in between the first and the second elastic members allows control of fluid flow within the first plurality of flow channels and/or the second plurality of flow channels.

    摘要翻译: 本发明提供一种用于合成化合物阵列的化学反应装置及其使用方法。 特别地,本发明的化学反应装置包括固体支撑基底,附着到固体支撑基底的第一弹性部件和固体支撑基底与第一弹性部件之间的第一多个流动通道。 此外,固体支持物基团包括在第一多个流动通道的至少一部分内的用于将化合物附着到其上的官能团。 任选地,化学反应装置还可以包括与第一多个流动通道不同的方向的第二多个流动通道。 此外,本发明的化学反应装置还可以包括附接到第一弹性构件的第二弹性构件。 存在于第一和第二弹性构件之间的多个压力通道允许控制第一多个流动通道和/或第二多个流动通道内的流体流动。

    Non-metric tool for predicting gene relationships from expression data
    2.
    发明授权
    Non-metric tool for predicting gene relationships from expression data 失效
    用于从表达数据预测基因关系的非度量工具

    公开(公告)号:US06947846B2

    公开(公告)日:2005-09-20

    申请号:US10289141

    申请日:2002-11-05

    CPC分类号: G06F19/20 G06F17/15 G06F19/24

    摘要: Techniques for processing gene expression data and predicting gene relationships are provided. More specifically, a method for processing gene expression ratios may include discretizing a first expression ratio for a first gene and a second expression ratio for a second gene for each of a plurality of experiments into one of three indications, calculating the probability that the combination of the discretized expression ratios for each of the plurality of experiments arises by random chance, and determining whether the first gene and the second gene are related.

    摘要翻译: 提供了处理基因表达数据和预测基因关系的技术。 更具体地,用于处理基因表达比率的方法可以包括将用于第一基因的第一表达比率和第二基因的第二表达比率分离为三个指示之一,以计算出三个指示中的一个的概率, 多个实验中的每一个的离散化表达比均由随机机会产生,并且确定第一基因和第二基因是否相关。