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公开(公告)号:US10759867B2
公开(公告)日:2020-09-01
申请号:US14130543
申请日:2012-07-06
摘要: Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as CDC-response.
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公开(公告)号:US10323081B2
公开(公告)日:2019-06-18
申请号:US14130580
申请日:2012-07-06
摘要: Provided are antibody variants having decreased or increased ability to mediate complement-dependent cytotoxicity (CDC) due to the presence or absence of C-terminal lysines of their heavy chains. Also provided are methods of generating such antibodies, as well as nucleotide constructs and host cells suitable for the production of such antibodies.
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公开(公告)号:US08182812B2
公开(公告)日:2012-05-22
申请号:US12283775
申请日:2008-09-16
申请人: Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
发明人: Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
IPC分类号: A61K39/395 , A61P37/02 , A61P37/08 , G01N33/53
CPC分类号: C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译: 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤,转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体,非人转基因动物,产生人抗体的杂交瘤和转染瘤的药物组合物,以及使用人抗体的治疗和诊断方法。
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公开(公告)号:US20100015134A1
公开(公告)日:2010-01-21
申请号:US11990581
申请日:2006-08-18
申请人: Paul Parren , Ole Baadsgaard , Denis Alexander
发明人: Paul Parren , Ole Baadsgaard , Denis Alexander
IPC分类号: A61K39/395 , C07K16/00 , A61P35/00 , A61P35/02
CPC分类号: C07K16/2812 , A61K31/37 , A61K39/395 , A61K41/0066 , A61K2039/505 , A61K2300/00
摘要: The present invention relates to a peptide, such as an antibody, capable of binding to CD4 and use thereof for the mediation of radiation treatment of a clinical condition. The radiation treatment may for instance by treatment with PUVA.
摘要翻译: 本发明涉及能够结合CD4的肽,例如抗体,以及其用于临床病症的放射治疗的介导。 放射治疗可以例如通过用PUVA处理。
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公开(公告)号:US07622559B2
公开(公告)日:2009-11-24
申请号:US11823481
申请日:2007-06-27
申请人: Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jørgen Petersen
发明人: Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jørgen Petersen
IPC分类号: A61K39/00
CPC分类号: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
摘要: Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译: 公开了与IL-8结合的分离的人单克隆抗体(例如人IL-8)。 人抗体可以通过进行V-D-J重组和同种型转换,在能够产生人单克隆抗体多重同种型的杂交瘤,转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体,非人转基因动物,杂交瘤和产生人抗体的转染瘤的药物组合物,以及使用人抗体的治疗和诊断方法。
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公开(公告)号:US20090155204A1
公开(公告)日:2009-06-18
申请号:US12291494
申请日:2008-11-11
IPC分类号: A61K38/20 , A61K39/395
CPC分类号: C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , Y02A50/41
摘要: Methods for treating disorders involving monocytic activity by administering IL-15 antagonists that induce apoptosis of monocytes are disclosed.
摘要翻译: 公开了通过施用诱导单核细胞凋亡的IL-15拮抗剂来治疗涉及单核细胞活性的疾病的方法。
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公开(公告)号:US07438907B2
公开(公告)日:2008-10-21
申请号:US10714353
申请日:2003-11-14
申请人: Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
发明人: Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
IPC分类号: A61K39/00 , A61K39/395 , C07K16/00
CPC分类号: C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译: 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤,转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体,非人转基因动物,产生人抗体的杂交瘤和转染瘤的药物组合物,以及使用人抗体的治疗和诊断方法。
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公开(公告)号:US09085625B2
公开(公告)日:2015-07-21
申请号:US13132423
申请日:2009-12-03
申请人: Aran Frank Labrijn , Stefan Loverix , Paul Parren , Jau Van De Winkel , Janine Schuurman , Lgnace Laster
发明人: Aran Frank Labrijn , Stefan Loverix , Paul Parren , Jau Van De Winkel , Janine Schuurman , Lgnace Laster
CPC分类号: C07K16/2863 , A61K39/3955 , A61K47/6849 , A61K51/103 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/76
摘要: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
摘要翻译: 本发明涉及抗体的恒定区,特别是IgG4的CH3区的位置,其影响了CH3-CH3相互作用的强度。 公开了稳定或不稳定这种相互作用的突变。
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公开(公告)号:US20110293607A1
公开(公告)日:2011-12-01
申请号:US13132423
申请日:2009-12-03
申请人: Aran Frank Labrijn , Stefan Loverix , Paul Parren , Jau Van De Winkel , Janine Schuurman , Lgnace Laster
发明人: Aran Frank Labrijn , Stefan Loverix , Paul Parren , Jau Van De Winkel , Janine Schuurman , Lgnace Laster
IPC分类号: A61K39/395 , C12P21/02 , C07K16/00 , C07K16/22 , C07K16/24 , C07K16/28 , C07K16/36 , C07K16/40 , C07K16/44 , C07K16/26 , C07K16/42 , C07K16/08 , C07K16/10 , A61K31/7088 , A61P35/00 , A61P29/00 , C12N15/63
CPC分类号: C07K16/2863 , A61K39/3955 , A61K47/6849 , A61K51/103 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/76
摘要: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
摘要翻译: 本发明涉及抗体的恒定区,特别是IgG4的CH3区的位置,其影响了CH3-CH3相互作用的强度。 公开了稳定或不稳定这种相互作用的突变。
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公开(公告)号:US20100041874A1
公开(公告)日:2010-02-18
申请号:US12443918
申请日:2007-10-02
CPC分类号: G01N33/5008 , C07K16/2896 , C07K2317/77 , G01N33/5014 , G01N33/5052
摘要: The invention relates to methods for the characterization of monoclonal antibodies, in particular high throughput methods for the characterization of antibodies with respect to internalization and complement activation.
摘要翻译: 本发明涉及用于表征单克隆抗体的方法,特别是关于针对内化和补体激活表征抗体的高通量方法。
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