公开(公告)号：US20100047318A1

公开(公告)日：2010-02-25

申请号：US12195789

申请日：2008-08-21

申请人： Mukesh Kumar

发明人： Mukesh Kumar

IPC分类号： A61K9/00 ,  A61P43/00

CPC分类号： A61K9/0024 ,  A61K9/5031

摘要： Implantable compositions capable of providing release of bioactive agents according to a predetermined release profile and methods for their use. Such compositions include at least one ceramic substrate; a bioactive substance loaded on a surface of a said ceramic substrate forming a loaded surface zone operable to release said bioactive substance according to a release profile under physiological conditions; and a biodegradable polymer having an in vivo degradation period, forming a continuous or discontinuous coating on an area of a said ceramic substrate. The composition comprises at least two said loaded surface zones having different release profiles, or at least two said coatings having different in vivo degradation periods.

摘要翻译： 能够根据预定释放特征提供生物活性剂释放的植入物组合物及其使用方法。 这样的组合物包括至少一个陶瓷衬底; 负载在所述陶瓷基材的表面上的生物活性物质，其形成负载表面区域，其可操作以在生理条件下根据释放曲线释放所述生物活性物质; 以及具有体内降解期的可生物降解聚合物，在所述陶瓷基材的区域上形成连续或不连续的涂层。 所述组合物包含至少两个所述负载的表面区域具有不同的释放曲线，或至少两个所述涂层具有不同的体内降解期。

公开(公告)号：US20060226076A1

公开(公告)日：2006-10-12

申请号：US11449476

申请日：2006-06-08

申请人： Anand Burman ,  Rama Mukherjee ,  Dinesh Kumar ,  Dhiraj Khattar ,  Mukesh Kumar ,  Praveen Khullar ,  Perundurai Srinivasan ,  Rajesh Srivastava

发明人： Anand Burman ,  Rama Mukherjee ,  Dinesh Kumar ,  Dhiraj Khattar ,  Mukesh Kumar ,  Praveen Khullar ,  Perundurai Srinivasan ,  Rajesh Srivastava

IPC分类号： B01D15/08

CPC分类号： C07D305/14 ,  A61K47/44 ,  B01D15/325 ,  B01J20/287

摘要： A stabilized pharmaceutical composition of anticancer drug and a solvent like Polyethoxylated castor oil (cremophor) also containing any other suitable solubilizer suitable for human administration like dehydrated alcohol, is disclosed. Compositions prepared using this purified polyethoxylated castor oil enhance the stability of paclitaxel in such compositions.

摘要翻译： 公开了一种稳定的抗癌药物和溶剂，如聚乙氧基化蓖麻油（cremophor）的药物组合物，其也含有适于人类给药的任何其它合适的增溶剂如脱水醇。 使用该纯化的聚乙氧基化蓖麻油制备的组合物增强紫杉醇在这些组合物中的稳定性。

公开(公告)号：US07118888B2

公开(公告)日：2006-10-10

申请号：US10073065

申请日：2002-02-12

申请人： Shyam S. Mohapatra ,  Mukesh Kumar ,  Shua-ku Huang ,  Kam Leong

发明人： Shyam S. Mohapatra ,  Mukesh Kumar ,  Shua-ku Huang ,  Kam Leong

IPC分类号： C12P21/06

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/53 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/544 ,  A61K2039/55583 ,  C12N2760/18522 ,  C12N2760/18534

摘要： An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to formulate nanospheres. In a murine model of RSV infection, intranasal administration with GXV results in significant induction of RSV-specific antibodies, nasal IgA antibodies, cytotoxic T lymphocytes, and IFN-γ production in the lung and splenocytes. A single dose of GXV induces a drastic reduction of viral titers.

公开(公告)号：US20060198943A1

公开(公告)日：2006-09-07

申请号：US11366727

申请日：2006-03-02

申请人： Mukesh Kumar

发明人： Mukesh Kumar

IPC分类号： A61L27/32 ,  B05D1/02 ,  B05D1/08

CPC分类号： A61L27/306

摘要： A method for forming an acetabular shell includes providing a working surface such as a mandrel, and spraying the working surface with a first layer of material having a first composition such as aluminum oxide. After a suitable thickness is generated, the spray composition is gradually changed to other compositions having desired particle sizes and distribution. In one example, the composition is changed to a mixture of aluminum oxide and titanium oxide and/or titanium. As thickness builds up, the relative amount of aluminum oxide is decreased such that the composition is all titanium and titanium oxide. After a desired thickness is generated, the acetabular shell is extracted off the mandrel.

摘要翻译： 一种用于形成髋臼壳的方法包括提供诸如心轴的工作表面，并且用具有第一组成的第一层材料如氧化铝喷涂工作表面。 在产生合适的厚度之后，将喷雾组合物逐渐变为具有所需粒度和分布的其它组合物。 在一个实例中，将组合物改变为氧化铝和氧化钛和/或钛的混合物。 随着厚度的增加，氧化铝的相对量降低，使得组合物全部为钛和氧化钛。 在产生期望的厚度之后，将髋臼壳从芯轴上取出。

公开(公告)号：US20060159783A1

公开(公告)日：2006-07-20

申请号：US11219482

申请日：2005-09-02

申请人： Rama Mukherjee ,  Dhiraj Khattar ,  Manu Jaggi ,  Anu Singh ,  Mukesh Kumar ,  Honey Bala

发明人： Rama Mukherjee ,  Dhiraj Khattar ,  Manu Jaggi ,  Anu Singh ,  Mukesh Kumar ,  Honey Bala

IPC分类号： A61K36/906

CPC分类号： A61K31/56 ,  A61K36/725

摘要： This invention relates to an orally effective herbal extract-based composition having broad-spectrum anticancer activity, more specifically a method of treating, inhibiting and/or preventing malignant tumors of the colon, intestine, stomach, breast, melanoma, glioblastoma, lung, cervix, ovary, prostate, oral cavity, larynx, liver, pancreas, kidney, bladder, endothelial cells, leukemia and myeloma using a herbal extract of Zizyphus, rich in betulinic acid. An advantage of the extract is that the betulinic acid has low systemic toxicity. The extract inhibits Protein Kinase C activity of cancer cells and induces apoptosis.

摘要翻译： 本发明涉及具有广谱抗癌活性的口服有效的草药提取物组合物，更具体地，涉及治疗，抑制和/或预防结肠，肠，胃，乳腺，黑素瘤，成胶质细胞瘤，肺，子宫颈恶性肿瘤的方法 ，卵巢，前列腺，口腔，喉，肝，胰腺，肾，膀胱，内皮细胞，白血病和骨髓瘤，使用梓属的草药提取物，富含桦木酸。 提取物的优点是桦木酸具有低的全身毒性。 提取物抑制癌细胞的蛋白激酶C活性并诱导细胞凋亡。

公开(公告)号：US20050077252A1

公开(公告)日：2005-04-14

申请号：US10684718

申请日：2003-10-14

申请人： George Shih ,  William Schwartz ,  Chendong Huang ,  Mukesh Kumar ,  Byung Kim ,  Sherry Mueller ,  Vijay Garg

发明人： George Shih ,  William Schwartz ,  Chendong Huang ,  Mukesh Kumar ,  Byung Kim ,  Sherry Mueller ,  Vijay Garg

IPC分类号： B01D36/00 ,  H01M8/04

CPC分类号： H01M8/04029 ,  H01M8/04044

摘要： A flush and fill process is used to ready a fuel cell cooling circuit for initial use. An external flushing system relasably connected to the cooling circuit circulates flushing coolant through the cooling circuit to remove contaminants from the wetted surfaces of the cooling circuit before the fuel cell is put into use. The flushing system includes a pump for circulating the flushing coolant through the cooling circuit, filters for removing contaminants from the coolant and a heater for elevating the temperature of the coolant. Following the flushing process to remove contaminants, the flushing system is disconnected from the cooling circuit and the cooling circuit is filled with fresh coolant.

摘要翻译： 使用冲洗和填充过程来准备燃料电池冷却回路以便初始使用。 可靠地连接到冷却回路的外部冲洗系统使冲洗冷却剂循环通过冷却回路，以在燃料电池投入使用之前从冷却回路的润湿表面去除污染物。 冲洗系统包括用于使冲洗冷却剂循环通过冷却回路的泵，用于从冷却剂中除去污染物的过滤器和用于升高冷却剂温度的加热器。 在冲洗过程中除去污染物后，冲洗系统与冷却回路断开连接，冷却回路充满新鲜的冷却液。

公开(公告)号：US20050037030A1

公开(公告)日：2005-02-17

申请号：US10498407

申请日：2002-12-12

申请人： Mukesh Kumar ,  Ajay Singla ,  Vinod Arora ,  Rajiv Malik

发明人： Mukesh Kumar ,  Ajay Singla ,  Vinod Arora ,  Rajiv Malik

IPC分类号： A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61K31/7048

CPC分类号： A61K31/7048 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/107

摘要： This invention relates to a stable topical formulation of clarithromycin and its use in the treatment of acne.

摘要翻译： 本发明涉及克拉霉素的稳定局部制剂及其在治疗痤疮中的用途。

公开(公告)号：US09754000B2

公开(公告)日：2017-09-05

申请号：US13724565

申请日：2012-12-21

申请人： Olga Kreindlina ,  Oliver Berger ,  Santhosh N ,  Karthik Narayanan Mohan ,  Walter Zimmermann ,  Torsten Buecheler ,  Sophie Kraut ,  Albert Neumueller ,  Steffen Witt ,  Dietmar Henkes ,  Guang Yang ,  Thomas Vogt ,  Matthias Becker ,  Martin Haerterich ,  Stefan Moeller ,  Kritesh Vasing ,  Knut Heusermann ,  Christian Hohmann ,  Marcus Echter ,  Xenia Rieger ,  Mohit V. Gadkari ,  Mukesh Kumar

发明人： Olga Kreindlina ,  Oliver Berger ,  Santhosh N ,  Karthik Narayanan Mohan ,  Walter Zimmermann ,  Torsten Buecheler ,  Sophie Kraut ,  Albert Neumueller ,  Steffen Witt ,  Dietmar Henkes ,  Guang Yang ,  Thomas Vogt ,  Matthias Becker ,  Martin Haerterich ,  Stefan Moeller ,  Kritesh Vasing ,  Knut Heusermann ,  Christian Hohmann ,  Marcus Echter ,  Xenia Rieger ,  Mohit V. Gadkari ,  Mukesh Kumar

IPC分类号： G06F7/00 ,  G06F17/00 ,  G06F17/30

CPC分类号： G06F17/30575 ,  G06F17/30569

摘要： According to one general aspect, a method may include replicating, to a software-as-a-service application, a plurality of pieces of master data from a physically remote master database. The method may also include converting the plurality of pieces of master data into one or more pieces of local data of the software-as-a-service application. The method may include changing one or more of either the pieces of master data or the pieces of local data. The method may further include synchronizing the changed pieces of either master data or local data between the remote master database and the software-as-a-service application.

公开(公告)号：US08771364B2

公开(公告)日：2014-07-08

申请号：US12253259

申请日：2008-10-17

申请人： Brian M. May ,  Mukesh Kumar

发明人： Brian M. May ,  Mukesh Kumar

IPC分类号： A61F2/38

CPC分类号： A61F2/38 ,  A61F2002/30013 ,  A61F2002/30377 ,  A61F2002/30387 ,  A61F2002/3092 ,  A61F2002/3093 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2250/0024 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00131 ,  A61F2310/00976

摘要： A knee joint prosthesis can include a tibial component that can have a tibial tray. The tibial tray can include a platform-like tray that defines a superior surface and an inferior surface. The platform-like tray can have a tray perimeter and a raised wall formed on the inferior surface. The raised wall can be offset inboard relative to the tray perimeter. Porous material can be disposed on the inferior surface of the platform-like tray at a location generally between the raised wall and the tray perimeter.

摘要翻译： 膝关节假体可以包括可具有胫骨托的胫骨部件。 胫骨托可包括限定上表面和下表面的平台状托盘。 平台状托盘可以具有托盘周边和形成在下表面上的凸起壁。 凸起的壁可以相对于托盘周边在内侧偏移。 多孔材料可以在通常在凸起壁和托盘周边之间的位置处设置在平台状托盘的下表面上。

公开(公告)号：US08745997B2

公开(公告)日：2014-06-10

申请号：US13151519

申请日：2011-06-02

申请人： Mukesh Kumar ,  Debasish Dhar ,  Mitali Chakrabarti ,  Ken J. Jackson ,  Manfred Koberstein

发明人： Mukesh Kumar ,  Debasish Dhar ,  Mitali Chakrabarti ,  Ken J. Jackson ,  Manfred Koberstein

IPC分类号： B60H1/32 ,  F25B49/00

CPC分类号： B60H1/322 ,  B60H2001/3266 ,  B60H2001/3275 ,  F02N11/0814 ,  F25B27/00 ,  F25B49/02 ,  F25B49/022 ,  F25B2327/001 ,  F25B2600/023 ,  F25B2600/112 ,  F25B2700/2104 ,  F25B2700/2106 ,  F25B2700/2117

摘要： An air conditioning system for a start-stop vehicle employs a compressor with a variable displacement. A controller determines a normal Climate Thermal Load (CTL) value for controlling a variable stroke of the variable displacement compressor. A stop event is detected in response to a speed of the vehicle and the occurrence of a predetermined deceleration. During the stop event, the variable stroke is increased by an amount determined in response to the normal CTL value, the speed of the vehicle, and a measure of the deceleration of the vehicle so that an evaporator temperature within the air conditioning system is allowed to decrease while the vehicle is stopping so that climate comfort can be maintained even while the engine is shut off during the subsequent time that the vehicle is stopped.

摘要翻译： 用于起停车辆的空调系统采用具有可变排量的压缩机。 控制器确定用于控制可变排量压缩机的可变冲程的正常气候热负荷（CTL）值。 响应于车辆的速度和发生预定的减速度来检测停止事件。 在停止事件期间，可变行程增加响应于正常CTL值，车辆速度和车辆减速度测量所确定的量，使得空调系统内的蒸发器温度被允许 当车辆停止时减少，使得即使在发动机在随后的车辆停止期间被关闭的情况下也能够保持气候舒适度。