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71.发明授权Device, method and computer program product for carrying out integrity tests on filter elements 有权用于对过滤元件执行完整性测试的设备，方法和计算机程序产品公开(公告)号：US07281409B2
公开(公告)日：2007-10-16
申请号：US10492263
申请日：2002-10-14
IPC分类号： G01N15/08
CPC分类号： G01N15/0826 , B01D46/0086 , B01D2201/56 , B01D2273/18
摘要： The invention relates to a device for carrying out integrity tests on filter elements by means of test gases, comprising a device housing (3), with an electronic controller (4), arranged therein for regulation and control of the progress of a test programme for filter elements, a filter housing (6), for housing a filter element (2) under test, a pneumatic unit (5), connected to the controller (4) and the filter housing (6), in particular for the generation and measurement of gas pressures, an electronic memory unit (10), which may be connected to the filter element (2) under test and a communication unit (13′), connected to the controller (4), for the exchange of data between the controller (4) and the electronic memory element (10). The communication unit (13′) is preferably embodied as an antenna (14′) and the electronic memory element (10) as a transponder (11). In addition to the device a method for carrying out integrity tests and a computer programme product are also disclosed.
摘要翻译： 本发明涉及一种用于通过测试气体对过滤元件执行完整性测试的装置，包括设置有用于调节和控制测试程序进度的装置壳体（3），其中安装有电子控制器（4） 过滤器元件，用于容纳被测试的过滤元件（2）的过滤器壳体（6），连接到控制器（4）和过滤器壳体（6）的气动单元（5），特别是用于产生和测量 的气体压力的电子存储器单元（10），可连接到被测试的过滤元件（2）的电子存储器单元（10）和连接到控制器（4）的通信单元（13'），用于在控制器 （4）和电子存储元件（10）。 通信单元（13'）优选地被实施为天线（14'）和作为应答器（11）的电子存储元件（10）。 此外，还公开了用于执行完整性测试的方法和计算机程序产品。
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72.发明申请Apparatus for removing samples from systems having flexible walls and for introducing fluids into the same 有权用于从具有柔性壁的系统中去除样品并将流体引入其中的装置公开(公告)号：US20070227270A1
公开(公告)日：2007-10-04
申请号：US11713978
申请日：2007-03-05
IPC分类号： G01N1/14
CPC分类号： G01N35/1079 , A61J1/12 , A61J1/20 , C12M33/00 , C12M37/04 , G01N2001/1056
摘要： The invention discloses an apparatus for removing samples or introducing fluids from/into system(s) having flexible walls. A sampler/fluid dispenser (3) is fixed on the outside with a connecting area (4) of its base (5) on a sample removal region/fluid dispensing region (6) of the flexible wall (2) and, in its interior, has a severing element (8). At least the severing element (8) can be pushed forward in the direction of the sample removal region/fluid dispensing region (6) in order to remove the samples and in order to introduce fluids, in such a way that the wall (2) can be perforated within the sample removal region/fluid dispensing region (6). The system (1) comprises containers, bags or tubes for filling, mixing, transporting, storage of media, such as biological liquids, sera, buffers, ultra-pure water and can be used as biological reactors or cell culture vessels in the pharmaceutical and biotechnical industry.
摘要翻译： 本发明公开了一种用于从具有柔性壁的系统中去除样品或将流体从/进入系统的装置。 取样器/流体分配器（3）在其外部固定有其基部（5）的连接区域（4）在柔性壁（2）的样品移除区域/流体分配区域（6）上，并且在其内部 ，具有切断要素（8）。 至少切断元件（8）可以沿着样品移除区域/流体分配区域（6）的方向向前推动，以便去除样品并且以这样的方式引入流体：壁（2） 可以在样品去除区域/流体分配区域（6）内穿孔。 系统（1）包括用于填充，混合，运输，储存诸如生物液体，血清，缓冲液，超纯水的介质的容器，袋或管，并可用作药物和/或制剂中的生物反应器或细胞培养容器 生物工业。
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73.发明申请Purification of high-molecular compounds by means of affinity membrane chromatography 审中-公开通过亲和膜层析纯化高分子化合物公开(公告)号：US20070178576A1
公开(公告)日：2007-08-02
申请号：US10587064
申请日：2005-01-27
申请人： Wolfgang Demmer , Matthias Grabosch , Oscar-Werner Reif , Wolfgan Nagel , Mariel Donzeau , Peter Reichelt
发明人： Wolfgang Demmer , Matthias Grabosch , Oscar-Werner Reif , Wolfgan Nagel , Mariel Donzeau , Peter Reichelt
CPC分类号： C12N7/00 , A61K2039/5256 , C07K1/22 , C07K14/005 , C12N2795/14122 , C12N2795/14151
摘要： The invention relates to a method for purifying and/or isolating high-molecular compounds, such as high-molecular proteins or protein-type compounds, contained in a solution or a suspension, by means of affinity chromatography using membranes containing metal ions.
摘要翻译： 本发明涉及通过使用含有金属离子的膜的亲和层析来纯化和/或分离包含在溶液或悬浮液中的高分子化合物，例如高分子蛋白质或蛋白质类型化合物的方法。
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公开(公告)号：US20070160500A1
公开(公告)日：2007-07-12
申请号：US11651823
申请日：2007-01-10
IPC分类号： G01N21/64
CPC分类号： G01N21/274 , G01N21/0332 , G01N21/7703 , G01N2021/7786
摘要： The invention relates to a sensor for measuring an oxygen content in a liquid or gaseous sample, comprising a first sensor section (14a) that can be brought into contact with the sample and has a luminescent indicator dye embedded in an oxygen-permeable, first polymer matrix, light guiding means (10) for guiding luminescence excitation light from a light source (31, 32) to the first sensor section (14a), and light guiding means (10) for guiding luminescence emission light from the first sensor section (14a) to a detector (39). The invention is distinguished in that arranged adjacent to the first sensor section (14a) is a second sensor section (14b) that includes the same dye, embedded in an oxygen-impermeable, second polymer matrix.
摘要翻译： 本发明涉及一种用于测量液体或气体样品中氧含量的传感器，包括可与样品接触的第一传感器部分（14a），并且具有嵌入氧气可渗透的第一传感器部分 聚合物基体，用于将来自光源（31,32）的发光激发光引导到第一传感器部分（14a）的导光装置（10），以及用于引导来自第一传感器部分的发光发射光的导光装置 （14a）到检测器（39）。 本发明的区别在于邻近第一传感器部分（14a）布置的是包含相同染料的第二传感器部分（14b），其嵌入在不透氧的第二聚合物基质中。
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公开(公告)号：US06959812B2
公开(公告)日：2005-11-01
申请号：US10214896
申请日：2002-08-07
申请人： Oscar-Werner Reif , Andreas Graus
发明人： Oscar-Werner Reif , Andreas Graus
CPC分类号： A61M5/002 , A61M5/165 , A61M5/3145 , A61M2209/06 , B65D2577/2091
摘要： There is disclosed a filter package comprising a housing and a cover that is adapted to enclose a sterile disposable filter wherein the package cover is penetrable at a point axially aligned with the filter and has at least one pre-formed break line along which the package cover, when subjected to appropriate force, ruptures so as to permit withdrawal of the filter by a syringe coupled thereto.
摘要翻译： 公开了一种过滤器包装，其包括壳体和盖，其适于包围无菌一次性过滤器，其中包装盖可在与过滤器轴向对准的点处穿透，并且具有至少一个预先形成的断裂线，包装盖 当受到适当的力时，破裂以允许通过与其连接的注射器抽出过滤器。
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76.发明申请Device, method and computer programmme product for carrying out integrity tests on filter elements 有权用于对过滤元件进行完整性测试的设备，方法和计算机程序产品公开(公告)号：US20050027484A1
公开(公告)日：2005-02-03
申请号：US10492263
申请日：2002-10-14
CPC分类号： G01N15/0826 , B01D46/0086 , B01D2201/56 , B01D2273/18
摘要： The invention relates to a device for carrying out integrity tests on filter elements by means of test gases, comprising a device housing (3), with an electronic controller (4), arranged therein for regulation and control of the progress of a test programme for filter elements, a filter housing (6), for housing a filter element (2) under test, a pneumatic unit (5), connected to the controller (4) and the filter housing (6), in particular for the generation and measurement of gas pressures, an electronic memory unit (10), which may be connected to the filter element (2) under test and a communication unit (13′), connected to the controller (4), for the exchange of data between the controller (4) and the electronic memory element (10). The communication unit (13′) is preferably embodied as an antenna (14′) and the electronic memory element (10) as a transponder (11). In addition to the device a method for carrying out integrity tests and a computer programme product are also disclosed.
摘要翻译： 本发明涉及一种用于通过测试气体对过滤元件执行完整性测试的装置，包括设置有用于调节和控制测试程序进度的装置壳体（3），其中安装有电子控制器（4） 过滤器元件，用于容纳被测试的过滤元件（2）的过滤器壳体（6），连接到控制器（4）和过滤器壳体（6）的气动单元（5），特别是用于产生和测量 的气体压力的电子存储器单元（10），可连接到被测试的过滤元件（2）的电子存储器单元（10）和连接到控制器（4）的通信单元（13'），用于在控制器 （4）和电子存储元件（10）。 通信单元（13'）优选地被实施为天线（14'）和作为应答器（11）的电子存储元件（10）。 此外，还公开了用于执行完整性测试的方法和计算机程序产品。
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77.发明授权Integrity testable filtration unit using supported hydrophilic porous membranes 失效使用支撑的亲水性多孔膜的完整性可测试过滤单元公开(公告)号：US06186341B1
公开(公告)日：2001-02-13
申请号：US09083562
申请日：1998-05-22
IPC分类号： B01D2900
CPC分类号： B01D63/061 , B01D63/067 , B01D65/003
摘要： The hydrophilicity of porous separation membranes is maintained by bonding the membranes to thermoplastic fiber substrates at least on their peripheries before the membrane peripheries are sealed in a thermoplastic resin. The membranes are capable of being integrity tested.
摘要翻译： 多孔分离膜的亲水性通过在膜周围被密封在热塑性树脂中之前至少在它们的周围粘合到热塑性纤维基材来保持。 膜能够进行完整性测试。
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