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公开(公告)号：US6153189A
公开(公告)日：2000-11-28
申请号：US156923
申请日：1998-09-18
申请人： Leonard G. Presta , David L. Shelton , Roman Ufer
发明人： Leonard G. Presta , David L. Shelton , Roman Ufer
IPC分类号： G01N33/53 , A61K38/00 , A61K38/55 , A61K39/395 , A61P1/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/18 , A61P25/28 , A61P29/00 , A61P35/00 , C07H21/04 , C07K14/705 , C07K14/71 , C07K16/28 , C07K19/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68
CPC分类号： C07K19/00 , C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： The invention concerns human trkB and trkC receptors and their functional derivatives. The invention further concerns immunoadhesins comprising trk receptor sequences fused to immunoglobulin sequences.
摘要翻译： 本发明涉及人trkB和trkC受体及其功能衍生物。 本发明还涉及包含与免疫球蛋白序列融合的trk受体序列的免疫粘附素。
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公开(公告)号：US06133426A
公开(公告)日：2000-10-17
申请号：US26985
申请日：1998-02-20
CPC分类号： A61K47/48215 , C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2319/00
摘要： Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment.
摘要翻译： 描述了用于诊断应用和治疗炎性疾病的人源化抗IL-8单克隆抗体及其变体。 还描述了由共价连接到非蛋白质聚合物上的抗体片段形成的缀合物，其中缀合物的表观尺寸为至少约500kD。 与未衍生的亲本抗体片段相比，缀合物显示出显着改善的循环中的半衰期，平均停留时间和/或清除率。
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73.发明授权Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life 失效多肽被改变以含有来自IgG分子的Fc区的表位，以增加半衰期
公开(公告)号：US6096871A
公开(公告)日：2000-08-01
申请号：US422093
申请日：1995-04-14
IPC分类号： C12N15/09 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/27 , A61K39/395 , A61P37/02 , C07K4/12 , C07K14/48 , C07K14/61 , C07K16/00 , C07K16/28 , C12N1/21 , C12N15/12 , C12N15/13 , C12N15/63 , C12P21/02 , C12P21/08 , C12R1/19
CPC分类号： C07K16/2845 , C07K14/48 , C07K14/61 , C07K16/00 , A61K38/00 , C07K2317/54 , C07K2317/55 , C07K2317/624 , C07K2319/00
摘要： Polypeptides that are cleared from the kidney and do not contain in their original form a Fc region of an IgG are altered so as to comprise a salvage receptor binding epitope of an Fc region of an IgG and thereby have increased circulatory half-life.
摘要翻译： 从肾脏中清除并且不以其原始形式含有IgG的Fc区的多肽被改变，以便包含IgG的Fc区的补救受体结合表位，从而具有增加的循环半衰期。
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公开(公告)号：US6025158A
公开(公告)日：2000-02-15
申请号：US27449
申请日：1998-02-20
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2319/00
摘要： Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment.
摘要翻译： 描述了用于诊断应用和治疗炎性疾病的人源化抗IL-8单克隆抗体及其变体。 还描述了由共价连接到非蛋白质聚合物上的抗体片段形成的缀合物，其中缀合物的表观尺寸为至少约500kD。 与未衍生的亲本抗体片段相比，缀合物显示出显着改善的循环中的半衰期，平均停留时间和/或清除率。
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公开(公告)号：US08580938B2
公开(公告)日：2013-11-12
申请号：US13532131
申请日：2012-06-25
IPC分类号： C07H21/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/244 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention relates to binding compounds that specifically bind to human TSLP, as well as uses thereof, e.g., in the treatment of inflammatory disorders.
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公开(公告)号：US08404813B2
公开(公告)日：2013-03-26
申请号：US13031544
申请日：2011-02-21
申请人： Leonard G. Presta
发明人： Leonard G. Presta
IPC分类号： C07K16/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K14/54 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： Engineered antibodies to human IL-23p19 are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders.
摘要翻译： 提供了针对人IL-23p19的工程抗体，以及其用途，例如， 治疗炎症，自身免疫和增殖性疾病。
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公开(公告)号：US20130039916A1
公开(公告)日：2013-02-14
申请号：US13530854
申请日：2012-06-22
IPC分类号： A61K39/395 , C12N15/13 , A61P37/06 , A61P29/00 , A61P19/02 , C12P21/02 , A61P1/00 , A61P25/00 , A61P19/04 , A61P3/10 , A61P35/00 , C07K16/24 , A61P17/06
CPC分类号： A61K45/06 , A61K2039/505 , C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Engineered antibodies to human IL-23p19 are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders.
摘要翻译： 提供了针对人IL-23p19的工程抗体，以及其用途，例如， 治疗炎症，自身免疫和增殖性疾病。
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公开(公告)号：US20120219565A1
公开(公告)日：2012-08-30
申请号：US13505340
申请日：2010-11-02
申请人： Leonard G. Presta
发明人： Leonard G. Presta
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/244 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention relates to binding compounds that specifically bind to human TSLP, as well as uses thereof, e.g., in the treatment of inflammatory disorders and allergic inflammatory response.
摘要翻译： 本发明涉及特异性结合人TSLP的结合化合物及其用途，例如用于治疗炎性疾病和过敏性炎症反应。
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公开(公告)号：US08212008B2
公开(公告)日：2012-07-03
申请号：US12520033
申请日：2007-12-20
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/2803 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to binding compounds specific for the human inhibitory CD200R and uses thereof. More specifically, the invention relates to antibodies that recognize the human inhibitory CD200R and modulates its activity in inflammatory and autoimmune disorders.
摘要翻译： 本发明涉及对人抑制性CD200R特异性的结合化合物及其用途。 更具体地，本发明涉及识别人抑制性CD200R并调节其在炎性和自身免疫性疾病中的活性的抗体。
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公开(公告)号：US20110206663A1
公开(公告)日：2011-08-25
申请号：US13034551
申请日：2011-02-24
IPC分类号： A61K39/395 , C07K16/24 , C07H21/00 , C12N15/63 , C12N1/00 , C12N5/10 , C12P21/00 , C12N5/12 , G01N33/53 , A61P37/06
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/564 , G01N33/6866 , G01N2333/56 , G01N2800/042 , G01N2800/24
摘要： The present invention relates generally to the generation and characterization of neutralizing anti-IFN-α monoclonal antibodies with broad reactivity against various IFN-α subtypes. The invention further relates to the use of such anti-IFN-α antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-α, in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
摘要翻译： 本发明一般涉及对各种IFN-α亚型具有广泛反应性的中和抗IFN-α单克隆抗体的产生和表征。 本发明还涉及这种抗-IFN-α抗体在诊断和治疗与增加的IFN-α表达有关的病症中的用途，特别是自身免疫性疾病如胰岛素依赖性糖尿病（IDDM）和系统性红斑狼疮 （SLE）。
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