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公开(公告)号：US20110268727A1
公开(公告)日：2011-11-03
申请号：US12882980
申请日：2010-09-15
IPC分类号： A61K39/395 , C07H21/04 , A61P3/10 , A61P5/14 , A61P19/04 , G01N33/577 , C12N15/63 , C12N5/10 , C12N5/16 , C12N1/21 , C12P21/08 , C12P21/02 , C07K16/24 , A61P7/06
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/564 , G01N33/6866 , G01N2333/56 , G01N2800/042 , G01N2800/24
摘要： The present invention relates generally to the generation and characterization of neutralizing anti-IFN-α monoclonal antibodies with broad reactivity against various IFN-α subtypes. The invention further relates to the use of such anti-IFN-α antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-α, in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
摘要翻译： 本发明一般涉及对各种IFN-α亚型具有广泛反应性的中和抗IFN-α单克隆抗体的产生和表征。 本发明还涉及这种抗-IFN-α抗体在诊断和治疗与增加的IFN-α表达有关的病症中的用途，特别是自身免疫性疾病如胰岛素依赖性糖尿病（IDDM）和系统性红斑狼疮 （SLE）。
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公开(公告)号：US07087726B2
公开(公告)日：2006-08-08
申请号：US10044896
申请日：2002-01-09
IPC分类号： C07K16/00
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/564 , G01N33/6866 , G01N2333/56 , G01N2800/042 , G01N2800/24
摘要： The present invention relates generally to the generation and characterization of neutralizing anti-IFN-α monoclonal antibodies with broad reactivity against various IFN-α subtypes. The invention further relates to the use of such anti-IFN-α antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-α, in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
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公开(公告)号：US08557967B2
公开(公告)日：2013-10-15
申请号：US13476878
申请日：2012-05-21
IPC分类号： C07K16/00
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/564 , G01N33/6866 , G01N2333/56 , G01N2800/042 , G01N2800/24
摘要： The present invention relates generally to the generation and characterization of neutralizing anti-IFN-α monoclonal antibodies with broad reactivity against various IFN-α subtypes. The invention further relates to the use of such anti-IFN-α antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-α, in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
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公开(公告)号：US20110206663A1
公开(公告)日：2011-08-25
申请号：US13034551
申请日：2011-02-24
IPC分类号： A61K39/395 , C07K16/24 , C07H21/00 , C12N15/63 , C12N1/00 , C12N5/10 , C12P21/00 , C12N5/12 , G01N33/53 , A61P37/06
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/564 , G01N33/6866 , G01N2333/56 , G01N2800/042 , G01N2800/24
摘要： The present invention relates generally to the generation and characterization of neutralizing anti-IFN-α monoclonal antibodies with broad reactivity against various IFN-α subtypes. The invention further relates to the use of such anti-IFN-α antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-α, in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
摘要翻译： 本发明一般涉及对各种IFN-α亚型具有广泛反应性的中和抗IFN-α单克隆抗体的产生和表征。 本发明还涉及这种抗-IFN-α抗体在诊断和治疗与增加的IFN-α表达有关的病症中的用途，特别是自身免疫性疾病如胰岛素依赖性糖尿病（IDDM）和系统性红斑狼疮 （SLE）。
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公开(公告)号：US08349331B2
公开(公告)日：2013-01-08
申请号：US13034551
申请日：2011-02-24
IPC分类号： A61K39/395
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/564 , G01N33/6866 , G01N2333/56 , G01N2800/042 , G01N2800/24
摘要： The present invention relates generally to the generation and characterization of neutralizing anti-IFN-α monoclonal antibodies with broad reactivity against various IFN-α subtypes. The invention further relates to the use of such anti-IFN-α antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-α, in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
摘要翻译： 本发明一般涉及对各种IFN-α亚型具有广泛反应性的中和抗IFN-α单克隆抗体的产生和表征。 本发明还涉及这种抗-IFN-α抗体在诊断和治疗与增加的IFN-α表达有关的病症中的用途，特别是自身免疫疾病如胰岛素依赖性糖尿病（IDDM）和系统性红斑狼疮 （SLE）。
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公开(公告)号：US20120244148A1
公开(公告)日：2012-09-27
申请号：US13476878
申请日：2012-05-21
IPC分类号： A61K39/395 , C12N15/13 , A61P37/06 , C12N15/63 , C12P21/02 , C12N1/21 , A61P3/10 , C12N5/18 , C12N5/10 , C12N5/28 , C12N5/22 , C12N1/19 , C07K16/24 , G01N33/53
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/564 , G01N33/6866 , G01N2333/56 , G01N2800/042 , G01N2800/24
摘要： The present invention relates generally to the generation and characterization of neutralizing anti-IFN-α monoclonal antibodies with broad reactivity against various IFN-α subtypes. The invention further relates to the use of such anti-IFN-α antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-α, in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
摘要翻译： 本发明一般涉及对各种IFN-α亚型具有广泛反应性的中和抗IFN-α单克隆抗体的产生和表征。 本发明还涉及这种抗-IFN-α抗体在诊断和治疗与增加的IFN-α表达有关的病症中的用途，特别是自身免疫疾病如胰岛素依赖性糖尿病（IDDM）和系统性红斑狼疮 （SLE）。
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公开(公告)号：US07910707B2
公开(公告)日：2011-03-22
申请号：US11423588
申请日：2006-06-12
IPC分类号： C07K16/00
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/564 , G01N33/6866 , G01N2333/56 , G01N2800/042 , G01N2800/24
摘要： The present invention relates generally to the generation and characterization of neutralizing anti-IFN-α monoclonal antibodies with broad reactivity against various IFN-α subtypes. The invention further relates to the use of such anti-IFN-α antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-α, in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
摘要翻译： 本发明一般涉及对各种IFN-α亚型具有广泛反应性的中和抗IFN-α单克隆抗体的产生和表征。 本发明还涉及这种抗-IFN-α抗体在诊断和治疗与增加的IFN-α表达有关的病症中的用途，特别是自身免疫疾病如胰岛素依赖性糖尿病（IDDM）和系统性红斑狼疮 （SLE）。
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公开(公告)号：US07582445B2
公开(公告)日：2009-09-01
申请号：US11373527
申请日：2006-03-10
IPC分类号： C12N15/00
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/564 , G01N33/6866 , G01N2333/56 , G01N2800/042 , G01N2800/24
摘要： Compositions of matter encoding or useful for expressing anti-interferon alpha antibodies are provided. Methods of using such compositions of matter for producing anti-interferon alpha antibodies are also provided.
摘要翻译： 提供了编码或用于表达抗干扰素α抗体的组合物。 还提供了使用这种物质组合物来生产抗干扰素α抗体的方法。
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公开(公告)号：US08513389B2
公开(公告)日：2013-08-20
申请号：US13530854
申请日：2012-06-22
IPC分类号： C07K16/24
CPC分类号： A61K45/06 , A61K2039/505 , C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Engineered antibodies to human IL-23p19 are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders.
摘要翻译： 提供了针对人IL-23p19的工程抗体，以及其用途，例如， 治疗炎症，自身免疫和增殖性疾病。
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公开(公告)号：US08512705B2
公开(公告)日：2013-08-20
申请号：US13532139
申请日：2012-06-25
IPC分类号： A61K39/395
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/244 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention relates to binding compounds that specifically bind to human TSLP, as well as uses thereof, e.g., in the treatment of inflammatory disorders.
摘要翻译： 本发明涉及特异性结合人TSLP的结合化合物，以及其用途，例如用于治疗炎症性疾病。
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