公开(公告)号：US20120078602A1

公开(公告)日：2012-03-29

申请号：US13246111

申请日：2011-09-27

申请人： Marcus Pfister ,  Thomas Redel

发明人： Marcus Pfister ,  Thomas Redel

IPC分类号： G06G7/60

CPC分类号： A61B6/504 ,  A61B6/4233 ,  A61B6/4441 ,  A61B6/4458 ,  A61B6/507 ,  A61B6/5235 ,  A61B2034/105 ,  G16H50/50

摘要： A method for predicting aneurysm growth based on CFD simulations derived from at least two angiography recordings is proposed. A first 3-D recording of the aneurysm is recorded at a first time and a first vascular geometry is determined for simulating a first CFD simulation. A second 3-D recording is recorded at a second time and a second vascular geometry is determined for simulating a second CFD simulation. The two 3-D recordings are registered and a local growth rate is determined from the two 3-D recordings. The local growth rate is correlated between the two vascular geometries with hemodynamically derived parameters from the first CFD simulation. A future vascular geometry and/or a future local growth rate is predicted based on the correlation parameters, the hemodynamic parameters from the second CFD simulation and the second vascular geometry.

摘要翻译： 提出了一种基于来自至少两个血管造影记录的CFD模拟预测动脉瘤生长的方法。 第一次记录动脉瘤的第一个3-D记录，并且确定用于模拟第一个CFD模拟的第一血管几何形状。 在第二时间记录第二个3-D记录，并且确定用于模拟第二个CFD模拟的第二血管几何形状。 两个3-D记录被记录，并且从两个3-D记录确定局部增长率。 本地生长速率与来自第一CFD模拟的血液动力学派生参数的两个血管几何形状相关。 基于相关参数，来自第二CFD模拟的血液动力学参数和第二血管几何，预测未来血管几何形状和/或未来局部生长速率。

公开(公告)号：US20120041301A1

公开(公告)日：2012-02-16

申请号：US13208451

申请日：2011-08-12

申请人： Thomas Redel

发明人： Thomas Redel

IPC分类号： A61B6/00 ,  G06G7/60 ,  G06G7/57

CPC分类号： A61B6/4441 ,  A61B6/4458 ,  A61B6/481 ,  A61B6/504 ,  A61B6/507

摘要： A method for simulating a blood flow in a vascular segment of a patient is proposed. A 3D image dataset of an examination region is recorded by a radiographic diagnostic device for generating a 3D vascular model. Contrast agent propagation in the examination region is captured by a dynamic 2D angiography method for generating a real 2D angiography recording. A CFD simulation of the blood flow is performed in the 3D vascular model based on a blood flow parameter for generating a virtual 2D angiography recording. A degree of correspondence between the real and the virtual 2D angiography recordings is determined from identical angulation and adjusted recording geometry of the patient and compared with predefinable tolerance values. The CFD simulation is iteratively optimized while changing the blood flow parameter as a function of the comparison. The degree of correspondence is outputted when the optimum CFD simulation is achieved.

摘要翻译： 提出了一种模拟患者血管段血流的方法。 检查区域的3D图像数据集由用于产生3D血管模型的射线照相诊断装置记录。 通过用于产生真实2D血管造影记录的动态2D血管造影方法捕获检查区域中的造影剂传播。 基于用于产生虚拟2D血管造影记录的血流参数，在3D血管模型中进行血流量的CFD模拟。 实际和虚拟2D血管造影记录之间的对应程度由患者的相同角度和调整的记录几何形状确定，并与预先确定的容差值进行比较。 CFD模拟被迭代优化，同时根据比较改变血流参数。 当达到最佳CFD模拟时，输出对应度。

公开(公告)号：US08090176B2

公开(公告)日：2012-01-03

申请号：US12157356

申请日：2008-06-10

申请人： Klaus Kinnstaetter ,  Thomas Redel

发明人： Klaus Kinnstaetter ,  Thomas Redel

IPC分类号： G06K9/00

CPC分类号： G06T7/0012 ,  A61B6/507 ,  G06T2207/10121 ,  G06T2207/30104

摘要： A computer receives a temporal sequence of x-ray images of an examination region of an examination object. The examination region includes a blood vessel system and tissue supplied with blood. A detection time is assigned in each instance to the x-ray images. The x-ray images correspond locally with one another in terms of pixels and each display a distribution of a contrast agent in the examination region at the respective detection time. The computer determines the temporal course of the temporal derivation of the data values and/or of the average value of the data values of the pixels located in the evaluation region for at least one evaluation region which is standard for all x-ray images. It assigns a type to the evaluation region as a function hereof.

摘要翻译： 计算机接收检查对象的检查区域的X射线图像的时间序列。 检查区域包括供血的血管系统和组织。 在每种情况下将检测时间分配给x射线图像。 X射线图像在像素上彼此局部对应，并且在相应的检测时间显示检查区域中造影剂的分布。 计算机确定对于对于所有X射线图像是标准的至少一个评估区域，数据值的时间推导的时间导航和/或位于评估区域中的像素的数据值的平均值的时间过程。 它作为一个函数为评估区域分配一个类型。

公开(公告)号：US07860288B2

公开(公告)日：2010-12-28

申请号：US11809276

申请日：2007-05-31

申请人： Philipp Bernhardt ,  Estelle Camus ,  Martin Hoheisel ,  Thomas Redel

发明人： Philipp Bernhardt ,  Estelle Camus ,  Martin Hoheisel ,  Thomas Redel

IPC分类号： G06K9/00 ,  H05G1/70 ,  H05G1/10 ,  A61B5/05 ,  A61B5/02

CPC分类号： G01N23/04 ,  A61B6/4241 ,  A61B6/481 ,  A61B6/482 ,  A61B6/504 ,  A61B6/507 ,  G06T2207/30101

摘要： A sequence of groups of projection images shows an object under examination comprising a vascular system and its environment. A computer determines a 2-dimensional evaluation image having a plurality of pixels based on combination images determined from the projection images of a group. The combination images have a plurality of pixels with pixel values. The sequence of the combination images shows the time characteristic of the distribution of a contrast medium in the object. The pixels of the evaluation image correspond to those of the projection images. The computer assigns each pixel, at least in a part area of the evaluation image, a type that is characteristic of whether the respective pixel corresponds to a vessel of the vascular system, a perfusion area or a background. It performs the assignment of the type on the basis of the time characteristic of the pixel values of the combination images.

摘要翻译： 一组投影图像的一系列显示一个被检查的物体，包括血管系统及其环境。 基于从组的投影图像确定的组合图像，计算机确定具有多个像素的二维评估图像。 组合图像具有多个具有像素值的像素。 组合图像的顺序示出了对象中造影剂的分布的时间特性。 评估图像的像素对应于投影图像的像素。 计算机至少在评估图像的一部分区域中分配每个像素，其特征在于各个像素是否对应于血管系统的血管，灌注区域或背景。 它根据组合图像的像素值的时间特性来执行类型的分配。

公开(公告)号：US07729746B2

公开(公告)日：2010-06-01

申请号：US11266886

申请日：2005-11-04

申请人： Thomas Redel ,  Estelle Camus ,  Oliver Meissner

发明人： Thomas Redel ,  Estelle Camus ,  Oliver Meissner

IPC分类号： A61B5/05

CPC分类号： A61B6/481 ,  A61B5/0066 ,  A61B5/7285 ,  A61B6/466 ,  A61B6/503 ,  A61B6/504 ,  A61B6/5247 ,  A61B6/541 ,  A61B8/0891 ,  A61B8/12 ,  A61B8/4416

摘要： A method and appertaining system permit a co-registration between points in a three-dimensional model of a vessel and vascular images obtained by an imaging catheter within the vessel at the respective points. The three-dimensional model is created by utilizing information from at least two external two-dimensional images produced by, e.g., one or more x-ray devices. The three-dimensional model is displayed on an analysis workstation, and a user may view the vascular images at particular points by selecting the appertaining points on the three-dimensional model.

摘要翻译： 一种方法和附属系统允许在血管的三维模型中的点之间的共同配准和在血管内的成像导管在各个点处获得的血管图像。 通过利用由例如一个或多个x射线装置产生的至少两个外部二维图像的信息来创建三维模型。 三维模型显示在分析工作站上，用户可以通过选择三维模型上的点来查看特定点的血管图像。

公开(公告)号：US07729525B2

公开(公告)日：2010-06-01

申请号：US11505552

申请日：2006-08-17

申请人： Estelle Camus ,  Thomas Redel

发明人： Estelle Camus ,  Thomas Redel

IPC分类号： G06K9/00

CPC分类号： A61B6/507 ,  A61B6/481 ,  A61B6/504 ,  G06K9/38 ,  G06K2209/05 ,  G06T7/0016 ,  G06T7/215 ,  G06T2207/10121 ,  G06T2207/30048 ,  G06T2207/30104

摘要： 2-D projection images show the temporal course of the distribution of a contrast medium in an examination object containing a vascular system and the surroundings thereof. Each projection image has pixels with pixel values defined by the same areas of the examination object. A computer determines a 2-D evaluation image having pixels corresponding to those of the projection images and assigns each pixel in a sub-area to one of three types, vessel, perfused part of the surroundings or non-perfused part of the surroundings. The computer assigns an extent of a perfusion in the pixels of the evaluation image assigned the type of perfused part of the surroundings to the respective pixel. The type and extend are determined from the temporal course of the pixel values of the pixels of the projection image which is in a two-dimensional evaluation core defined by a respective pixel of the evaluation image.

摘要翻译： 2-D投影图像示出了在包含血管系统的检查对象及其周围环境中造影剂的分布的时间过程。 每个投影图像具有由检查对象的相同区域定义的像素值的像素。 计算机确定具有与投影图像的像素相对应的像素的2-D评估图像，并将子区域中的每个像素分配给三种类型中的一种，周围的血管，灌注部分或周围环境的非灌注部分。 计算机将分配了周围环境类型的评估图像的像素中的灌注程度分配给各个像素。 根据由评估图像的各个像素定义的二维评估核心中的投影图像的像素的像素值的时间过程来确定类型和扩展。

公开(公告)号：US20090180676A1

公开(公告)日：2009-07-16

申请号：US12319517

申请日：2009-01-08

申请人： Marcus Pfister ,  Thomas Redel

发明人： Marcus Pfister ,  Thomas Redel

IPC分类号： G06K9/00

CPC分类号： A61B6/504 ,  A61B6/4441 ,  A61B6/481 ,  A61B6/5229 ,  A61B6/5235 ,  A61B6/5241

摘要： Method for creating image recordings of blood vessel system of a patient, comprising: after administering contrast agent an image recording is created in a first image recording region of a first position of a detector, the diffusion of the contrast agent is observed to determine a current diffusion position; the position of the detector is changed to a second position as a function of the current diffusion position; an image recording of a second image recording region of the second position of the detector is created; and a part of an image recording in the first position extending in the region between the current diffusion position and the end of the first image recording region and recorded without contrast agent is used as a mask to evaluate a locationally correlated part, recorded with contrast agent, of the image recording in the second position for digital subtraction angiography.

摘要翻译： 一种用于创建患者血管系统图像记录的方法，包括：在给予造影剂之后，在检测器的第一位置的第一图像记录区域中产生图像记录，观察造影剂的扩散以确定电流 扩散位置; 检测器的位置作为当前扩散位置的函数被改变到第二位置; 创建检测器的第二位置的第二图像记录区域的图像记录; 并且使用在当前扩散位置和第一图像记录区域的末端之间的区域中延伸并且没有造影剂记录的第一位置的图像记录的一部分作为掩模来评估用造影剂记录的位置相关部分 ，用于数字减影血管造影术的第二位置的图像记录。

公开(公告)号：US07539531B2

公开(公告)日：2009-05-26

申请号：US11357539

申请日：2006-02-17

申请人： Estelle Camus ,  Martin Kleen ,  Thomas Redel

发明人： Estelle Camus ,  Martin Kleen ,  Thomas Redel

IPC分类号： A61B6/00

CPC分类号： A61M25/003 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B5/6853 ,  A61M25/1011 ,  A61M2025/0036 ,  A61M2025/004 ,  A61M2025/1052

摘要： Catheter device for insertion into a vessel of a human or animal body, comprising a guide catheter and, incorporated in same, an OCT catheter with an OCT imaging device, the guide catheter having a balloon inflatable via a supply line for occluding the vessel, as well as a device for delivering a liquid or gas to the vascular region to be recorded by means of the OCT imaging device, in particular the vascular region located distally to the balloon, wherein there is provided on the guide catheter a second inflatable balloon spaced apart from the first balloon for occluding the vessel, wherein the section of the guide catheter between the two balloons is transparent, at least in sections, to the OCT radiation emittable by the OCT imaging device disposed inside the guide catheter.

摘要翻译： 用于插入到人体或动物体的容器中的导管装置，包括导向导管，并且包括具有OCT成像装置的OCT导管，所述引导导管具有可通过用于封闭血管的供应管线充气的气囊，如 以及用于将血液或气体输送到血管区域以通过OCT成像装置记录的装置，特别是位于远端到气囊的血管区域的装置，其中在引导导管上设置有间隔开的第二可充气气囊 从用于封闭血管的第一气囊，其中在两个气囊之间的导向导管的部分至少部分地透明到由设置在引导导管内的OCT成像装置发射的OCT辐射。

公开(公告)号：US20090003521A1

公开(公告)日：2009-01-01

申请号：US11824334

申请日：2007-06-28

申请人： Estelle Camus ,  Oliver Meissner ,  Martin Ostermeier ,  Thomas Redel

发明人： Estelle Camus ,  Oliver Meissner ,  Martin Ostermeier ,  Thomas Redel

IPC分类号： A61B6/03

CPC分类号： A61B6/032 ,  A61B6/481 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5235

摘要： A method of optimized diagnosis and treatment of suspected myocardial infarctions is described. The patient having possible coronary artery disease is transferred to a treatment room with an imaging modality suitable for obtaining computed tomographic (CT)-like images. Such images are obtained as radiographic image data, with or without contrast agent, and used in the medical diagnosis. If minimally invasive therapy such as percutaneous transluminal coronal angioplasty (PTCA) is indicated, the patient is prepared for the procedure in the same room, and the procedure performed, where the imaging modality is used to obtain fluoroscopic images to guide the PTCA procedure, or to assess the results of the procedure. The imaging modality may be mounted to a first positioning robot, and a second robot may facilitate the positioning or movement of the patient.

摘要翻译： 描述了可疑心肌梗死的优化诊断和治疗方法。 具有可能的冠状动脉疾病的患者被转移到具有适于获得计算机断层摄影（CT）样图像的成像模式的治疗室。 这样的图像作为放射照相图像数据获得，具有或不具有造影剂，并且用于医学诊断。 如果显示微创治疗如经皮腔内冠状动脉血管成形术（PTCA），则患者准备在同一房间中的手术，并且执行该过程，其中使用成像模式获得荧光镜图像以引导PTCA程序，或 评估程序的结果。 成像模式可以安装到第一定位机器人，并且第二机器人可以促进患者的定位或移动。

公开(公告)号：US20080095423A1

公开(公告)日：2008-04-24

申请号：US11973246

申请日：2007-10-05

申请人： Thomas Redel ,  Estelle Camus

发明人： Thomas Redel ,  Estelle Camus

IPC分类号： G06K9/00

CPC分类号： A61B6/504 ,  A61B6/481 ,  A61B6/507 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/38 ,  G06T2207/10072 ,  G06T2207/10116 ,  G06T2207/30104

摘要： Data of an examination object comprises a volume-data record and a plurality of two-dimensional projection images. The volume-data record includes voxels where each voxel is assigned to a location in three-dimensional space. Each projection image includes pixels where each pixel is assigned to a location in a two-dimensional-projection plane and has a value. Each pixel is assigned a projection volume, this being specified in that it is mapped by the radioscopy onto the pixel to which it is assigned. A sub-volume of the volume-data record is selected. The projection images are registered in relation to the volume-data record. A functional parameter of the examination object is specified for the pixels of the projection images, depending on their values. For each pixel, when specifying the functional parameter, consideration is given to the locations and/or the number of those voxels which are positioned both within the sub-volume and within the projection volume.

摘要翻译： 检查对象的数据包括体数据记录和多个二维投影图像。 体数据记录包括体素，其中每个体素被分配到三维空间中的位置。 每个投影图像包括其中每个像素被分配给二维投影平面中的位置并具有值的像素。 每个像素被分配一个投影体积，这被指定为通过放射镜被映射到其被分配到的像素上。 选择卷数据记录的子卷。 相对于卷数据记录登记投影图像。 根据投影图像的像素值，为检查对象的像素指定功能参数。 对于每个像素，当指定功能参数时，考虑定位在子体积内和投影体积内的那些体素的位置和/或数量。