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    Bactericidal formulations for use in veterinary medicine
    78.
    发明授权
    Bactericidal formulations for use in veterinary medicine 失效
    用于兽药的杀菌剂

    公开(公告)号：US5145853A

    公开(公告)日：1992-09-08

    申请号：US635817

    申请日：1991-01-02

    申请人： Karl G. Metzger ,  Hans-Joachim Zeiler ,  Martin Scheer ,  Herbert Voege ,  Klaus Grohe

    发明人： Karl G. Metzger ,  Hans-Joachim Zeiler ,  Martin Scheer ,  Herbert Voege ,  Klaus Grohe

    IPC分类号： C07D215/56 ,  A61K20060101 ,  A61K31/44 ,  A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61P31/00 ,  A61P31/04

    CPC分类号： A61K31/47 ,  A61K31/44 ,  A61K31/535

    摘要： A method of treating livestock infected with, or protecting livestock against infection from, bacteria which comprises administering to such livestock an antibacterially effective amount of a quinolonecarboxylic acid or derivative of the formula ##STR1## in which A represents nitrogen or .dbd.C--R.sup.4,R.sup.4 represents hydrogen, fluorine, chlorine, nitro or methyl,B represents ##STR2## and B also represents ##STR3## when R.sup.1 does not denote cyclopropyl, and R.sup.5 represents hydrogen, a branched or unbranched alkyl group which has 1 to 4 carbon atoms and which can optionally be substituted by a hydroxyl or methoxy group,R.sup.6 represents hydrogen, methyl or phenyl,R.sup.7 represents hydrogen or methyl,R.sup.8 represents amino, alkyl- or dialkylamino having 1 or 2 carbon atoms in the alkyl group, aminomethyl, alkyl- or dialkylaminomethyl having 1 or 2 carbon atoms in the alkyl group,R.sup.1 represents an alkyl radical having 1 to 3 carbon atoms, cyclopropyl, 2-fluoroethyl vinyl, methoxy, 4-fluorophenyl or methylamino,R.sup.2 represents hydrogen, alkyl having 1 to 6 carbon atoms, and cyclohexyl, benzyl, 2-oxopropyl, phenacyl and ethoxycarbonylmethyl,R.sup.3 represents hydrogen, methyl or ethyl, Z represents oxygen, nitrogen which is substituted by methyl or phenyl, and .dbd.CH.sub.2 --,or a pharmaceutically utilizable salt thereof.

    摘要翻译： 一种治疗感染或保护家畜免受细菌感染的牲畜的方法，其包括向所述家畜施用抗菌有效量的喹诺酮羧酸或其中A表示氮或= C的式“IMAGE”或“IMAGE”的衍生物 -R4，R4表示氢，氟，氯，硝基或甲基，当R1不表示环丙基时，B表示“IMAGE”，并且B也表示“IMAGE”，R5表示氢，支链或非支链烷基，其具有1至4个 碳原子，并且其可以任选被羟基或甲氧基取代，R6表示氢，甲基或苯基，R7表示氢或甲基，R8表示氨基，烷基中具有1或2个碳原子的烷基或二烷基氨基，氨基甲基， 烷基中具有1或2个碳原子的烷基 - 或二烷基氨基甲基，R 1表示具有1至3个碳原子的烷基，环丙基，2-氟乙基乙烯基，甲氧基，4-氟苯基或我 二氨基，R2代表氢，具有1-6个碳原子的烷基，环己基，苄基，2-氧代丙基，苯甲酰甲基和乙氧羰基甲基，R3代表氢，甲基或乙基，Z代表氧，被甲基或苯基取代的氮， CH2-或其药学上可用的盐。