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168 条记录 (耗时 0.086 秒)

    2-(1H-indazol-3-yl)-1H-imidazo[4,5-C]pyridine and therapeutic uses thereof
    75.
    发明授权
    2-(1H-indazol-3-yl)-1H-imidazo[4,5-C]pyridine and therapeutic uses thereof 有权
    2-（1H-吲唑-3-基）-1H-咪唑并[4,5-C]吡啶及其治疗用途

    公开(公告)号：US09475807B2

    公开(公告)日：2016-10-25

    申请号：US14847259

    申请日：2015-09-08

    申请人： Samumed, LLC

    发明人： Sunil Kumar KC ,  David Mark Wallace ,  Jianguo Cao ,  Chandramouli Chiruta ,  John Hood

    IPC分类号： C07D401/14 ,  A61K31/437 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

    摘要翻译： 公开了用于治疗各种疾病和病症的吲唑化合物。 更具体地，本发明涉及吲唑化合物或其类似物在治疗以Wnt途径信号传导（例如癌症，异常细胞增殖，血管发生，纤维化病症，骨或软骨疾病和 骨关节炎），由Wnt途径信号传导介导的细胞事件的调节，以及由于Wnt途径的突变或失调引起的遗传疾病和神经病症/疾病/疾病和/或Wnt信号成分中的一种或多种。 还提供了治疗Wnt相关疾病状态的方法。

    Indazole inhibitors of the WNT signal pathway and therapeutic uses thereof
    77.
    发明授权
    Indazole inhibitors of the WNT signal pathway and therapeutic uses thereof 有权
    WNT信号通路的吲唑抑制剂及其治疗用途

    公开(公告)号：US09199991B2

    公开(公告)日：2015-12-01

    申请号：US14621195

    申请日：2015-02-12

    申请人： Samumed, LLC

    发明人： John Hood ,  David Mark Wallace ,  Sunil Kumar KC

    IPC分类号： A61K31/437 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07B2200/13

    摘要： Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

    摘要翻译： 公开了用于治疗各种疾病和病症的吲唑化合物。 更具体地，本发明涉及吲唑化合物或其类似物在治疗以Wnt途径信号传导（例如癌症，异常细胞增殖，血管发生，阿尔茨海默病，肺部疾病和骨关节炎）的活化为特征的疾病中的用途， 由Wnt途径信号传导介导的细胞事件的调节，以及由于Wnt途径的突变或失调和/或一种或多种Wnt信号成分导致的遗传疾病和神经病症/疾病/疾病。 还提供了治疗Wnt相关疾病状态的方法。

    Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof
    79.
    发明授权
    Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof 有权
    Wnt信号通路的吲唑抑制剂及其治疗用途

    公开(公告)号：US08987298B2

    公开(公告)日：2015-03-24

    申请号：US14178749

    申请日：2014-02-12

    申请人： Samumed, LLC

    发明人： John Hood ,  David Mark Wallace ,  Sunil Kumar KC

    IPC分类号： C07D471/04 ,  A61K31/505 ,  A61K31/44

    CPC分类号： C07D471/04 ,  C07B2200/13

    摘要： Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

    摘要翻译： 公开了用于治疗各种疾病和病症的吲唑化合物。 更具体地，本发明涉及吲唑化合物或其类似物在治疗以Wnt途径信号传导（例如癌症，异常细胞增殖，血管发生，阿尔茨海默病，肺部疾病和骨关节炎）的活化为特征的疾病中的用途， 由Wnt途径信号传导介导的细胞事件的调节，以及由于Wnt途径的突变或失调和/或一种或多种Wnt信号成分导致的遗传疾病和神经病症/疾病/疾病。 还提供了治疗Wnt相关疾病状态的方法。