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公开(公告)号：US07718628B2
公开(公告)日：2010-05-18
申请号：US11618167
申请日：2006-12-29
申请人： Kenneth W. Dobie , Erich Koller
发明人： Kenneth W. Dobie , Erich Koller
CPC分类号： C12N15/113 , A01K2267/0331 , A61K31/711 , A61K31/713 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding kinesin-like 1. Methods of using these compounds for modulation of kinesin-like 1 expression and for treatment of diseases associated with expression of kinesin-like 1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节驱动蛋白样1的表达。组合物包含靶向编码驱动蛋白样物质的核酸的反义化合物，特别是反义寡核苷酸1.使用这些化合物调节驱动蛋白样1 提供表达和用于治疗与驱动蛋白样1的表达相关的疾病。
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公开(公告)号：US20090286849A1
公开(公告)日：2009-11-19
申请号：US12342025
申请日：2008-12-22
IPC分类号： A61K31/711 , C07H21/00 , C12Q1/68 , G01N33/68 , A61P17/06
CPC分类号： C07H21/04 , A61K38/00 , C07H21/00 , C07H21/02 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , Y10T436/143333 , C12N2310/3525
摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory condition.
摘要翻译： 本发明提供调节生长因子基因表达的组合物和方法。 特别地，本发明涉及化合物，特别是寡核苷酸化合物，其在优选的实施方案中与编码胰岛素样生长因子I受体（IGF-1受体或IGF-1R），特别是人IGF-1R的核酸分子杂交。 这些化合物在本文中示例以调节与治疗增殖性和炎症性皮肤病症和癌症有关的增殖。 然而，应当理解，该化合物可用于涉及IGF-1R的任何其它病症，包括炎症状况。
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公开(公告)号：US07563885B1
公开(公告)日：2009-07-21
申请号：US11135255
申请日：2005-05-23
IPC分类号： C07H21/04
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of Tudor-SN. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Tudor-SN. Methods of using these compounds for modulation of Tudor-SN expression and for diagnosis and treatment of diseases and conditions associated with expression of Tudor-SN are provided.
摘要翻译： 提供化合物，组合物和方法用于调节Tudor-SN的表达。 组合物包含靶向编码Tudor-SN的核酸的寡核苷酸。 提供了使用这些化合物调节Tudor-SN表达和诊断和治疗与Tudor-SN表达相关的疾病和病症的方法。
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公开(公告)号：US07507808B2
公开(公告)日：2009-03-24
申请号：US10319915
申请日：2002-12-12
申请人： Kenneth W. Dobie
发明人： Kenneth W. Dobie
CPC分类号： C07H21/00 , C07H21/04 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/01003 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lipase expression and for diagnosis and treatment of disease associated with expression of endothelial lipase are provided.
摘要翻译： 提供化合物，组合物和方法用于调节内皮脂肪酶的表达。 组合物包含靶向编码内皮脂肪酶的核酸的寡核苷酸。 提供了使用这些化合物调节内皮脂肪酶表达和用于诊断和治疗与内皮脂肪酶表达相关的疾病的方法。
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公开(公告)号：US07468356B2
公开(公告)日：2008-12-23
申请号：US10545354
申请日：2004-02-11
CPC分类号： C07H21/04 , A61K38/00 , C07H21/00 , C07H21/02 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , Y10T436/143333 , C12N2310/3525
摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory conditions.
摘要翻译： 本发明提供调节生长因子基因表达的组合物和方法。 特别地，本发明涉及化合物，特别是寡核苷酸化合物，其在优选的实施方案中与编码胰岛素样生长因子I受体（IGF-1受体或IGF-1R），特别是人IGF-1R的核酸分子杂交。 这些化合物在本文中示例以调节与治疗增殖性和炎症性皮肤病症和癌症有关的增殖。 然而，应当理解，所述化合物可用于涉及IGF-1R的任何其它病症，包括炎性病症。
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公开(公告)号：US08513400B2
公开(公告)日：2013-08-20
申请号：US12642534
申请日：2009-12-18
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C07F9/65586 , A61K38/00 , C07F9/65616 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
摘要翻译： 提供化合物，组合物和方法用于调节HIF1α和/或HIF2α的表达。 组合物包含针对编码HIF1α和HIF2α的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1α和/或HIF2α表达以及用于诊断和治疗与HIF1α和/或HIF2α的表达相关的疾病的方法。
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公开(公告)号：US08217017B2
公开(公告)日：2012-07-10
申请号：US12342025
申请日：2008-12-22
申请人： Kenneth W. Dobie
发明人： Kenneth W. Dobie
CPC分类号： C07H21/04 , A61K38/00 , C07H21/00 , C07H21/02 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , Y10T436/143333 , C12N2310/3525
摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory condition.
摘要翻译： 本发明提供调节生长因子基因表达的组合物和方法。 特别地，本发明涉及化合物，特别是寡核苷酸化合物，其在优选的实施方案中与编码胰岛素样生长因子I受体（IGF-1受体或IGF-1R），特别是人IGF-1R的核酸分子杂交。 这些化合物在本文中示例以调节与治疗增殖性和炎症性皮肤病症和癌症有关的增殖。 然而，应当理解，该化合物可用于涉及IGF-1R的任何其它病症，包括炎症状况。
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公开(公告)号：US20120165396A1
公开(公告)日：2012-06-28
申请号：US13330262
申请日：2011-12-19
申请人： Kenneth W. Dobie
发明人： Kenneth W. Dobie
IPC分类号： A61K31/713 , A61P43/00 , C12N5/071 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/14
摘要： Compounds, compositions and methods are provided for modulating the expression of exportin 5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding exportin 5. Methods of using these compounds for modulation of exportin 5 expression and for diagnosis and treatment of diseases and conditions associated with expression of exportin 5 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节出口5的表达。该组合物包含寡核苷酸，靶向编码出口的核酸。5.使用这些化合物调节出口表达和用于诊断和治疗与 提供exportin 5的表达。
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公开(公告)号：US20110190370A1
公开(公告)日：2011-08-04
申请号：US12642534
申请日：2009-12-18
IPC分类号： A61K31/7088 , C07H21/04 , A61P35/00 , C12N5/00
CPC分类号： C07F9/65586 , A61K38/00 , C07F9/65616 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
摘要翻译： 提供化合物，组合物和方法用于调节HIF1α和/或HIF2α的表达。 组合物包含针对编码HIF1α和HIF2α的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1α和/或HIF2α表达以及用于诊断和治疗与HIF1α和/或HIF2α的表达相关的疾病的方法。
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80.发明申请MODULATION OF GROWTH HORMONE RECEPTOR EXPRESSION AND INSULIN-LIKE GROWTH FACTOR EXPRESSION 有权生长激素受体表达和胰岛素样生长因子表达的调节公开(公告)号：US20110092572A1
公开(公告)日：2011-04-21
申请号：US12953105
申请日：2010-11-23
IPC分类号： A61K31/7088 , C07H21/02 , A61P3/10 , A61P5/00 , A61P19/02 , A61P35/00 , C12N5/071 , C12Q1/68 , G01N33/53
CPC分类号： C12N15/1138 , A61K47/554 , C12N2310/11 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/74 , G01N2333/71 , Y10T436/143333
摘要： Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
摘要翻译： 提供化合物，组合物和方法用于调节生长激素受体和/或胰岛素样生长因子-I（IGF-I）的表达。 组合物包含针对编码生长激素受体的核酸的寡核苷酸。 提供了使用这些化合物调节生长激素受体表达和用于诊断和治疗与生长激素受体和/或胰岛素样生长因子-I表达相关的疾病的方法。 还提供诊断方法和试剂盒。
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