摘要:
This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要:
This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要:
The present invention relates to the use of sonic hedgehog antagonists in the prevention and treatment of cancer and other hyperproliferative diseases or disorders. Methods for identifying such antagonists are also provided.
摘要:
An orbital rotary blade sharpener for sharpening rotary cutter blades and other rotary blades includes a bottom blade holding portion having a center and a perimeter edge, a top blade holding portion rotatably connectable to said bottom blade holding portion, having a perimeter and a center, a central shaft portion extending from said bottom blade holding portion through said top blade holding portion over which a rotary blade can be fitted, a radial shaft portion extending through said top blade holding portion positioned between the perimeter and the center of the top blade holding portion, and grinding portion connected to said radial shaft portion, and within said top blade holding portion, positioned to be orbitally revolvable around said bottom blade holding portion center and contactable with a blade held between said top and bottom blade holding portions.
摘要:
A liner holds objects in place within a form for a poured wall. The liner includes a backing sheet and a plurality of foam bed joints arranged in a substantially parallel fashion along a length dimension. A plurality of separate foam head joints are attached along a height dimension, wherein opposing ends of the foam head joints engage adjacent bed joints to define a plurality of regions on the backing sheet for receiving the objects to be cast in the poured wall. Each foam joint has a rounded cross section to form a curved grout line between the objects cast in the poured wall. The foam joints include an outer protective skin to prevent the poured wall material from bonding with the foam cells. A method of forming the liner includes aligning the separate foam bed joints and head joints in a grid and then pressing an adhesive-backed paper sheet against the foam joints.
摘要:
The present invention provides methods and compositions for screening a subject for Parkinson disease, for increased risk of developing Parkinson disease and/or for an earlier or later age of developing Parkinson disease, comprising detecting the presence of a genetic marker associated with Parkinson disease.
摘要:
A method for processing scanned code data, including a plurality of strings, to determine whether the scanned code data is part of a valid code begins by examining a first string of a first scanned code data. A cluster is opened with the first string if the first string contains a start pattern. At least one valid middle portion of the first string is identified and a transition position count associated with the at least one valid middle portion is stored. A second scanned code data is searched for a second string matching at least part of the first string in the cluster. If a match is found, then the second string is added to the end of the cluster. The cluster is closed upon detection of a stop pattern and is then decoded.
摘要:
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.