-
公开(公告)号：US20050192269A1
公开(公告)日：2005-09-01
申请号：US11002951
申请日：2004-12-03
Applicant: Richard Thompson , Stephen Wilkie , Douglas Stack , Eldon Vanmeter , Qing Shi , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , Steven Henry , Stacey McDaniel , Russell Stucky , Warren Porter
Inventor： Richard Thompson , Stephen Wilkie , Douglas Stack , Eldon Vanmeter , Qing Shi , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , Steven Henry , Stacey McDaniel , Russell Stucky , Warren Porter
IPC: A61K31/445 , A61K31/4706 , A61K31/501 , A61K31/55 , A61K38/00 , C07D401/12 , C07D403/12 , C07K5/097
CPC classification number: C07D401/12 , A61K38/00 , C07D403/12 , C07K5/0821 , C07K5/0823
Abstract: Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
-
2.发明申请Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds 审中-公开环烷基，内酰胺，内酯和相关化合物，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法公开(公告)号：US20050182046A1
公开(公告)日：2005-08-18
申请号：US10777247
申请日：2004-02-13
Applicant: Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
Inventor： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
IPC: A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/55 , A61K38/04 , A61K38/05 , A61P25/28 , C07D223/18 , C07D471/04 , C07D471/06 , C07D471/08
CPC classification number: C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
Abstract: Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Abstract translation: 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
-
公开(公告)号：US20060079499A1
公开(公告)日：2006-04-13
申请号：US11001608
申请日：2004-12-02
Applicant: Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
Inventor： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
IPC: A61K31/55 , A61K31/445
CPC classification number: C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
Abstract: Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
-
公开(公告)号：US20050272666A1
公开(公告)日：2005-12-08
申请号：US11001610
申请日：2004-12-02
Applicant: Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , Jeffrey Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
Inventor： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , Jeffrey Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
IPC: A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/55 , A61K38/04 , A61K38/05 , A61P25/28 , C07D223/18 , C07D471/04 , C07D471/06 , C07D471/08
CPC classification number: C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
Abstract: Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
-
5.发明申请Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds 审中-公开环烷基，内酰胺，内酯和相关化合物，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法公开(公告)号：US20050267150A1
公开(公告)日：2005-12-01
申请号：US11002921
申请日：2004-12-03
Applicant: Richard Thompson , Stephen Wilkie , Douglas Stack , Eldon Vanmeter , Qing Shi , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , Steven Henry , Stacey McDaniel , Russell Stucky , Warren Porter
Inventor： Richard Thompson , Stephen Wilkie , Douglas Stack , Eldon Vanmeter , Qing Shi , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , Steven Henry , Stacey McDaniel , Russell Stucky , Warren Porter
IPC: A61K31/445 , A61K31/4706 , A61K31/501 , A61K31/55 , A61K38/00 , C07D401/12 , C07D403/12 , C07K5/097
CPC classification number: C07D401/12 , A61K38/00 , C07D403/12 , C07K5/0821 , C07K5/0823
Abstract: Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Abstract translation: 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及预防性和治疗性地用这种药物组合物治疗阿尔茨海默病的方法。
-
Patent Agency Ranking
6.发明申请CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS 失效环己基，LACTAM，LACTONE和相关化合物，包含其的药物组合物，以及抑制β-淀粉样肽释放和/或通过使用这些化合物合成的方法公开(公告)号：US20050215541A1
公开(公告)日：2005-09-29
申请号：US10951992
申请日：2004-09-29
Applicant: Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Jeffrey Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
Inventor： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Jeffrey Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
IPC: A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/55 , A61K38/04 , A61K38/05 , A61P25/28 , C07D223/18 , C07D471/04 , C07D471/06 , C07D471/08
CPC classification number: C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
Abstract: Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Abstract translation: 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
-
7.发明申请Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds 有权环烷基，内酰胺，内酯和相关化合物，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法公开(公告)号：US20070203108A1
公开(公告)日：2007-08-30
申请号：US11433923
申请日：2006-05-12
Applicant: Eugene Thorsett , Michael Pleiss , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Bruce Dressman , James Droste , Steven Henry , Russell Stucky , Warren Porter
Inventor： Eugene Thorsett , Michael Pleiss , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Bruce Dressman , James Droste , Steven Henry , Russell Stucky , Warren Porter
IPC: A61K31/55 , A61K31/4704 , A61K31/473 , A61K31/445 , A61K31/395
CPC classification number: C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
Abstract: Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Abstract translation: 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
-
公开(公告)号：US20060217372A1
公开(公告)日：2006-09-28
申请号：US10526960
申请日：2003-09-17
Applicant: Maria-Jesus Blanco-Pillado , Mark Chappell , Marta De La Torre , Nuria Diaz Buezo , James Fritz , William Holloway , James Matt , Charles Mitch , Concepcion Pedregal-Tercero , Steven Wuimby , Miles Siegel , Dana Smith , Russell Stucky , Kumiko Takeuchi , Elizabeth Thomas , Chad Wolfe
Inventor： Maria-Jesus Blanco-Pillado , Mark Chappell , Marta De La Torre , Nuria Diaz Buezo , James Fritz , William Holloway , James Matt , Charles Mitch , Concepcion Pedregal-Tercero , Steven Wuimby , Miles Siegel , Dana Smith , Russell Stucky , Kumiko Takeuchi , Elizabeth Thomas , Chad Wolfe
IPC: A61K31/541 , A61K31/5377 , A61K31/501 , A61K31/506 , A61K31/497 , A61K31/496 , C07D417/02 , C07D413/02 , C07D403/02
CPC classification number: C07D213/643 , C07C235/46 , C07D213/38 , C07D213/64 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D217/04 , C07D237/24 , C07D239/34 , C07D241/24 , C07D307/14 , C07D307/52 , C07D333/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3′, E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.
Abstract translation: 式（I）的化合物，其中变量X 1至X 10，R 1至R 7， 包括R 3，E，V，Y，Z，A和B如上所述，或其药学上可接受的盐，溶剂合物，对映异构体，外消旋体，非对映体或其混合物，可用于治疗，预防 或改善肥胖及相关疾病。
-
公开(公告)号：US20050203080A1
公开(公告)日：2005-09-15
申请号：US10733877
申请日：2003-12-12
Applicant: Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
Inventor： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
IPC: A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/55 , A61K38/04 , A61K38/05 , A61P25/28 , C07D223/18 , C07D471/04 , C07D471/06 , C07D471/08
CPC classification number: C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
Abstract: Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
-
公开(公告)号：US20050192265A1
公开(公告)日：2005-09-01
申请号：US11002922
申请日：2004-12-03
Applicant: Richard Thompson , Stephen Wilkie , Douglas Stack , Eldon Vanmeter , Qing Shi , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , Steven Henry , Stacey McDaniel , Russell Stucky , Warren Porter
Inventor： Richard Thompson , Stephen Wilkie , Douglas Stack , Eldon Vanmeter , Qing Shi , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , Steven Henry , Stacey McDaniel , Russell Stucky , Warren Porter
IPC: A61K31/445 , A61K31/4706 , A61K31/473 , A61K31/55
CPC classification number: A61K31/445 , A61K31/4706 , A61K31/473 , A61K31/55
Abstract: Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
-
-
-
-
-
-
-
-
-
Search Results
11
records
(took 0.055 seconds)
