公开(公告)号：US07196193B2

公开(公告)日：2007-03-27

申请号：US10510008

申请日：2002-04-11

申请人： Shin Ikeda ,  Yasuhiro Takahashi

发明人： Shin Ikeda ,  Yasuhiro Takahashi

IPC分类号： C07D223/20 ,  C07D403/06

CPC分类号： C07D403/06 ,  C07D223/20

摘要： A production method of 6-aminomethyl-6,11-dihydro-5H-dibenz[b,e]azepin characterized in that said compound is produced via N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-o-hydroxymethylbenzamide which is prepared by reducing 2-(11H-dibenz[b,e]azepin-6-ylmethyl)-1H-isoindole-1,3(2H)-dione employing a metal hydride or a metal hydride complex in a water based alcohol, and N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-o-hydroxymethylbenzamide which is useful for the aforesaid production method.

摘要翻译： 6-氨基甲基-6,11-二氢-5H-二苯并[b，e]氮杂的制备方法，其特征在于所述化合物是通过N - [（6,11-二氢-5H-二苯并[b，e]氮杂 -6-基）甲基] - 羟基甲基苯甲酰胺，其是使用金属氢化物还原2-（11H-二苯并[b，e]氮杂-6-基甲基）-1H-异吲哚-1,3（2H） 或水基醇中的金属氢化物络合物和可用于上述制备方法的N - [（6,11-二氢-5H-二苯并[b，e]氮杂-6-基）甲基] - 羟基甲基苯甲酰胺 。

公开(公告)号：US20060030028A1

公开(公告)日：2006-02-09

申请号：US10312034

申请日：2002-06-14

申请人： Takahiro Nakaminami ,  Shin Ikeda ,  Toshihiko Yoshioka

发明人： Takahiro Nakaminami ,  Shin Ikeda ,  Toshihiko Yoshioka

IPC分类号： G01N33/53 ,  C12M1/34

CPC分类号： C12Q1/003 ,  C12Q1/004

摘要： A simple-structured biosensor is provided for measuring a substrate in a sample rapidly and highly precisely, without significant influence of a peptide included in the sample. A biosensor for measuring the substrate contained in a sample solution includes one or a plurality of insulating base plate(s) 1; a pair of electrodes including a working electrode 2 and a counter electrode 3 provided on the base plate 1; and a reagent 11 for measurement including a redox enzyme and an electron mediator. The sample solution contains a peptide, and the working electrode 2 includes a metal, and at least a part of a surface of the working electrode 2 is covered with a film 10 of an organic compound containing at least one sulfur atom.

摘要翻译： 提供了一种简单结构的生物传感器，用于在样品中包含的肽的显着影响下快速高度精确地测量样品中的底物。 用于测量包含在样品溶液中的基底的生物传感器包括一个或多个绝缘基板1; 包括设置在基板1上的工作电极2和对置电极3的一对电极; 和包含氧化还原酶和电子介体的测定用试剂11。 样品溶液含有肽，工作电极2包括金属，工作电极2的至少一部分表面被含有至少一个硫原子的有机化合物的膜10覆盖。

公开(公告)号：US06992223B2

公开(公告)日：2006-01-31

申请号：US10515974

申请日：2003-05-28

申请人： Shin Ikeda ,  Yasuhiro Takahashi

发明人： Shin Ikeda ,  Yasuhiro Takahashi

IPC分类号： C07C211/46

CPC分类号： C07C209/74 ,  C07C211/45

摘要： 2-benzylaniline can be manufactured in one-pot reaction at a substantially reduced cost by allowing 2-amino-5-halogenobenzophenone to react under a reductive condition.

摘要翻译： 2-苄基苯胺可以通过使2-氨基-5-卤代二苯甲酮在还原条件下反应，以大幅降低的成本在一锅反应中制备。

公开(公告)号：US20050145490A1

公开(公告)日：2005-07-07

申请号：US10954020

申请日：2004-09-28

申请人： Teppei Shinno ,  Shin Ikeda

发明人： Teppei Shinno ,  Shin Ikeda

IPC分类号： G01N33/483 ,  C12M1/34 ,  C12Q1/00 ,  C12Q1/26 ,  C12Q1/32 ,  G01N27/327 ,  G01N27/416 ,  G01N33/487 ,  G01N33/66 ,  G01N33/72 ,  C12M1/00 ,  C12N11/00 ,  C25B9/00 ,  C25B13/00 ,  G01N27/26

CPC分类号： C12Q1/001 ,  C12Q1/006 ,  G01N27/3274 ,  G01N33/66 ,  G01N33/721

摘要： A sensor for blood component analysis that can correct the effect of a hematocrit easily is provided. The sensor includes an analysis portion including a working electrode, a counter electrode, and a reagent portion. The reagent portion includes an oxidoreductase that reacts with the blood component and a mediator, and the blood component is measured by causing a redox reaction between the blood component and the oxidoreductase in the presence of the mediator and detecting a redox current generated by the redox reaction by the working electrode and the counter electrode. In this sensor, the reagent portion further includes a hemolyzing agent (e.g., sodium cholate) for hemolyzing an erythrocyte, and when detecting the redox current, the erythrocyte is hemolyzed with the hemolyzing agent so as to cause hemoglobin released to an outside of the erythrocyte to react with the mediator and a current generated by this reaction also is detected to correct an effect of a hematocrit.

摘要翻译： 提供了可以容易地校正血细胞比容的影响的用于血液成分分析的传感器。 传感器包括分析部分，其包括工作电极，对电极和试剂部分。 试剂部分包括与血液成分和介体反应的氧化还原酶，并且通过在介体存在下引起血液成分和氧化还原酶之间的氧化还原反应来测定血液成分，并检测由氧化还原反应产生的氧化还原电流 通过工作电极和对电极。 在该传感器中，试剂部还含有用于溶血红细胞的溶血剂（例如胆酸钠），当检测到氧化还原电流时，红细胞用溶血剂溶血，使血红蛋白释放到红细胞外 与介体反应，并且检测由该反应产生的电流以校正血细胞比容的影响。