公开(公告)号：US20100266100A1

公开(公告)日：2010-10-21

申请号：US12785434

申请日：2010-05-22

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  H01J37/147

CPC classification number: A61N5/10 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a charged particle beam path coupling an injector, synchrotron accelerator, beam transport system, targeting system, and/or patient interface method and apparatus. Preferably, the injector comprises: a negative ion beam source, a two phase ion source vacuum system, an ion beam focusing lens, and/or a tandem accelerator. Preferably, the synchrotron comprises turning magnets, edge focusing magnets, magnetic field concentration magnets, winding and correction coils, flat magnetic field incident surfaces, and/or extraction elements. Preferably, the synchrotron, beam transport system, targeting system, and patient interface combine to allow multi-axis/multi-field irradiation, where multi-axis control comprises control of horizontal and vertical beam position, beam energy, and/or beam intensity and multi-field control comprises control of patient rotation and distribution of delivered energy in and about the tumor in a time controlled, targeted, accurate, precise, dosage controlled, and/or efficient manner.

Abstract translation: 本发明包括连接注射器，同步加速器，束输送系统，靶向系统和/或患者接口方法和装置的带电粒子束路径。 优选地，喷射器包括：负离子束源，两相离子源真空系统，离子束聚焦透镜和/或串联加速器。 优选地，同步加速器包括转动磁体，边缘聚焦磁体，磁场集中磁体，绕组和校正线圈，平坦磁场入射表面和/或提取元件。 优选地，同步加速器，光束传输系统，瞄准系统和患者接口组合以允许多轴/多场照射，其中多轴控制包括水平和垂直光束位置，光束能量和/或光束强度的控制，以及 多场控制包括以时间控制的，靶向的，准确的，精确的，剂量控制的和/或有效的方式来控制患者旋转和在肿瘤中和周围分布的能量。

公开(公告)号：US20100128846A1

公开(公告)日：2010-05-27

申请号：US12637918

申请日：2009-12-15

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00 ,  G01N23/04 ,  H01J35/14

CPC classification number: A61N5/1049 ,  A61N5/1064 ,  A61N2005/1061 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises an X-ray system that is orientated to provide X-ray images of a patient in the same orientation as viewed by a proton therapy beam, is synchronized with patient respiration, is operable on a patient positioned for proton therapy, and does not interfere with a proton beam treatment path. Preferably, the synchronized system is used in conjunction with a negative ion beam source, synchrotron, and/or targeting method apparatus to provide an X-ray timed with patient respiration and performed immediately prior to and/or concurrently with particle beam therapy irradiation to ensure targeted and controlled delivery of energy relative to a patient position resulting in efficient, precise, and/or accurate noninvasive, in-vivo treatment of a solid cancerous tumor with minimization of damage to surrounding healthy tissue in a patient using the proton beam position verification system.

Abstract translation: 本发明包括X射线系统，该X射线系统被定向以提供与质子治疗束相同的取向的患者的X射线图像，与患者呼吸同步，可对位于质子治疗的患者进行操作，并且 不干扰质子束处理路径。 优选地，同步系统与负离子束源，同步加速器和/或靶向方法装置结合使用以提供与患者呼吸定时并在颗粒束治疗照射之前和/或同时进行的X射线，以确保 靶向和受控的相对于患者位置的能量传递，导致使用质子束位置验证系统以最小化对患者周围健康组织的损伤的最小化对固体癌性肿瘤的有效，精确和/或准确的非侵入性，体内治疗 。

公开(公告)号：US20100059687A1

公开(公告)日：2010-03-11

申请号：US12618718

申请日：2009-11-14

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J3/14

CPC classification number: H05H7/10 ,  A61N5/1048 ,  A61N5/1067 ,  A61N2005/1087 ,  H01J3/04 ,  H01J3/14 ,  H05H13/04

Abstract: The invention comprises a proton beam positioning method and apparatus used in conjunction with multi-axis charged particle radiation therapy of cancerous tumors. The proton beam verification system allows for monitoring of the actual proton beam position in real-time without destruction of the proton beam. The system includes a coating or thin layer substantially in contact with a foil covering the end of an exit nozzle or is a layer located after the x- and y-axis proton beam scanning controllers and before the patient. The coating yields a measurable spectroscopic response, spatially viewable by the detector, as a result of transmission by the proton beam. The proton beam position is monitored by the detector and compared to the calibration and/or treatment plan to verify accurate proton delivery to the tumor and/or as a proton beam shutoff safety indicator.

Abstract translation: 本发明包括与癌肿瘤的多轴带电粒子放射治疗结合使用的质子束定位方法和装置。 质子束验证系统允许实时监测实际的质子束位置，而不破坏质子束。 该系统包括基本上与覆盖出口喷嘴的端部的箔接触的涂层或薄层，或者是位于x轴和y轴质子束扫描控制器之后且位于患者之前的层。 作为质子束传输的结果，涂层产生可测量的光谱响应，由检测器空间可见。 质子束位置由检测器监测，并与校准和/或治疗计划进行比较，以验证对肿瘤的精确质子传递和/或作为质子束截止安全指示剂。

公开(公告)号：US20100059686A1

公开(公告)日：2010-03-11

申请号：US12614733

申请日：2009-11-09

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G21K5/04 ,  H01J3/14

CPC classification number: H05H7/10 ,  A61N2005/1087 ,  H01J3/04 ,  H01J3/14 ,  H05H5/06 ,  H05H13/04

Abstract: The invention comprises a tandem accelerator method and apparatus, which is part of an ion beam injection system used in conjunction with multi-axis charged particle radiation therapy of cancerous tumors. The negative ion beam source includes an injection system vacuum system and a synchrotron vacuum system separated by a foil, where negative ions are converted to positive ions. The foil is sealed to the edges of the vacuum tube providing for a higher partial pressure in the injection system vacuum chamber and a lower pressure in the synchrotron vacuum system. Having the foil physically separating the vacuum chamber into two pressure regions allows for fewer and/or smaller pumps to maintain the lower pressure system in the synchrotron as the inlet hydrogen gas is extracted in a separate contained and isolated space by the injection partial vacuum system.

Abstract translation: 本发明包括串联加速器方法和装置，其是与癌性肿瘤的多轴带电粒子放射治疗结合使用的离子束注射系统的一部分。 负离子束源包括注射系统真空系统和由箔分离的同步加速器真空系统，其中负离子转化为正离子。 箔片密封到真空管的边缘，在注射系统真空室中提供较高的分压，并且在同步加速器真空系统中具有较低的压力。 将真空室物理分离成两个压力区域的箔允许更少和/或更小的泵维持同步加速器中的较低压力系统，因为入口氢气通过注射部分真空系统在单独的包含和隔离的空间中提取。

公开(公告)号：US20100046697A1

公开(公告)日：2010-02-25

申请号：US12606913

申请日：2009-10-27

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H05G1/60 ,  G01N23/00

CPC classification number: H05H7/10 ,  A61B6/4258 ,  A61N5/1049 ,  A61N2005/1061 ,  A61N2005/1087 ,  H01J3/029 ,  H01J35/06 ,  H01J35/14 ,  H05H13/04

Abstract: The invention comprises an X-ray tomography method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. In various embodiments, 3-D images are generated from a series of 2-D X-rays images; the X-ray source and detector are stationary while the patient rotates; the 2-D X-ray images are generated using an X-ray source proximate a charged particle beam in a charged particle cancer therapy system; and the X-ray tomography system uses an electron source having a geometry that enhances an electron source lifetime, where the electron source is used in generation of X-rays. The X-ray tomography system is optionally used in conjunction with systems used to both move and constrain movement of the patient, such as semi-vertical, sitting, or laying positioning systems. The X-ray images are optionally used in control of a charged particle cancer therapy system.

Abstract translation: 本发明包括与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用的X射线断层摄影方法和装置。 在各种实施例中，从一系列2-D X射线图像生成3-D图像; X射线源和检测器在患者旋转时是静止的; 使用在带电粒子癌症治疗系统中的带电粒子束附近的X射线源产生2-D X射线图像; 并且X射线断层摄影系统使用具有增强电子源寿命的几何形状的电子源，其中电子源用于产生X射线。 X射线断层摄影系统可选地与用于移动和约束患者运动的系统结合使用，例如半垂直，坐着或铺设定位系统。 X射线图像任选用于控制带电粒子癌症治疗系统。

公开(公告)号：US20100027745A1

公开(公告)日：2010-02-04

申请号：US12554913

申请日：2009-09-06

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: H05H13/04 ,  A61B6/04 ,  A61B6/4028 ,  A61B6/4092 ,  A61N5/1049 ,  A61N2005/1087 ,  H05H7/08 ,  H05H7/12

Abstract: The invention comprises a laying, semi-vertical, or seated patient positioning, alignment, and/or control method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. Patient positioning constraints are used to maintain the patient in a treatment position, including one or more of: a seat support, a back support, a head support, an arm support, a knee support, and a foot support. One or more of the positioning constraints are movable and/or under computer control for rapid positioning and/or immobilization of the patient. The system optionally uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Abstract translation: 本发明包括与癌症肿瘤的多轴带电粒子或质子束放射治疗结合使用的铺设，半垂直或就座的患者定位，对准和/或控制方法和装置。 患者定位限制用于将患者维持在治疗位置，包括以下中的一个或多个：座椅支撑件，背部支撑件，头部支撑件，手臂支撑件，膝盖支撑件和脚部支撑件。 一个或多个定位限制是可移动的和/或在计算机控制下，用于病人的快速定位和/或固定。 系统可选地使用位于与粒子束癌治疗系统的质子束路径基本相同的路径中的X射线束。 生成的图像可用于：相对于质子束路径精细调整身体对准，以控制质子束路径以准确且精确地靶向肿瘤，和/或在系统验证和验证中。

公开(公告)号：US20100008469A1

公开(公告)日：2010-01-14

申请号：US12492515

申请日：2009-06-26

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  H01J35/00

CPC classification number: A61N5/1049 ,  A61N2005/1061 ,  A61N2005/1087 ,  H01J3/14 ,  H05H7/10 ,  H05H13/04

Abstract: The system uses an X-ray imaging system having an elongated lifetime. Further, the system uses an X-ray beam that lies in substantially the same path as a charged particle beam path of a particle beam cancer therapy system. The system creates an electron beam that strikes an X-ray generation source located proximate to the charged particle beam path. By generating the X-rays near the charged particle beam path, an X-ray path running collinear, in parallel with, and/or substantially in contact with the charged particle beam path is created. The system then collects X-ray images of localized body tissue region about a cancerous tumor. Since, the X-ray path is essentially the charged particle beam path, the generated image is usable for precisely target the tumor with a charged particle beam.

Abstract translation: 该系统使用具有延长寿命的X射线成像系统。 此外，该系统使用位于与粒子束癌治疗系统的带电粒子束路径基本相同的路径中的X射线束。 该系统产生电子束，该电子束撞击位于带电粒子束路径附近的X射线产生源。 通过在带电粒子束路径附近产生X射线，产生与带电粒子束路径并联并且/或基本上与带电粒子束路径接触的X射线路径。 然后系统收集关于癌性肿瘤的局部的身体组织区域的X射线图像。 由于X射线路径基本上是带电粒子束路径，所以生成的图像可用于用带电粒子束精确地靶向肿瘤。

公开(公告)号：US20100008468A1

公开(公告)日：2010-01-14

申请号：US12492216

申请日：2009-06-26

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  A61N5/00

CPC classification number: A61N5/1049 ,  A61N2005/1061 ,  A61N2005/1087

Abstract: The invention comprises an X-ray method and apparatus used in conjunction with charged particle or proton beam radiation therapy of cancerous tumors. The system uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The system creates an electron beam that strikes an X-ray generation source where the X-ray generation source is located proximate to the proton beam path. By generating the X-rays near the proton beam path, an X-ray path that is essentially the proton beam path is created. Using the generated X-rays, the system collects X-ray images of a localized body tissue region about a cancerous tumor. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Abstract translation: 本发明包括与癌性肿瘤的带电粒子或质子束放射治疗结合使用的X射线方法和装置。 该系统使用位于与粒子束癌治疗系统的质子束路径基本相同的路径上的X射线束。 该系统产生电子束，该电子束撞击X射线发生源，其中X射线产生源位于质子束路径附近。 通过在质子束路径附近产生X射线，产生基本上是质子束路径的X射线路径。 使用生成的X射线，系统收集关于癌性肿瘤的局部的身体组织区域的X射线图像。 生成的图像可用于：相对于质子束路径精细调整身体对准，以控制质子束路径以准确且精确地靶向肿瘤，和/或在系统验证和验证中。

公开(公告)号：US20090309046A1

公开(公告)日：2009-12-17

申请号：US12464816

申请日：2009-05-12

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00 ,  A61N5/10

CPC classification number: H05H13/04 ,  A61N5/1049 ,  A61N5/1067 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1087

Abstract: The invention relates generally to treatment of solid cancers. More particularly, the invention relates to a multi-field imaging and/or a multi-field charged particle cancer therapy method and apparatus coordinated with patient respiration via use of feedback sensors used to monitor and/or control patient respiration. Preferably, the multi-field imaging, such as X-ray imaging, and the charged particle therapy are performed on a patient in a partially immobilized and repositionable position. X-ray and/or proton delivery is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus.

Abstract translation: 本发明一般涉及固体癌的治疗。 更具体地，本发明涉及通过使用用于监测和/或控制患者呼吸的反馈传感器与患者呼吸配合的多场成像和/或多场带电粒子癌治疗方法和装置。 优选地，多场成像，例如X射线成像和带电粒子治疗在部分固定和可重新定位的位置上对患者进行。 通过控制带电粒子束注射，加速，提取和/或靶向方法和装置，将X射线和/或质子传递定时到患者呼吸。

公开(公告)号：US11648420B2

公开(公告)日：2023-05-16

申请号：US15212005

申请日：2016-07-15

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  A61B6/02 ,  A61B6/00 ,  G21K1/093 ,  G21K1/087 ,  A61B6/03 ,  G21K5/04

CPC classification number: A61N5/1039 ,  A61B6/025 ,  A61B6/03 ,  A61B6/4028 ,  A61B6/4216 ,  A61B6/4258 ,  A61B6/5205 ,  A61N5/1047 ,  A61N5/1067 ,  A61N5/1071 ,  A61N5/1075 ,  A61N5/1077 ,  A61N5/1081 ,  A61N5/1082 ,  G21K1/087 ,  G21K1/093 ,  G21K5/04 ,  A61N5/107 ,  A61N2005/1054 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1097

Abstract: The invention relates to a method and apparatus for control of a charged particle cancer therapy system. A treatment delivery control system is used to directly control multiple subsystems of the cancer therapy system without direct communication between selected subsystems, which enhances safety, simplifies quality assurance and quality control, and facilitates programming. For example, the treatment delivery control system directly controls one or more of: an imaging system, a positioning system, an injection system, a radio-frequency quadrupole system, a ring accelerator or synchrotron, an extraction system, a beam line, an irradiation nozzle, a gantry, a display system, a targeting system, and a verification system. Generally, the control system integrates subsystems and/or integrates output of one or more of the above described cancer therapy system elements with inputs of one or more of the above described cancer therapy system elements.