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71.发明授权公开(公告)号：US09505724B2
公开(公告)日：2016-11-29
申请号：US14817683
申请日：2015-08-04
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K31/517 , C07D239/70 , C07C53/18 , C07D405/04 , C07D239/94
CPC分类号： C07D239/70 , A61K31/517 , C07C53/18 , C07D239/94 , C07D405/04
摘要： The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
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72.发明申请TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A MATRIX 审中-公开抗菌固定剂量组合，从颗粒和基质提供两种药物的快速释放公开(公告)号：US20160310486A1
公开(公告)日：2016-10-27
申请号：US15135588
申请日：2016-04-22
申请人： GRÜNENTHAL GMBH
发明人： Klaus WENING , Lutz BARNSCHEID , Anja GEIßLER , Jana DENKER , Jessica REDMER
IPC分类号： A61K31/485 , A61K9/20 , A61K31/167 , A61K9/16 , A61K9/48 , A61K45/06
CPC分类号： A61K31/485 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K9/2031 , A61K9/4866 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/192 , A61K31/407 , A61K45/06 , A61K2300/00
摘要： A tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.
摘要翻译： 包含两种药理学活性成分的抗篡改药物剂型，其中所述剂型在体外条件下提供快速释放，优选根据Ph.Eur。立即释放两种药理活性成分。 剂型可用于药物联合治疗，其通过施用含有多于一种药理学活性成分的剂型作为固定剂量组合来实现。
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73.发明申请TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A POWDER 审中-公开抗菌固定剂量组合提供从颗粒和粉末中快速释放两种药物公开(公告)号：US20160310427A1
公开(公告)日：2016-10-27
申请号：US15135594
申请日：2016-04-22
申请人： GRÜNENTHAL GMBH
发明人： KLAUS WENING , LUTZ BARNSCHEID , ANJA GEISSLER , JANA DENKER , JESSICA REDMER
IPC分类号： A61K9/16 , A61K31/137 , A61K9/48 , A61K31/485 , A61K31/167
CPC分类号： A61K9/1641 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/1694 , A61K9/4808 , A61K9/4825 , A61K9/4866 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/192 , A61K31/407 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： A tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.
摘要翻译： 包含两种药理学活性成分的抗篡改药物剂型，其中所述剂型在体外条件下提供快速释放，优选根据Ph.Eur。立即释放两种药理活性成分。 剂型可用于药物联合治疗，其通过施用含有多于一种药理学活性成分的剂型作为固定剂量组合来实现。
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74.发明申请FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES AS CAV2.2 CALCIUM CHANNEL BLOCKERS 有权作为CAV2.2钙通道阻断剂的氟甲基取代的吡咯烷公开(公告)号：US20160289214A1
公开(公告)日：2016-10-06
申请号：US15185124
申请日：2016-06-17
申请人： GRÜNENTHAL GMBH
发明人： Melanie REICH , Stefan SCHUNK , Florian JAKOB , Henning STEINHAGEN , Nils DAMANN , Michael HAURAND , Marc ROGERS , Kathy MACKENZIE
IPC分类号： C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D401/04 , C07D409/04
CPC分类号： C07D403/04 , C07D401/04 , C07D403/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
摘要翻译： 本发明涉及带有氟甲基部分作为电压门控钙通道阻断剂的吡咯甲酰胺，含有这些化合物的药物组合物以及用于治疗和/或预防疼痛和其它疾病和/或障碍的这些化合物。
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75.发明申请公开(公告)号：US20160271066A1
公开(公告)日：2016-09-22
申请号：US15166573
申请日：2016-05-27
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K9/20 , A61K31/135
CPC分类号： A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K9/2095 , A61K31/135 , A61K47/32
摘要： The invention relates to a pharmaceutical dosage form having a breaking strength of at least 300 N and comprising a pharmacologically active compound, an anionic polymer bearing carboxylic groups, wherein the content of the anionic polymer is ≧20 wt.-%, based on the total weight of the pharmaceutical dosage form, and a nonionic surfactant.
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公开(公告)号：US20160184295A1
公开(公告)日：2016-06-30
申请号：US15059730
申请日：2016-03-03
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K31/485 , A61K9/00 , A61K9/20 , A61K9/28
CPC分类号： A61K9/2031 , A61K9/0002 , A61K9/0053 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2068 , A61K9/2095 , A61K9/28 , A61K9/2893 , A61K31/485
摘要： The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
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公开(公告)号：US20160120810A1
公开(公告)日：2016-05-05
申请号：US14994691
申请日：2016-01-13
申请人： Grünenthal GmbH
IPC分类号： A61K9/20 , A61K9/28 , A61K31/277 , A61K31/55 , B29B9/02 , A61K31/135 , A61K31/485 , B29C43/02 , B29B9/12 , B29B7/00 , A61K31/554 , A61K31/4422
摘要： The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
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78.发明授权Method and device for supplying liquids to analysis units and liquid handling systems 有权用于向分析单元和液体处理系统供应液体的方法和装置公开(公告)号：US09234630B2
公开(公告)日：2016-01-12
申请号：US13817053
申请日：2011-08-04
申请人： Martin Fuhr , Stefan Oberbörsch , Martin Metzger , Manfred Lorenz
发明人： Martin Fuhr , Stefan Oberbörsch , Martin Metzger , Manfred Lorenz
CPC分类号： F17D1/08 , G01F23/20 , G01G17/06 , G01N30/32 , G01N35/1095 , G01N2030/324 , Y10T137/0318 , Y10T137/7287
摘要： The invention relates to a method for supplying at least one analysis apparatus with at least one liquid. In the method, the liquid is kept available in a storage tank, from where it is transported into at least one buffer tank. The liquid is fed to the analysis apparatus from the buffer tank, whose filling level is monitored. Here, the buffer tank is arranged above the analysis apparatus and the storage tank is arranged below the analysis apparatus. The invention also relates to a device for carrying out this method as well as to an analysis apparatus in which this device is employed.
摘要翻译： 本发明涉及一种用于向至少一个分析装置供应至少一种液体的方法。 在该方法中，液体保存在储存罐中，从其被输送到至少一个缓冲罐中。 将液体从缓冲罐供给到分析装置，该缓冲罐的灌装液位被监测。 这里，缓冲罐配置在分析装置的上方，储罐配置在分析装置的下方。 本发明还涉及一种用于执行该方法的装置以及使用该装置的分析装置。
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公开(公告)号：US09206156B2
公开(公告)日：2015-12-08
申请号：US13710604
申请日：2012-12-11
IPC分类号： C07D401/12 , C07D401/14 , C07D409/14
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： Substituted indole derivatives, processes for the preparation thereof, medicinal products and pharmaceutical compositions containing these compounds and the use of substituted indole derivatives to treat pain and other conditions and for other medical purposes.
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公开(公告)号：US09206136B2
公开(公告)日：2015-12-08
申请号：US14152695
申请日：2014-01-10
申请人： Grünenthal GmbH
发明人： Sonja Nordhoff , Sebastian Wachten , Achim Kless , Felix Voss , Stefanie Ritter
IPC分类号： C07D231/14 , C07D405/14 , C07D403/04 , C07D405/10 , C07D401/12 , C07D417/14 , C07D417/10 , C07D401/10 , C07D413/14 , C07D401/14 , C07D403/10 , C07D413/10
CPC分类号： C07D231/14 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要： The invention relates to pyrazolyl-based carboxamide compounds useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to these compounds for the use in the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.
摘要翻译： 本发明涉及可用作ICRAC抑制剂的基于吡唑基的羧酰胺化合物，含有这些化合物的药物组合物和用于治疗和/或预防疾病和/或病症，特别是炎性疾病和/或炎症性疾病的化合物 。
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