公开(公告)号：US20050266066A1

公开(公告)日：2005-12-01

申请号：US10969543

申请日：2004-10-20

申请人： Tetsuya Uchida ,  Masato Mori

发明人： Tetsuya Uchida ,  Masato Mori

IPC分类号： A61K9/127 ,  A61K39/385

CPC分类号： A61K39/385 ,  A61K9/1271 ,  A61K2039/6018

摘要： The present invention aims at providing a phospholipid membrane preparation wherein an antigen or an allergen is bound onto the surface of a phospholipid membrane comprising a phospholipid containing an acyl group or a hydrocarbon group having 10 to 12 carbon atoms, and a stabilizer of a phospholipid membrane. The present invention provides a phospholipid membrane preparation having an immune response controlling function that suppresses production of IgE antibody to increases production of practically sufficient IgG antibody and usable as a vaccine that does not easily cause an allergic response.

摘要翻译： 本发明的目的在于提供一种磷脂膜制剂，其中抗原或变应原结合在包含含有碳原子数为10〜12的烃基的磷脂的磷脂膜的表面上，磷脂膜的稳定剂 。 本发明提供一种具有免疫应答控制功能的磷脂膜制剂，其抑制IgE抗体的产生，以增加实际上足够的IgG抗体的产生并且可用作不容易引起过敏反应的疫苗。

公开(公告)号：US06939980B2

公开(公告)日：2005-09-06

申请号：US10380662

申请日：2001-09-10

申请人： Michimasa Memita ,  Keiji Hirao

发明人： Michimasa Memita ,  Keiji Hirao

IPC分类号： C07C67/58 ,  C10M105/32 ,  C07C51/00 ,  C07C1/00 ,  C07C67/02 ,  C07C3/00

CPC分类号： C10M105/32 ,  C07C67/58 ,  C07C69/58 ,  C07C69/82 ,  C07C69/22 ,  C07C69/44

摘要： A method for producing an ester comprising the steps of reacting an alcohol with a carboxylic acid to obtain a crude esterfied product, adding 5 to 100 parts by weight of a hydrocarbon solvent with respect to 100 parts by weight of the crude esterified product and performing neutralization with an alkali aqueous solution. An alcohol solvent can be added, if necessary. Thus, a method for producing an ester is provided in which a high-quality ester is obtained at a high yield.

摘要翻译： 一种制备酯的方法，包括使醇与羧酸反应以获得粗酯化产物，相对于100重量份粗酯化产物加入5至100重量份的烃溶剂，并进行中和 用碱水溶液。 如有必要，可加入醇溶剂。 因此，提供了以高产率获得高品质酯的酯的制造方法。

公开(公告)号：US06919481B1

公开(公告)日：2005-07-19

申请号：US09959754

申请日：2000-05-17

申请人： Masaki Hayashi ,  Tomoyuki Nakamura ,  Norihisa Ujikawa

发明人： Masaki Hayashi ,  Tomoyuki Nakamura ,  Norihisa Ujikawa

IPC分类号： C07C239/20 ,  C07D211/46 ,  C07D295/24 ,  C08F4/00 ,  C08F257/02 ,  C08F265/04 ,  C08F291/00 ,  C07C259/00

CPC分类号： C07D295/24 ,  C07C239/20 ,  C07D211/46 ,  C08F4/00 ,  C08F257/02 ,  C08F265/04 ,  C08F291/00

摘要： Alkoxyamines containing a vinyl group as represented by the following general formula (1) are produced in a method which comprises a process of heating divinyl benzene, nitroxide compound and organic peroxide up to a temperature at which the organic peroxide decomposes thermally: (In the formula, R1 represents an aryl group or an R2O group, wherein R2 represents a linear or branched alkyl group having 1-12 carbon atoms or a cycloalkyl group. R3 and R4 are each tertiary alkyl group having 4-6 carbon atoms or of cyclic structure where R3 and R4 are connected with each other having a total carbon number of 8-16. In case of cyclic structure, they are optionally substituted either by an alkyl group, an oxo group, a hydroxyl group, an acyloxy group or an alkoxy group.) Furthermore, graft polymers can be produced by the use of high molecular radical polymerization initiators from which an alkoxyamine group suspends.

摘要翻译： 以下述通式（1）表示的含有乙烯基的烷氧基胺是通过将二乙烯基苯，硝基氧化合物和有机过氧化物加热至有机过氧化物分解为热的温度的方法来制造的（式 R 1表示芳基或R 2 O基团，其中R 2表示具有1-12个碳原子的直链或支链烷基 原子或环烷基，R 3和R 4均为具有4-6个碳原子的叔烷基或具有环状结构的叔烷基，其中R 3， 和R 4彼此连接，总碳数为8-16，在环状的情况下，它们任选被烷基，氧代基，羟基， 酰氧基或烷氧基。）此外，接枝聚合物可以通过使用烷氧基胺基团悬浮的高分子量聚合引发剂来制备。

公开(公告)号：US06911072B2

公开(公告)日：2005-06-28

申请号：US10803173

申请日：2004-03-17

申请人： Koji Kada ,  Kouhei Sawada

发明人： Koji Kada ,  Kouhei Sawada

IPC分类号： C01F5/06 ,  C01F5/14 ,  C03C17/25 ,  C09D1/00 ,  H01B3/00 ,  C09D191/00

CPC分类号： C03C17/25 ,  C03C2217/228 ,  C03C2218/11

摘要： An aqueous coating liquid for forming a magnesium oxide film comprising (a) a magnesium carboxylate derived from a carboxylic acid having 1 to 6 carbon atoms, (b) a surfactant, (c) a polyhydric alcohol compound, and (d) a solvent made substantially of water, wherein the magnesium carboxylate is contained in a ratio of 5 wt % or more and 50 wt % or less. The surfactant is contained in a ratio of 0.01 wt % or more and 2.5 wt % or less, and the polyhydric alcohol compound is contained in a ratio of 0.05 wt % or more and 40 wt % or less, based on a weight of the entire coating liquid. The magnesium carboxylate content is the same with or larger than that of the polyhydric alcohol compound, and a total weight of the magnesium carboxylate and the polyhydric alcohol compound is 80 wt % or less of the weight of the entire coating liquid; and wherein the magnesium carboxylate, the surfactant, and the polyhydric alcohol compound are dissolved in the solvent.

摘要翻译： 一种用于形成氧化镁膜的水性涂布液，其包含（a）由具有1至6个碳原子的羧酸衍生的羧酸镁，（b）表面活性剂，（c）多元醇化合物和（d）制成的溶剂 基本上为水，其中羧酸镁的含量为5重量％以上且50重量％以下。 表面活性剂的含量为0.01重量％以上且2.5重量％以下，多元醇化合物的含量相对于整体的重量为0.05重量％以上且40重量％以下 涂液 羧酸镁含量与多元醇化合物的含量相同或更大，羧酸镁和多元醇化合物的总重量为整个涂布液的重量的80重量％或更少; 并且其中羧酸镁，表面活性剂和多元醇化合物溶解在溶剂中。

公开(公告)号：US20050036973A1

公开(公告)日：2005-02-17

申请号：US10859598

申请日：2004-06-03

申请人： Toshinori Sato ,  Yoshiyuki Koyama ,  Tetsuji Yamaoka

发明人： Toshinori Sato ,  Yoshiyuki Koyama ,  Tetsuji Yamaoka

IPC分类号： A61K47/34 ,  A61K47/36 ,  A61K47/48 ,  A61K48/00 ,  C08G65/14 ,  C08G65/329 ,  C08G65/332 ,  C08G65/334 ,  A61K7/06 ,  A61K7/11 ,  C08G63/48 ,  C08G63/91

CPC分类号： C08G65/334 ,  A61K47/34 ,  A61K47/36 ,  A61K47/60 ,  A61K47/61 ,  A61K48/00 ,  A61K48/0041 ,  C08G65/14 ,  C08G65/329 ,  C08G65/3324 ,  C08L2205/05

摘要： The present invention provides a polyethylene glycol derivative having sugar residue-containing side chains and carboxyl group-containing side chains, and a method of preparing the same. The present invention also provides a carrier for drug delivery systems and a carrier for gene transfer, both comprising the polyethylene glycol derivative.

摘要翻译： 本发明提供了含糖残基侧链和含羧基侧链的聚乙二醇衍生物及其制备方法。 本发明还提供了用于药物递送系统的载体和用于基因转移的载体，两者都包含聚乙二醇衍生物。

公开(公告)号：US06852780B2

公开(公告)日：2005-02-08

申请号：US10181834

申请日：2001-11-20

申请人： Takanori Fujita ,  Katsuyoshi Tanaka ,  Toshiaki Takaoka

发明人： Takanori Fujita ,  Katsuyoshi Tanaka ,  Toshiaki Takaoka

IPC分类号： C08F222/10 ,  G02B1/04 ,  C08K5/34 ,  C08K5/08 ,  C08K5/13 ,  C08K5/23

CPC分类号： G02B1/041 ,  C08F222/1006 ,  C08L33/14

摘要： Disclosed are optical materials which effectively absorb UV light up to the long wavelength band, have low specific gravity, and have balanced properties including impact and heat resistances; lenses; and optical material compositions as their starting materials. The composition contains a polymerizable monomer material consisting of at least one di(meth)acrylate of formula (1): (R: CH3 etc., Ph: a phenylene group; x, z: an integer of 1 to 5; y: 0 or 1) and at least one monomer (M) having at least one vinyl group in one molecule other than monomers of formula (1), and an additive selected from component (A1), (A2), or (B), or mixtures thereof, provided that components (A1) and/or (B) is contained, and when component (B) is contained, components (A1) and/or (A2) is also contained: (A1): a chlorinated benzotriazole UV absorber; (A2): a chlorine-free benzotriazole UV absorber; (B): a coloring agent having absorption maximum in 520-650 nm.

摘要翻译： 公开了能够有效地吸收长达波长带的紫外线，具有低比重的光学材料，并具有包括冲击和耐热性在内的平衡性能; 镜片; 和光学材料组合物作为其起始材料。 该组合物包含由至少一种式（1）的二（甲基）丙烯酸酯组成的可聚合单体材料:( R：CH 3等，Ph：亚苯基; x，z：1至5的整数; y：0 或1）和至少一种在除了式（1）单体以外的一个分子中具有至少一个乙烯基的单体（M）和选自组分（A 1），（A 2））或 （A）和/或（B）），并且当含有组分（B）时，组分（A 1）和/或（A 2） ）还包含：（A 1）：氯化苯并三唑UV吸收剂; （A 2）：无氯苯并三唑UV吸收剂; （B）：在520-650nm具有最大吸收的着色剂。

公开(公告)号：US20040250745A1

公开(公告)日：2004-12-16

申请号：US10810305

申请日：2004-03-26

申请人： NOF Corporation

发明人： Atsuhiko Ogura ,  Eui-chul Kang ,  Kazunori Kataoka ,  Yukio Nagasaki

IPC分类号： C30B033/06 ,  C30B001/00

CPC分类号： C30B7/14 ,  C30B7/00 ,  C30B29/48 ,  C30B29/605 ,  Y10T428/2991 ,  Y10T428/2998

摘要： This invention provides PEG-modified semiconductor nanoparticles of which fluorescence intensity is effectively inhibited from lowering, which are capable of forming a stable dispersion in water, and which are capable of bonding easily with biomolecules having specific recognition, as well as methods for conveniently preparing such nanoparticles, and a material for biological diagnosis. The water-soluble PEG-modified semiconductor nanoparticles of the present invention includes a structure having PEG of a number average molecular weight of 300 to 20000 having a thiol group at one end, bonded via cadmium to II-VI semiconductor nanocrystals of a core-shell structure having a ZnX (wherein X stands for O, S, Se, or Te) shell.

摘要翻译： 本发明提供了PEG修饰的半导体纳米粒子，其荧光强度被有效地抑制，能够在水中形成稳定的分散体，并且能够容易地与具有特定识别性的生物分子结合，以及方便地制备 纳米颗粒和用于生物诊断的材料。 本发明的水溶性PEG改性的半导体纳米粒子包括数均分子量为300〜20000的具有一端具有硫醇基的PEG的结构，其通过镉键合到芯壳的II-VI半导体纳米晶体 具有ZnX（其中X代表O，S，Se或Te）壳的结构。

公开(公告)号：US20030216602A1

公开(公告)日：2003-11-20

申请号：US10463547

申请日：2003-06-18

申请人： NOF CORPORATION

发明人： Kenji Sakanoue ,  Kouzoh Sanchika ,  Tohru Yasukohchi

IPC分类号： C07C043/11

CPC分类号： C08G65/2609 ,  C08L2203/02

摘要： Polyethylene glycol for use in fields with application to a living body wherein the sum of the contents of ethylene glycol and diethylene glycol in the polyethylene glycol is less than or equal to that expressed in the following formula nullInull: 1 Sum null null null of null null null ethylene null null null glycol null null null and null null null diethylene null null null glycol null null null contents null null null ( ppm ) = 150 null 2900 null 0.85 ( x - 150 ) / 44 x [ I ] wherein x represents the average molecular weight of the polyethylene glycol, and the polyethylene glycol has an average molecular weight ranging from 190 to 1,050.

公开(公告)号：US20020193640A1

公开(公告)日：2002-12-19

申请号：US10106219

申请日：2002-03-27

申请人： NOF CORPORATION

发明人： Kenji Sakanoue ,  Kouzoh Sanchika ,  Tohru Yasukohchi

IPC分类号： C07C041/03

CPC分类号： C08G65/2609 ,  C08L2203/02

摘要： Polyethylene glycol for use in fields with application to a living body wherein the sum of the contents of ethylene glycol and diethylene glycol in the polyethylene glycol is less than or equal to that expressed in the following formula nullInull: 1 Sum null null null of null null null ethylene null null null glycol null null null and null null null diethylene null null null glycol null null null contents null null null ( ppm ) = 150 null 2900 null 0.85 ( x - 150 ) / 44 x [ I ] wherein x represents the average molecular weight of the polyethylene glycol, and the polyethylene glycol has an average molecular weight ranging from 190 to 1,050.

公开(公告)号：US20020127262A1

公开(公告)日：2002-09-12

申请号：US10059883

申请日：2002-01-29

申请人： NOF Corporation and Mitsuru Akashi

发明人： Mitsuru Akashi ,  Tetsushi Taguchi ,  Akio Kishida ,  Akio Hayashi

IPC分类号： A61L002/00 ,  B05D003/00

CPC分类号： A61K9/0024 ,  A61L27/46

摘要： A method for preparing a hydroxyapatite composite is disclosed. This method comprises alternately soaking a matrix which has been made hydrophilic at least on its surface, in a calcium ion aqueous solution containing calcium ions and substantially free of phosphate ions and in a phosphate ion aqueous solution containing phosphate ions and substantially free of calcium ions to securely form hydroxyapatite at least on the surface of the matrix. Also disclosed is a biocompatible material composed of the hydroxyapatite composite obtained by the method.

摘要翻译： 公开了一种制备羟基磷灰石复合材料的方法。 该方法包括将至少在其表面上形成亲水性的基质，在含有钙离子且基本上不含磷酸根离子的钙离子水溶液中，以及在含有磷酸根离子且基本上不含钙离子的磷酸根离子水溶液 至少在基体的表面上牢固地形成羟基磷灰石。 还公开了由通过该方法获得的羟基磷灰石复合材料组成的生物相容性材料。