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公开(公告)号：US20240325547A1
公开(公告)日：2024-10-03
申请号：US18610001
申请日：2024-03-19
Applicant: Arvinas Operations, Inc.
Inventor： MICHAEL BERLIN , Hanqing Dong , Dan Sherman , Lawrence B. Snyder , Jing Wang , Wei Zhang
CPC classification number: A61K47/55 , A61K45/06 , A61K47/545 , A61P35/00
Abstract: Bifunctional compounds, which find utility as modulators of B-cell lymphoma 6 protein (BCL6; target protein), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a cereblon ligand that binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
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公开(公告)号：US20240325415A1
公开(公告)日：2024-10-03
申请号：US18580005
申请日：2022-07-21
Applicant: Nicoventures Trading Limited
Inventor： Steven L ALDERMAN , Thomas POOLE , Karen TALUSKIE , Kathryn L WILBERDING , Jenni HAWKE , Ashley DAVIES , Michael S DANIEL , Kai TANG , Keyi XU , Karina MCQUILLAN , John CARAWAY
CPC classification number: A61K31/658 , A61K9/006 , A61K36/3482 , A61K45/06 , A61K47/14 , A61K47/32 , A61K47/38 , A61K47/40
Abstract: The present invention relates to compositions comprising active agents formulated for both buccal and gastric delivery wherein the composition also comprises one or more constituent, derivative or extract of cannabis and a further physiologically active agent.
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公开(公告)号：US20240325409A1
公开(公告)日：2024-10-03
申请号：US18587048
申请日：2024-02-26
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Sean RAFFERTY , Sourav GHORAI , Nathaniel Thomas KENTON , Peilin XU , Samuel BARTLETT , Scott MITCHELL , Joseph D. PANARESE , Yat Sun OR
IPC: A61K31/554 , A61K45/06 , A61P31/20 , C07D513/04
CPC classification number: A61K31/554 , A61K45/06 , A61P31/20 , C07D513/04
Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof:
which inhibit the cellular entry of hepatitis B virus (HBV) and/or hepatitis D virus (HDV) or interfere with the function of the life cycle of HBV and/or HDV and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV and/or HDV infection. The invention also relates to methods of treating an HBV and/or HDV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.-
公开(公告)号：US20240325391A1
公开(公告)日：2024-10-03
申请号：US18371626
申请日：2023-09-22
Applicant: Ribon Therapeutics, Inc.
Inventor： Melissa Marie Vasbinder , Lucas J. Utley , Viviana Bozon , Kevin Wayne Kuntz , Sudha Parasuraman , William McCulloch , Nolan Wood
IPC: A61K31/506 , A61K9/14 , A61K45/06
CPC classification number: A61K31/506 , A61K9/14 , A61K45/06
Abstract: The present invention is directed to dosing, dosage regimens, formulations, unit dosage forms, and related, of a PARP7 inhibitor for the treatment of cancer. The present invention is also directed to methods of treating cancer by administering the PARP7 inhibitor in combination with an antibody that binds to PD-1.
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公开(公告)号：US20240325332A1
公开(公告)日：2024-10-03
申请号：US18423548
申请日：2024-01-26
Applicant: Quimica Luar SRL
Inventor： Luis Alberto Arganaras , Adrian Javier Munoz , Roxana Valeria Alasino , Ariel Gustavo Garro , Dante Miguel Beltramo
IPC: A61K31/192 , A61K9/08 , A61K9/19 , A61K33/14 , A61K45/06 , A61P11/00 , A61P31/04 , A61P31/12 , A61P31/22
CPC classification number: A61K31/192 , A61K9/08 , A61K9/19 , A61K33/14 , A61K45/06 , A61P11/00 , A61P31/04 , A61P31/12 , A61P31/22
Abstract: A bactericidal and virucidal pharmaceutical composition for use on epithelial tissues such as pulmonary, nasal and oral tissues, which comprises a non-steroidal anti-inflammatory drug (NSAID) in a concentration between 5 and 500 mM and a salt, being the NSAID preferably solubilized in a hypertonic saline solution applicable in therapies for viral infections of the Herpes simplex type. The composition can be used in therapies for herpes simplex viral infections, be used as a bactericidal mouthwash, or be vehiculated to the lung by using a nebuliser, for cystic fibrosis.
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Patent Agency Ranking
公开(公告)号：US12104185B2
公开(公告)日：2024-10-01
申请号：US18599428
申请日：2024-03-08
Applicant: Halozyme, Inc.
Inventor： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC: C12N9/26 , A61K9/00 , A61K38/00 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34
CPC classification number: C12N9/2474 , A61K9/0019 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34 , C12Y302/01035 , A61K38/00 , C07K2319/30 , G01N2333/926 , G01N2333/928 , Y02A50/30 , A61K38/28 , A61K2300/00 , A61K38/47 , A61K2300/00
Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US12103919B2
公开(公告)日：2024-10-01
申请号：US17829933
申请日：2022-06-01
Applicant: NOVARTIS AG
Inventor： Simone Bonazzi , Artiom Cernijenko , Jennifer Stroka Cobb , Janetta Dewhurst , John Ryan Kerrigan , Gary O'Brien , MooJe Sung , Noel Marie-France Thomsen , Pamela Ting
IPC: C07D401/14 , A61K31/4545 , A61K31/55 , A61K45/06 , C07D405/14
CPC classification number: C07D401/14 , A61K31/4545 , A61K31/55 , A61K45/06 , C07D405/14
Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.
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公开(公告)号：US12102717B2
公开(公告)日：2024-10-01
申请号：US18200055
申请日：2023-05-22
Applicant: Imam Abdulrahman Bin Faisal University
Inventor： Ayhan Bozkurt , Seyda Tugba Gunday Anil , Firdos Alam Khan , Sultan Akhtar
Abstract: The invention pertains to a method for treating a neoplasm, such as colorectal cancer, using hollow silica spheres (“HSS”). It also is directed to a method for making uncalcined HSS, calcined HSS from which phenyl groups have been removed, and HSS incorporating particles of Fe3O4, as well as compositions containing HSS.
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公开(公告)号：US12102716B2
公开(公告)日：2024-10-01
申请号：US17823750
申请日：2022-08-31
Applicant: Imam Abdulrahman Bin Faisal University
Inventor： Ayhan Bozkurt , Seyda Tugba Gunday Anil , Firdos Alam Khan , Sultan Akhtar
Abstract: The invention pertains to a method for treating a neoplasm, such as colorectal cancer, using hollow silica spheres (“HSS”). It also is directed to a method for making uncalcined HSS, calcined HSS from which phenyl groups have been removed, and HSS incorporating particles of Fe3O4, as well as compositions containing HSS.
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公开(公告)号：US20240318175A1
公开(公告)日：2024-09-26
申请号：US18572486
申请日：2022-06-28
Applicant: ALNYLAM PHARMACEUTICALS, INC.
Inventor： ADAM CASTORENO , BHAUMIK A. PANDYA , ELENA CASTELLANOS-RIZALDOS , MARK K. SCHLEGEL , VASANT R. JADHAV
IPC: C12N15/113 , A61K9/00 , A61K45/06 , A61P27/06
CPC classification number: C12N15/113 , A61K9/0048 , A61K45/06 , A61P27/06 , C12N2310/11 , C12N2310/3125 , C12N2310/313 , C12N2310/3513 , C12N2310/3515 , C12N2310/533 , C12N2320/32
Abstract: The disclosure relates to double-stranded ribonucleic acid (dsRNA) compositions targeting MYOC, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of MYOC.
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