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165 条记录 (耗时 0.041 秒)

    Trimeric Peptides for Use in Treating Obesity
    73.
    发明申请
    Trimeric Peptides for Use in Treating Obesity 审中-公开
    用于治疗肥胖症的三聚体肽

    公开(公告)号：US20080200366A1

    公开(公告)日：2008-08-21

    申请号：US11911428

    申请日：2006-04-07

    申请人： Kilian Waldemar Conde Frieboes

    发明人： Kilian Waldemar Conde Frieboes

    IPC分类号： A61K38/02 ,  C07K2/00 ,  A61P3/04 ,  A61P3/00

    CPC分类号： C07K14/68

    摘要： The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.

    摘要翻译： 本发明涉及有效调节一种或多种黑皮质素受体类型的新型肽化合物，治疗中化合物的用途，包括向有需要的患者施用化合物的治疗方法，以及使用 药物制造中的化合物。 本发明的化合物在治疗肥胖以及与肥胖相关的各种疾病或病症方面特别有意义。

    Metallopeptide compounds
    75.
    发明授权
    Metallopeptide compounds 有权
    金属肽化合物

    公开(公告)号：US07385025B2

    公开(公告)日：2008-06-10

    申请号：US11188552

    申请日：2005-07-25

    申请人： Shubh D. Sharma ,  Yi-Qun Shi ,  Ramesh Rajpurohit ,  Hui-Zhi Cai ,  Margarita Bastos

    发明人： Shubh D. Sharma ,  Yi-Qun Shi ,  Ramesh Rajpurohit ,  Hui-Zhi Cai ,  Margarita Bastos

    IPC分类号： A61K38/04 ,  A61K51/08 ,  C07K7/00

    CPC分类号： A61K38/04 ,  A61K38/105 ,  A61K38/34 ,  C07K14/68 ,  A61K2300/00

    摘要： Metallopeptides with a sequence of a biologically active alpha-melanocyte stimulating hormone (α-MSH), gamma-melanocyte stimulating hormone (γ-MSH), or bombesin sequence of length n residues, wherein a residue including a nitrogen atom and sulfur atom each available for complexation to a metal ion is inserted at any position from between the two and three position to the C-terminus side of the n position, or alternatively is substituted for the residue at any position from the three position to the n position, with a metal ion complexed thereto, with any proline (Pro) residue which is either of the two residues on the immediately adjacent N-terminus side of the inserted or substituent residue comprising a nitrogen atom and sulfur atom available for complexation to a metal ion is substituted with a homolog.

    摘要翻译： 具有生物活性α-黑素细胞刺激激素（α-MSH），γ-黑素细胞刺激激素（γ-MSH）或长度为n个残基的铃蟾肽序列的序列的金属肽，其中包含氮原子和硫原子的残基各自可用 用于与金属离子的络合被插入到位于n位置的两个和三个位置到C末端侧的任何位置处，或者替代地在从三个位置到n个位置的任何位置处的残基代替， 金属离子与其中包含可与金属离子络合的氮原子和硫原子的插入或取代残基的直接相邻的N末端侧的两个残基中的任一种的脯氨酸（Pro）残基替换为 同系物

    Novel melanocortin receptor templates, peptides and use thereof
    78.
    发明申请
    Novel melanocortin receptor templates, peptides and use thereof 失效
    新型黑皮质素受体模板，肽及其用途

    公开(公告)号：US20060258590A1

    公开(公告)日：2006-11-16

    申请号：US11491596

    申请日：2006-07-24

    申请人： Carrie Haskell-Luevano

    发明人： Carrie Haskell-Luevano

    IPC分类号： A61K38/22

    CPC分类号： A61K38/04 ,  A61K38/12 ,  C07K14/47 ,  C07K14/68

    摘要： The present invention relates to novel chimeric peptides and templates containing a combination of antagonist and agonist endogenous ligand residues. In particular, the present invention relates to novel chimeric peptides and templates thereof based upon melanocortin agonist peptides and agouti related protein (AGRP). The present invention provides multifunctional chimeric peptides having specific bioactivity at melanocortin receptors and their use as drugs to treat various diseases and conditions.

    摘要翻译： 本发明涉及包含拮抗剂和激动剂内源性配体残基的组合的新型嵌合肽和模板。 特别地，本发明涉及基于黑皮质素激动剂肽和agouti相关蛋白（AGRP）的新型嵌合肽及其模板。 本发明提供了在黑皮质素受体具有特异性生物活性的多功能嵌合肽及其用作治疗各种疾病和病症的药物。

    Melanocortin receptor templates, peptides, and use thereof
    79.
    发明授权
    Melanocortin receptor templates, peptides, and use thereof 失效
    黑皮质素受体模板，肽及其用途

    公开(公告)号：US07084111B2

    公开(公告)日：2006-08-01

    申请号：US10602394

    申请日：2003-06-23

    申请人： Carrie Haskell-Luevano

    发明人： Carrie Haskell-Luevano

    IPC分类号： A01N37/18

    CPC分类号： A61K38/04 ,  A61K38/12 ,  C07K14/47 ,  C07K14/68

    摘要： The present invention relates to novel chimeric peptides and templates containing a combination of antagonist and agonist endogenous ligand residues. In particular, the present invention relates to novel chimeric peptides and templates thereof based upon melanocortin agonist peptides and agouti related protein (AGRP). The present invention provides multifunctional chimeric peptides having specific bioactivity at melanocortin receptors and their use as drugs to treat various diseases and conditions.

    摘要翻译： 本发明涉及包含拮抗剂和激动剂内源性配体残基的组合的新型嵌合肽和模板。 特别地，本发明涉及基于黑皮质素激动剂肽和agouti相关蛋白（AGRP）的新型嵌合肽及其模板。 本发明提供了在黑皮质素受体具有特异性生物活性的多功能嵌合肽及其用作治疗各种疾病和病症的药物。