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    Cosmetic use of an Ophiopogon japonicus active principle
    73.
    发明授权
    Cosmetic use of an Ophiopogon japonicus active principle 有权
    化妆品使用on us活性成分

    公开(公告)号：US08216618B2

    公开(公告)日：2012-07-10

    申请号：US12990556

    申请日：2009-04-30

    申请人： Jean Paufique

    发明人： Jean Paufique

    IPC分类号： A61K36/00 ,  A61K36/8968 ,  A61K8/02 ,  C12P19/00

    CPC分类号： A61K8/97 ,  A61K8/73 ,  A61Q19/007

    摘要： A cosmetic composition includes at least one extract that is obtained from Ophiopogon japonicus as an active ingredient for improving and/or reinforcing the barrier function of the skin. The reinforcing the barrier function of the skin can be for the purpose of hydration. The active ingredient can stimulate the formation of tight junctions or increase of the level of NMFs of the horny layer.

    摘要翻译： 化妆品组合物包含至少一种从日本O is获得的提取物作为改善和/或增强皮肤屏障功能的活性成分。 增强皮肤的屏障功能可以用于水合。 活性成分可以刺激紧密连接的形成或增加角质层的NMF水平。

    NOVEL CELLULOSE AND LIGNO-CELLULOSE ACTIVE PROTEINS
    75.
    发明申请
    NOVEL CELLULOSE AND LIGNO-CELLULOSE ACTIVE PROTEINS 有权

    公开(公告)号：US20120088273A1

    公开(公告)日：2012-04-12

    申请号：US13257255

    申请日：2010-03-17

    申请人： Peter Jan Punt

    发明人： Peter Jan Punt

    IPC分类号： C12P19/00 ,  C12N15/56 ,  C12N15/63 ,  C12N5/07 ,  C12N1/19 ,  C12N1/15 ,  C12N5/04 ,  C12N9/42 ,  C12N1/21

    CPC分类号： C12P19/14 ,  C12P19/02 ,  C12P2201/00

    摘要： The invention relates to a lignocellulose active protein comprising a DUF1996 domain and proteins that additionally comprise a CBM1 domain. Also included in the invention are proteins with a new domain, characterized by the consensus sequence [GA]-[ST]-[IV]-[ILV]-W-[DS]-G-[RIFS]-F-[ND]-[DS]-X (residues 1-12 of SEQ ID NOS:6-7). The invention relates to a lignocellulose active protein comprising a DUF1996 domain and proteins that additionally comprise a CBM1 domain. Also included in the invention are proteins with a new domain, characterized by the consensus sequence [GA]-[ST]-[IV]-[ILV]-W-[DS]-G-[RIFS]-F-[ND]-[DS]-X2[TS]-X2-D-[LIF]-[ND]-K-W-S-W-[GSA]-N-Q-[IV]-[GP]-[PS]-[YW]-X0-4-Q-[YW]-Y-I-H-G-S-X2-[VT]-X2-Y-[ILV]-X[ILV]-S-X2-[FY]-K-N-P-X5-7-Q-G-X-[KR]-I-T [LI]-D-X-[ST]-[AS]-X-W-N-G-Q-[NT]-M-X-R-[IST]-E-L-I-P-Q-T-X6-13-G-X-[KLV]-[FY]-Y-H-F-S-[ILV]-X5-N-A-P-X4-E-H-Q-[ILV]-[AC]-F-F-E-X0-13-S-H-F-T-E-[LM]-K-[YST]-G-W-X0-2-G-X6-33-[LF]-X1-24-I-D-F-[ASD]-X3-8-V-[FL]-[FWY]-X-S-[ENT]-G-X2-5-[AP]-L-X2-4-[AV]-[AV]-X-[PAN]-X3-5-[ANS]-[AT]-[AFS]-[ST]-[DN]-[GS]-[AQ]-D-[FW]-H-{FILV}-G-[EIQV]-L-[ERK]-[ILV]-P-X8-18-E-D-[FWY]-[FY]-[FW]-S-G-[IV]-[FY]-[IV]-E (SEQ ID NOS:6-7) or a sequence that has a high identity with said sequence. These proteins also may or may not include a CBM1 domain. Further part of the invention are nucleic acids coding for these proteins and vectors and transformants with these nucleic acids. The proteins are of use for their own (hemi-)cellulase activity or for enhancing (hemi-)cellulase activity of other enzymes. [TS]-X2-D-[LIF]-[ND]-K-W-S-W-[GSA]-N-Q-[IV]-[GP]-[PS]-[YW]-X0-4-Q-[YW]-Y-I-H-G-S-X2-[VT]-X2-Y-[ILV]-X[ILV]-S-X2-[FY]-K-N-P-X5-7-Q-G-X-[KR]-I-T-[LI]-D-X-[ST]-[AS]-X-W-N-G-Q-[NT]-M-X-R-[IST]-E-L-I-P-Q-T-X6-13-G-X-[KLV]-[FY]-Y-H-F-S-[ILV]-X5-N-A-P-X4-E-H-Q-[ILV]-[AC]-F-F-E-X0-13-S-H-F-T-E-[LM]-K-[YST]-G-W-X0-2-G-X6-33-[LF]-X1-24-I-D-F-[ASD]-X3-8-V-[FL]-[FWY]-X-S-[ENT]-G-X2-5-[AP]-L-X2-4-[AV]-[AV]-X-[PAN]-X3-5-[ANS]-[AT]-[AFS]-[ST]-[DN]-[GS]-[AQ]-D-[FW]-H-{FILV}-G-[EIQV]-L-[ERK]-[ILV]-P-X8-18-E-D-[FWY]-[FY]-[FW]-S-G-[IV]-[FY]-[IV]-E (SEQ ID NO:82) or a sequence that has a high identity with said sequence. These proteins also may or may not include a CBM1 domain. Further part of the invention are nucleic acids coding for these proteins and vectors and transformants with these nucleic acids. The proteins are of use for their own (hemi-)cellulase activity or for enhancing (hemi-)cellulase activity of other enzymes.

    Recombinant β-glucosidase variants for production of soluble sugars from cellulosic biomass
    76.
    发明授权
    Recombinant β-glucosidase variants for production of soluble sugars from cellulosic biomass 有权
    用于从纤维素生物质生产可溶性糖的重组和葡糖苷酶变体

    公开(公告)号：US08143050B2

    公开(公告)日：2012-03-27

    申请号：US12954447

    申请日：2010-11-24

    申请人： Jie Yang ,  Xiyun Zhang ,  Attila Andor

    发明人： Jie Yang ,  Xiyun Zhang ,  Attila Andor

    IPC分类号： C12N9/42 ,  C12P19/02 ,  C12P19/00 ,  C07H21/04

    CPC分类号： C12N9/42 ,  C12N9/2434 ,  C12N9/2445 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01021 ,  Y02E50/16

    摘要： The invention relates to recombinant expression of a variant form of a fungal C1 strain β-glucosidase. The invention also relates to the generation of fermentable sugars from biomass and the production of biofuels by fermentation of the sugars using genetically modified organisms expressing the β-glucosidase variant. The invention provides methods for producing a fermentable sugar, such as glucose, from cellobiose by contacting cellobiose with a recombinant β-glucosidase variant protein, such as a variant protein secreted by a recombinant host cell into culture medium. Methods of the invention may be used for conversion of a biomass substrate to a fermentable sugar, and ultimately to ethanol or other biofuel.

    摘要翻译： 本发明涉及真菌C1菌株和葡萄糖苷酶的变体形式的重组表达。 本发明还涉及通过使用表达“葡糖苷酶”变体的转基因生物体从生物质产生可发酵糖并通过发酵糖生产生物燃料。 本发明提供了通过将纤维二糖与重组体 - 葡糖苷酶变体蛋白（例如由重组宿主细胞分泌的变体蛋白）接触到培养基中来从纤维二糖生产可发酵糖例如葡萄糖的方法。 本发明的方法可用于将生物质底物转化为可发酵的糖，最终转化为乙醇或其他生物燃料。

    METHODS FOR INCREASING THE YIELD OF FERMENTABLE SUGARS FROM PLANT STOVER
    78.
    发明申请
    METHODS FOR INCREASING THE YIELD OF FERMENTABLE SUGARS FROM PLANT STOVER 有权
    从植物油中增加可食用糖的方法

    公开(公告)号：US20120058524A1

    公开(公告)日：2012-03-08

    申请号：US13158558

    申请日：2011-06-13

    申请人： Willem Evert Vermerris ,  Michael R. Ladisch ,  Nathan S. Mosier

    发明人： Willem Evert Vermerris ,  Michael R. Ladisch ,  Nathan S. Mosier

    IPC分类号： C12P19/02 ,  C12P19/00

    CPC分类号： C12P7/10 ,  C12P19/02 ,  C13K1/02 ,  Y02E50/16

    摘要： Methods for increasing yield of fermentable sugars from plant stover are provided. The methods include using plants homozygous for two brown midrib mutations, bm1 and bm3. The methods also include using plants homozygous for a mutation in a gene that results in reduced cinnamyl alcohol dehydrogenase activity, and a mutation in a gene that results in reduced 5-hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity. The methods also include using transgenic plants that have reduced cinnamyl alcohol dehydrogenase activity and reduced 5-hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity in comparison with wild-type plants.

    摘要翻译： 提供了从植物秸秆提高可发酵糖产量的方法。 这些方法包括使用纯合的两个褐色中期突变bm1和bm3的植物。 所述方法还包括使用纯合于基因中的突变的植物，其导致肉桂醇脱氢酶活性降低，以及导致5-羟基二醛/ 5-羟基络合醇O-甲基转移酶活性降低的基因突变。 该方法还包括与野生型植物相比，使用具有降低的肉桂醇脱氢酶活性的转基因植物和降低的5-羟基二醛/ 5-羟基倍酮乙醇O-甲基转移酶活性。

    Meningococcal oligosaccharide linked polysaccharides and diptheria protein conjugate vaccine for all ages
    79.
    发明授权
    Meningococcal oligosaccharide linked polysaccharides and diptheria protein conjugate vaccine for all ages 有权
    脑膜炎球菌寡糖连接多糖和白喉蛋白结合疫苗适用于所有年龄

    公开(公告)号：US08129147B2

    公开(公告)日：2012-03-06

    申请号：US12834532

    申请日：2010-07-12

    申请人： Jeeri R Reddy

    发明人： Jeeri R Reddy

    IPC分类号： C12P19/00 ,  C12P19/26 ,  C12N1/12 ,  C12N1/20 ,  A61K39/095

    CPC分类号： A61K39/095 ,  A61K39/385 ,  A61K2039/55 ,  A61K2039/6037 ,  A61K2039/70 ,  C07K19/00

    摘要： Methods for producing quadrivalent meningococcal meningitis polysaccharide and conjugate vaccines for serotypes A, C, Y and W-135 disclosed. Neisseria meningitidis fastidious medium was designed to maximize the yield of capsular polysaccharides and generate minimal cellular biomass and endotoxin in a short duration of fermentation. The crude polysaccharides are isolated, purified, and mechanically depolymerized by sonication. These purified polysaccharides were found in human clinical trials to be safe and immunogenic against meningococcal disease caused by N. meningitidis A, C, Y and W-135 serogroups in sub-Saharan Africa. In the preferred embodiment, the polysaccharides are conjugated to carrier proteins of diphtheria or tetanus toxiod to an average molecular size of 5100 to 9900 Daltons and provide broad spectrum protection to humans of all ages. Accelerated polysaccharide production and the efficacy of the resulting vaccine are demonstrated.

    摘要翻译： 公开了用于血清型A，C，Y和W-135的四价脑膜炎球菌性脑膜炎多糖和共轭疫苗的制备方法。 设计脑膜炎奈瑟菌脑膜炎培养基以最大化荚膜多糖的产量，并在短时间的发酵中产生最小的细胞生物量和内毒素。 粗多糖被分离，纯化，并通过超声处理机械解聚。 在人类临床试验中发现这些纯化的多糖对撒哈拉以南非洲脑膜炎奈瑟菌A，C，Y和W-135血清群引起的脑膜炎球菌病具有安全性和免疫原性。 在优选的实施方案中，多糖与白喉或破伤风毒素的载体蛋白缀合至平均分子量为5100至9900道尔顿，并为所有年龄的人类提供广谱保护。 证明加速多糖生产和所得疫苗的功效。