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公开(公告)号:US20200069726A1
公开(公告)日:2020-03-05
申请号:US16491709
申请日:2018-03-06
发明人: Shuichi ENDO , Motoi NAKAHARA
IPC分类号: A61K31/734 , A61K9/08 , A61K47/02
摘要: The present invention provides a ready-to-use sterile alginate aqueous solution preparation which is packed in a sealed container or an airtight container and which has storage stability, comprising: (a) a low-endotoxin monovalent metal salt of alginic acid having a weight average molecular weight of 50,000 to 400,000 by a GPC-MALS method; (b) a salt selected from a monovalent metal salt and an ammonium salt; and (c) water, wherein a concentration of the component (a) is 1.5% by mass or more, a concentration of the component (b) is 0.5 to 2% by mass, and a viscosity measured at 20° C. using a rotational viscometer is 2700 mPa·s or more, and a method of producing the same. This alginate aqueous solution preparation is a ready-to-use aqueous solution preparation of a low-endotoxin monovalent metal salt of alginic acid.
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公开(公告)号:US20190167802A1
公开(公告)日:2019-06-06
申请号:US16272713
申请日:2019-02-11
发明人: Hiromitsu ITO , Hirosato FUJII , Motoo YAMAGATA , Daichi TANAKA
IPC分类号: A61K47/44 , A61K9/107 , A23L33/12 , A61K31/202 , A61K9/48 , A61K31/232 , A61K47/24 , A61K9/00 , A61K47/26
摘要: A self-emulsifying composition contains: 70 to 90% by weight of at least one compound selected from the group consisting of ω3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; 0.5 to 6% by weight of water; 1 to 29% by weight of a polyoxyethylene sorbitan fatty acid ester as an emulsifier (optionally including a polyoxyl castor oil, and not including lecithin); and lecithin in an amount of 3 to 40 parts by weight in relation to 100 parts by weight of ω3 polyunsaturated fatty acids and the like. The self-emulsifying composition is excellent in self-emulsifying property, composition dispersibility, emulsion stability, and absorbability, is free from ethanol and polyhydric alcohols or only has such an alcohol added thereto at a reduced concentration, and is useful for foods and pharmaceuticals.
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公开(公告)号:US20190023657A1
公开(公告)日:2019-01-24
申请号:US16138369
申请日:2018-09-21
发明人: Fumihiko SAITOH , Hiroshi NAGASUE
IPC分类号: C07D213/75 , A61K45/06 , A61K31/4418 , C07D401/04 , A61K31/506 , A61K31/4439 , A61K31/444 , C07D213/84 , C07D405/04 , A61K31/4433 , C07D405/14 , C07D213/81 , C07D413/12 , C07D417/04
CPC分类号: C07D213/75 , A61K31/4418 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/00 , A61P9/06 , A61P9/12 , A61P11/00 , A61P11/02 , A61P11/04 , A61P11/06 , A61P13/02 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P19/02 , A61P19/10 , A61P21/00 , A61P21/02 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/16 , A61P25/20 , A61P25/24 , A61P25/28 , A61P29/00 , A61P29/02 , A61P31/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P43/00 , C07B2200/07 , C07C215/44 , C07C271/24 , C07C2602/10 , C07D213/81 , C07D213/84 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D417/04
摘要: The present invention aims to provide a compound having a TrkA inhibitory action, a pharmaceutically acceptable salt thereof, or a solvate thereof, a pharmaceutical composition containing the same as an active ingredient, and a preventive and/or therapeutic agent for medicinal use, in particular for a disease in which TrkA in involved (pain, cancers, inflammation/inflammatory diseases, allergic diseases, skin diseases, neurodegenerative diseases, infectious diseases, Sjogren's syndrome, endometriosis, renal diseases, osteoporosis, and the like). Specifically, the present invention provides a compound or an optical isomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, or the like, the compound represented by formula (I):
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公开(公告)号:US10174025B2
公开(公告)日:2019-01-08
申请号:US15840858
申请日:2017-12-13
发明人: Tsutomu Satoh , Takashi Kudoh , Tetsuo Iwama
IPC分类号: C07D471/04 , C07D403/04 , C07D401/14 , C07D213/73
摘要: The present invention provides a method for manufacturing a compound represented by formula (I). With this method, provided are a method for manufacturing a 4-heteroaryl-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5-carboxylic acid amide derivative; and an intermediate for this manufacturing method.
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公开(公告)号:US10058528B2
公开(公告)日:2018-08-28
申请号:US15269134
申请日:2016-09-19
IPC分类号: A61K31/232 , A61K31/202
CPC分类号: A61K31/232 , A61K31/202
摘要: Compositions and method are disclosed comprising ethyl icosapentate for use in treatment of non-alcoholic steatohepatis (NASH).
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公开(公告)号:US10024869B2
公开(公告)日:2018-07-17
申请号:US15041283
申请日:2016-02-11
发明人: Kamon Shirakawa
IPC分类号: G01N33/68 , G01N33/569 , A61K45/00 , A61P11/00 , A61P31/04
摘要: According to the methods for detecting respiratory infection associated with bacterial infection of the present invention, the values of soluble CD14 antigen subtype (“sCD14-ST”) in the blood sample can be used to select a patient with a respiratory infection to whom the antibiotic can be administered. The methods of this disclosure can also be used to determine the timing for ending administration of the antibiotic to the patient with respiratory infection.
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公开(公告)号:US20170348268A1
公开(公告)日:2017-12-07
申请号:US15684694
申请日:2017-08-23
发明人: Shigeru KIMURA , Hiromitsu ITO , Hirosato FUJII , Motoo YAMAGATA
IPC分类号: A61K31/202 , A61K47/14 , A61K47/10 , A61K31/232 , A61K9/48 , A61K9/107 , A23L33/115 , A61K47/26 , A23L29/10
CPC分类号: A61K31/202 , A23L29/10 , A23L33/115 , A61K9/1075 , A61K9/4858 , A61K31/232 , A61K47/10 , A61K47/14 , A61K47/26
摘要: A self-emulsifying composition contains: 70 to 90% by weight in total of one or more compounds selected from the group consisting of ω3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; 1 to 29% by weight of an emulsifying agent selected from among a polyoxyethylene sorbitan fatty acid ester, a sorbitan fatty acid ester, a glycerin fatty acid ester and a polyoxyl castor oil; and 0.5 to 6% by weight of water when the composition is defined to be 100% by weight as a whole. The self-emulsifying composition is excellent in self-emulsifying property, composition dispersibility, emulsion stability, and absorbability, is free from ethanol and polyhydric alcohols or only has such an alcohol added thereto at a reduced concentration, and is useful for foods and pharmaceuticals.
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88.
公开(公告)号:US09700537B2
公开(公告)日:2017-07-11
申请号:US15431958
申请日:2017-02-14
IPC分类号: A61K31/232 , A61K31/40 , A61K31/366 , A61K31/225 , A61K31/202 , A61K31/22 , A61K31/351
CPC分类号: A61K31/22 , A61K31/202 , A61K31/225 , A61K31/232 , A61K31/351 , A61K31/366 , A61K31/40 , A61K45/06 , A61K2300/00
摘要: Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular event occurring in a hypercholesterolemia patient despite providing the patient with a treatment with HMG-CoA RI or a cardiovascular event occurring in a multiple risk patient.
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89.
公开(公告)号:US20170151206A1
公开(公告)日:2017-06-01
申请号:US15431958
申请日:2017-02-14
IPC分类号: A61K31/232 , A61K31/366 , A61K31/404 , A61K9/00 , A61K31/47 , A61K31/505 , A61K31/44 , A61K31/215 , A61K31/40
CPC分类号: A61K31/22 , A61K31/202 , A61K31/225 , A61K31/232 , A61K31/351 , A61K31/366 , A61K31/40 , A61K45/06 , A61K2300/00
摘要: Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular event occurring in a hypercholesterolemia patient despite providing the patient with a treatment with HMG-CoA RI or a cardiovascular event occurring in a multiple risk patient.
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公开(公告)号:US20170151178A1
公开(公告)日:2017-06-01
申请号:US15420484
申请日:2017-01-31
发明人: Yumio KUDOU , Kuniomi WARABINO , Hiromitsu ITO
IPC分类号: A61K9/28 , A61K31/5383 , A61K31/522 , A61K9/00
CPC分类号: A61K9/2866 , A61K9/0053 , A61K9/2072 , A61K9/2813 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2886 , A61K31/522 , A61K31/5383
摘要: It has been desired to develop a coating composition, which is used for an orally-administered preparation having an improved administering property, and/or an easily administrable preparation that does not affect dissolution property. The present invention provides a coating composition comprising: a first thickener selected from the group consisting of a carboxyvinyl polymer and sodium alginate; a polyvalent metal compound; at least one type of a second thickener selected from the group consisting of xanthan gum, guar gum and sodium alginate, with the proviso that when the first thickener is sodium alginate the second thickener is not sodium alginate; and sucralose.
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