公开(公告)号：US20220267529A1

公开(公告)日：2022-08-25

申请号：US17610738

申请日：2020-05-15

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Fuke Wang ,  Chaobin He ,  Fei Wang ,  Yi Ting Chong

IPC: C08G77/04 ,  A61K6/17 ,  A61K6/62 ,  B33Y70/00

Abstract: Photocurable compositions comprising 20-90% by weight of a polymerizable core resin; 20-90% by weight of a diluent resin miscible with said core resin; and at least about 1% by weight of at least one rheology modifier which is distinct from said diluent resin. Rheology modifiers of the present disclosure include compounds which may form covalent bonds with the core resin or diluent resin and compounds which have a particle size of 1-200 nm. Rheology modifiers which may form covalent bonds have at least one terminal functional group selected from the group consisting of acrylates, methacrylates, epoxides, oxetanes, nitriles, alkenes and alkynes.

公开(公告)号：US11414681B2

公开(公告)日：2022-08-16

申请号：US16430410

申请日：2019-06-03

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Farid Ghadessy ,  Jia Wei Siau ,  Peter Droge ,  Harshyaa Makhija ,  Shree Harsh Vijaya Chandra ,  Sabrina Peter

IPC: C12N9/12 ,  C12N9/22 ,  C12N1/15 ,  C12N1/21 ,  C12P19/34 ,  C12N15/90

Abstract: The present invention refers to lambda integrases comprising at least one amino acid mutation at positions 43, 319 and 336 of the lambda integrase as set forth in SEQ ID NO: 1. The invention further refers to nucleic acid molecules comprising the nucleotide sequence encoding the mutant lambda integrase and to host cells containing these nucleic acid molecules. The invention also refers to methods of recombining a nucleic acid of interest into a target nucleic acid in the presence of the mutant lambda integrase and sequence specific recombination kits.

公开(公告)号：US11413812B2

公开(公告)日：2022-08-16

申请号：US16498808

申请日：2018-03-29

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Weijie Cyrus Beh ,  Yiqi Seow ,  Sau Yin Chin

IPC: B29C64/129 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  B29C64/245 ,  B29C64/255 ,  B29C64/286 ,  B29C64/268

Abstract: Systems and methods for continuous printing of a three-dimensional (3D) object are provided. The system includes a resin tank, an optical image source, a support fluid reservoir and a pumping structure. The resin tank is where the 3D object is printed and includes a print bed to form a base of the 3D object. The optical image source modulates light in accordance with a 3D image to vary a degree and pattern of crosslinking in a photocrosslinkable resin in the resin tank. The support fluid reservoir is in fluid communication with the resin tank and includes a support fluid which is immiscible with the photocrosslinkable resin. And the pumping structure is configured to transfer the support fluid from the support fluid reservoir to the resin tank such that the support fluid rises in the resin tank at a same rate as vertical height of a top of the 3D object as the 3D object is printed on the print bed.

公开(公告)号：US20220243022A1

公开(公告)日：2022-08-04

申请号：US17622358

申请日：2020-08-04

Applicant: Agency for Science, Technology and Research

Inventor： Hong YAN ,  Kui YAO ,  Shuting CHEN ,  Poh Chong LIM

IPC: C08J9/00 ,  C08J9/06 ,  C08J9/12 ,  E04B1/84 ,  G10K11/162

Abstract: A porous composite material (50) for sound absorption and a method (10) of producing the porous composite material (50) are provided. The method (10) includes preparing (12) a mixture of mechano-electrical conversion elements (56) and electro-thermal conversion elements (58) in an organic solvent. The mixture of the mechano-electrical conversion elements (56) and the electro-thermal conversion elements (58) in the organic solvent is mixed (14) with an aqueous solvent to precipitate a piezoelectric hybrid filler material (54). The piezoelectric hybrid filler material (54) is mixed (16) with a precursor. A foaming operation is performed (18) with the precursor to produce the porous composite material (50).

公开(公告)号：US20220227634A1

公开(公告)日：2022-07-21

申请号：US17609071

申请日：2020-05-29

Applicant: Agency for Science, Technology and Research

Inventor： Jinting Cheng ,  Maria Antipina

IPC: C01B33/12

Abstract: A method of producing hollow inorganic microparticles each having a raspberry-like structure is disclosed herein. The method includes forming a suspension comprising hierarchical microparticles directly from mixing of aqueous reactants, wherein the aqueous reactants are aqueous solutions each containing a reactant for forming the hierarchical microparticles, wherein the hierarchical microparticles comprise CaCO3 vaterite particles, adding a base, adding a silica precursor, wherein the base is added prior to adding the silica precursor, and removing the hierarchical microparticles with an acid to obtain the hollow inorganic microparticles each having the raspberry-like structure. A hollow inorganic microparticle having a raspberry-like structure produced according to the method is also disclosed herein.

公开(公告)号：US20220213189A1

公开(公告)日：2022-07-07

申请号：US17560232

申请日：2021-12-22

Applicant: Singapore Health Services PTE LTD ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Hau Wan Leung ,  Andre Boon Hwa CHOO ,  Mei Yee Vanessa DING ,  Shao Weng Daniel TAN ,  Narayanan Gopalakrishna IYER

IPC: C07K16/28 ,  A61P35/00 ,  G01N33/574 ,  A61K47/64 ,  A61K47/68 ,  C07K16/44 ,  A61K51/10 ,  C07K16/30

Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.

公开(公告)号：US20220187532A1

公开(公告)日：2022-06-16

申请号：US17594359

申请日：2020-03-31

Applicant: Agency for Science, Technology and Research ,  Centre National de la Recherche Scientifique ,  Université de Limoges

Inventor： Dinish Unnimadhava Kurup Soudamini Amma ,  Malini Olivo ,  Georges Humbert ,  Flavien Beffara ,  Jean-Louis Auguste

IPC: G02B6/02 ,  G02B6/032 ,  G01N21/65 ,  G01N21/64

Abstract: Various embodiments may provide an optical fiber for sensing an analyte. The optical fiber may include a dielectric core wall defining a hollow space. The optical fiber may also include a cladding layer surrounding the dielectric core wall and spaced apart from the dielectric core wall. The optical fiber may further include a plurality of supports extending from the cladding layer to the dielectric core wall. A thickness of the dielectric core wall may be greater than a thickness of each of the plurality of supports. The dielectric core wall may be configured to carry an optical light for sensing the analyte.

公开(公告)号：US20220169801A1

公开(公告)日：2022-06-02

申请号：US17438773

申请日：2020-04-09

Applicant: Agency for Science, Technology and Research

Inventor： Praveen Thoniyot

IPC: C08G81/02

Abstract: An organic solvent-free method of producing a polyester is disclosed herein. The method may include providing a mixture comprising at least one precursor of the polyester, wherein the at least one precursor is a liquid, and contacting the mixture with a gaseous inorganic acid to produce the polyester. A polyester obtained according to such a method is also disclosed herein.

公开(公告)号：US20220164029A1

公开(公告)日：2022-05-26

申请号：US17599099

申请日：2019-03-29

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Zheng Yang CHIN ,  Kai Keng ANG

IPC: G06F3/01 ,  G06K9/62 ,  G06N20/00

Abstract: Disclosed is a method for classifying signals for movement control of an autonomous vehicle. The method includes receiving first data comprising concurrently recorded electroencephalogram (EEG) and electromyogram (EMG) signals from a user. The data is used to train a classification model based on the recorded signals. The method further involves receiving second data comprising further EEG and EMG signals recorded from the user, comparing the second data to the classification model to determine a user movement represented by the second data, and determining a control signal for controlling the autonomous vehicle, based on the user movement. This may be used in a further method for identifying an event.

公开(公告)号：US20220162335A1

公开(公告)日：2022-05-26

申请号：US17441519

申请日：2020-03-22

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Cheng-I WANG ,  Bei WANG ,  Zi Xian Eve NGOH ,  Wen-Hsin LEE ,  Ching-Wen HUANG ,  Yee Chin, Yvonne YEAP

IPC: C07K16/30 ,  C07K16/28 ,  C07K14/725 ,  A61K39/395 ,  A61K38/17 ,  A61K47/68 ,  A61P35/00

Abstract: We describe an antibody or antigen-binding fragment thereof comprising a heavy chain variable region (VH) sequence and a light chain variable region (VL) sequence of a clone selected from: 5C4, 4H1, 1D2, 1C4, 2B5, 1F1, 1H1, 4A5, 1D8, 1D3, 2F1, 3C6, 3D12, 3A9, 1F4, 1H10, 3C12, 4G11, 4A12, 1A12, 3G12, 4F9, 4G4 and 1E1 which is capable of specifically binding to glypican-3 (GPC-3) (GenBank Accession Number: NP_004475.1), or a sequence having at least 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% sequence identity thereto.