公开(公告)号：US09056071B2

公开(公告)日：2015-06-16

申请号：US13921998

申请日：2013-06-19

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

Inventor： Jerome Estaquier ,  Mireille Laforge ,  Anna Senik

IPC: A61K31/47 ,  A61K38/05 ,  A61K38/00 ,  A61K31/404 ,  A61K31/4525 ,  A61K31/496 ,  A61K31/7072 ,  A61K45/06

CPC classification number: A61K38/05 ,  A61K31/404 ,  A61K31/4525 ,  A61K31/47 ,  A61K31/496 ,  A61K31/7072 ,  A61K38/005 ,  A61K45/06 ,  C07K5/06052 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/463 ,  Y02A50/465

Abstract: A compound is provided which has a structure I: A-B-C and a method for administering the compound is also provided for use in the prophylaxis and/or treatment of a viral infection, and in particular for preventing and/or inhibiting viral replication, in which A is a quinoline or quinoline-like group, B is a sole amino acid or a peptide or polypeptide having a given amino acid sequence, and C is an O-phenoxy group. According to one embodiment, the compound is a protease inhibitor such as a caspase inhibitor, and the inhibitor can be Q-VD-OPh (N-(2-(quinolyl)valylaspartyl-(2,6-difluorophenoxy)methyl ketone), optionally in an O-methylated form. Antiviral compositions and kits are also provided.

Abstract translation: 提供了具有结构I：ABC的化合物，并且还提供了用于施用化合物的方法用于预防和/或治疗病毒感染，特别是用于预防和/或抑制病毒复制，其中A 是喹啉或喹啉类基团，B是唯一的氨基酸或具有给定氨基酸序列的肽或多肽，C是O-苯氧基。 根据一个实施方案，化合物是蛋白酶抑制剂，例如胱天蛋白酶抑制剂，并且抑制剂可以是Q-VD-OPh（N-（2-（喹啉基）缬氨酰天竺葵酰基 - （2,6-二氟苯氧基）甲基酮），任选地 还提供了抗病毒组合物和试剂盒。

公开(公告)号：US20150157997A1

公开(公告)日：2015-06-11

申请号：US14382200

申请日：2013-02-28

Applicant: ISL - Institut franco-allemand de recherches de Saint-Louis ,  CENTRE NATIONALE DE LA RECHERCHE SCIENTIQUE (C.N.R.S)

Inventor： Denis Spitzer ,  Vincent Pichot ,  Benedikt Risse

IPC: B01J3/08 ,  C01B31/06

CPC classification number: B01J3/08 ,  C01B32/25 ,  C06B25/04 ,  C06B25/34

Abstract: The present invention relates to the field of manufacturing nanoparticles, and specifically to a method for manufacturing diamond nanoparticles, or nanodiamonds, by detonation at least one explosive charge, wherein said at least one explosive charge is nanostructured.

Abstract translation: 本发明涉及制造纳米颗粒的领域，具体涉及通过爆炸至少一种炸药来制造金刚石纳米颗粒或纳米金刚石的方法，其中所述至少一种炸药是纳米结构的。

公开(公告)号：US20150094360A1

公开(公告)日：2015-04-02

申请号：US14502768

申请日：2014-09-30

Applicant: Sanofi ,  Universite Pierre et Marie Curie (Paris 6) ,  Centre National De La Recherche Scientifique (C.N.R.S.) ,  Institut National De La Sante Et De La Recherche Medicale (Inserm)

Inventor： Marisol Corral-Debrinski ,  Christophe Lechauve ,  José-Alain Sahel ,  Thomas Debeir

IPC: A61K38/17

CPC classification number: A61K48/0066 ,  A61K38/1722 ,  A61K38/42 ,  A61K48/005 ,  C12N15/113 ,  C12N2310/14 ,  C12N2750/14143 ,  C12N2750/14171

Abstract: The present invention concerns a neuroglobin agonist for use in the treatment or prevention of a mitochondrial disease associated with respiratory chain complex I (RCCI) deficiency and/or respiratory chain complex III (RCCIII) deficiency.

Abstract translation: 本发明涉及用于治疗或预防与呼吸链复合体I（RCCI）缺乏和/或呼吸链复合体III（RCCIII）缺陷相关的线粒体疾病的神经球蛋白激动剂。

公开(公告)号：US20140370529A1

公开(公告)日：2014-12-18

申请号：US14345179

申请日：2012-09-17

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  Universite Paris-Sud 11

Inventor： Myriam Taverna ,  Romain Verpillot ,  Markus Otto ,  Hans Klafki

IPC: G01N33/543

CPC classification number: G01N33/54306 ,  G01N33/6896 ,  G01N2800/2821 ,  G01N2800/52

Abstract: The present invention relates to a method for diagnosing a neurodegenerative disease in a subject, wherein the level of each of at least two catecholamines is measured in a sample of biological fluid from said subject.

Abstract translation: 本发明涉及一种用于诊断受试者的神经变性疾病的方法，其中在来自所述受试者的生物流体样品中测量至少两种儿茶​​酚胺中的每一种的水平。

公开(公告)号：US20030186999A1

公开(公告)日：2003-10-02

申请号：US10372670

申请日：2003-02-25

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIGUE (C.N.R.S.)

Inventor： Laurent Meijer ,  Emile Bisagni ,  Michel Legraverend

IPC: A61K031/52 ,  C07D473/16

CPC classification number: C07D473/16

Abstract: This invention provides 2-, 6, and 9-substituted purine derivatives, particularly 2(1-R hydroxymethylpropylamino)-6-benzylamino-9-isopropyl purine, having, in particular, antiproliferative properties, and suitable for use as pharmaceutical compositions and herbicidal compositions. Also provided are pharmaceutical compositions and herbicidal compositions comprising the 2-, 6, and 9-substituted purine derivatives, and methods of treatment using the 2-, 6, and 9-substituted purine derivatives.

公开(公告)号：US11618827B2

公开(公告)日：2023-04-04

申请号：US17655717

申请日：2022-03-21

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITE PAUL SABATIER TOULOUSE III

Inventor： Christophe Le Roux ,  Francois Martin ,  Pierre Micoud ,  Angela Dumas

IPC: C09C1/30 ,  C01B33/44 ,  C09C1/00

Abstract: A method for preparing a composition including mineral particles functionalized by at least one organic group and having a specific surface defined according to the BET method greater than 500 m2/g, involves: —choosing a phyllosilicate composition, including mineral particles having a thickness of less than 100 nm, a largest dimension of less than 10 μm and belonging to the family of lamellar silicates; —choosing at least one functionalizing agent, from the group formed from the oxysilanes and oxygermanes having at least one organic group, —bringing the phyllosilicate composition into contact with a functionalizing solution including the functionalizing agent, so as to obtain a phyllosilicate composition including mineral particles functionalized by the organic group, while choosing the organic group from the group formed from the cationic heteroaryl groups, the quaternary ammonium groups and the salts of same. The phyllosilicate composition obtained by the method is also described.

公开(公告)号：US10998549B2

公开(公告)日：2021-05-04

申请号：US15736523

申请日：2016-06-15

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

Inventor： Jean-Marie Tarascon ,  Patrick Rozier ,  Biao Zhang ,  Romain Dugas

IPC: H01M4/58 ,  B22F9/00 ,  C22C1/04 ,  B22F9/04 ,  C22C24/00 ,  H01M10/054 ,  H01M4/505 ,  H01M4/525 ,  H01M4/587 ,  C01B25/455 ,  C01B25/37 ,  H01B1/02 ,  C22C1/10

Abstract: The invention relates to a process for the preparation of sodium-based solid compounds, such as sodium-based solid alloys and sodium-based crystalline phases by ball-milling using metallic sodium as starting material.
The invention also relates to some sodium-based crystalline P′2-phases and to Na-based vanadium phosphates phases (Na(3+y)V2(PO4)3) with 0

公开(公告)号：US20200289956A1

公开(公告)日：2020-09-17

申请号：US16892122

申请日：2020-06-03

Applicant: Centre National De La Recherche Scientifique (C.N.R.S) ,  ISL - Institut franco-allemand de recherches de Saint-Louis

Inventor： Benedikt RISSE ,  Dominique HASSLER ,  Denis SPITZER

IPC: B01D9/00 ,  B01J2/04 ,  B01D1/18 ,  B04C9/00

Abstract: A method for preparing organic or inorganic nanoparticles by instantaneous evaporation or flash evaporation, e.g. for the manufacture of nanoparticles of fertilizers, pharmaceutical or phytopharmaceutical active ingredients, or insensitive energy materials.

公开(公告)号：US10556510B2

公开(公告)日：2020-02-11

申请号：US14937718

申请日：2015-11-10

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： Rachid Yazami

IPC: B60L1/00 ,  G01R31/382 ,  G01R31/392

Abstract: Provided are methods, systems and devices for thermodynamically evaluating electrochemical systems and components thereof, including electrochemical cells such as batteries. The present systems and methods are capable of monitoring selected electrochemical cell conditions, such as temperature, open circuit voltage and/or composition, and carrying out measurements of a number of cell parameters, including open circuit voltage, time and temperature, with accuracies large enough to allow for precise determination of thermodynamic state functions and materials properties relating to the composition, phase, states of charge, health and safety and electrochemical properties of electrodes and electrolytes in an electrochemical cell. Thermodynamic measurement systems of the present invention are highly versatile and provide information for predicting a wide range of performance attributes for virtually any electrochemical system having an electrode pair.

公开(公告)号：US10537103B2

公开(公告)日：2020-01-21

申请号：US15537869

申请日：2015-12-17

Applicant: TEREOS STARCH & SWEETENERS BELGIUM ,  UNIVERSITÉ CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

Inventor： Charlotte Gozlan ,  Dorine Belmessieri ,  Marie-Christine Duclos ,  Nicolas Duguet ,  Marc Lemaire ,  Gérard Lina ,  Oana Dumitrescu ,  Andreas Redl

IPC: A61K31/7028 ,  C07H15/04 ,  A61K31/7004 ,  A61P31/04 ,  A01N43/90 ,  A01N43/08 ,  A61K31/341 ,  C07D307/20 ,  A01N43/16

Abstract: A bactericidal or bacteriostatic composition comprising an isomer mixture of monosaccharide alkyl monoethers or monoacetals, its use in the treatment or prevention of Gram-positive bacterial infections, its use as a hygiene or dermatological product for external use and a method for disinfecting surfaces.