公开(公告)号：US20200165671A1

公开(公告)日：2020-05-28

申请号：US16630523

申请日：2018-07-13

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Yuval DOR ,  Ruth SHEMER ,  Benjamin GLASER ,  Judith MAGENHEIM

IPC: C12Q1/6876 ,  C12Q1/6806

Abstract: A method of determining the methylation status of at least one methylation site of a double-stranded DNA molecule is disclosed. The method comprises analyzing the methylation status of both the forward strand and the reverse strand of the DNA molecule.

公开(公告)号：US20190389948A1

公开(公告)日：2019-12-26

申请号：US16407848

申请日：2019-05-09

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Rifaat SAFADI

IPC: C07K16/28 ,  A61K38/17 ,  A61P1/16

Abstract: Method for treating, attenuating and/or preventing progression of a liver disorder in a subject, the method including administering a therapeutically effective amount of an agent capable of interfering with, inhibiting and/or preventing neuroligin 4 (NLGn4)-Neurexin 1-beta (Nrx1b) protein-protein interaction; and compositions including the agent.

公开(公告)号：US10441568B2

公开(公告)日：2019-10-15

申请号：US15560170

申请日：2016-03-24

Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Hadasit Medical Research Services and Development Ltd.

Inventor： Sara Goldstein ,  Amram Samuni ,  Neville Berkman

IPC: A61K31/40 ,  A61K31/445 ,  A61K31/4015 ,  A61K31/45

Abstract: Cyclic nitroxide compounds including, but not limited to, compounds having the general formula I: wherein the dashed line and R1-R8 are as defined herein, are disclosed herein for use in treating diseases and disorders of the respiratory tract and/or respiratory tract remodeling.

公开(公告)号：US10435365B2

公开(公告)日：2019-10-08

申请号：US15126023

申请日：2015-03-16

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. ,  INDIAN INSTITUTE OF SCIENCE

Inventor： Bernard Lerer ,  Mugesh Govindasamy ,  Tzuri Lifschytz

IPC: C07D207/444 ,  A61K31/40 ,  C07D207/456 ,  C07D405/06 ,  C07D517/04 ,  A61P25/24 ,  A61P35/00 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/402

Abstract: The present invention relates to compounds that inhibit the activity of Type III deiodinase (DIO3). The present invention further relates to methods for treating or preventing depression, depression associated with other psychiatric or general medical diseases or conditions, condition amenable to treatment with known anti-depressants and cancer, particularly by using the compounds of the invention.

公开(公告)号：US20190247464A1

公开(公告)日：2019-08-15

申请号：US16392685

申请日：2019-04-24

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Dina Ben Yehuda ,  Ihab Abd-Elrahman ,  Riki Perlman ,  Marjorie Pick

IPC: A61K38/17 ,  C12N5/0789 ,  A61K45/06 ,  A61K35/545 ,  C12N5/078 ,  A61K35/28

CPC classification number: A61K38/1761 ,  A61K35/28 ,  A61K35/545 ,  A61K45/06 ,  C12N5/0644 ,  C12N5/0647 ,  C12N2501/48 ,  C12N2501/727 ,  C12N2501/999

Abstract: Methods of inducing thrombopoiesis and/or treating thrombocytopenia in a subject are provided. Accordingly there is provided a method comprising contacting stem cells with a differentiation potential towards platelets or hematopoietic progenitor cells derived therefrom with Livin, thereby inducing thrombopoiesis. Also provided is a method comprising contacting cells with a differentiation potential towards platelets with tLivin, thereby inducing thrombopoiesis. Also provided are compositions and isolated population of cells for inducing thrombopoiesis and/or treating thrombocytopenia in a subject.

公开(公告)号：US20190137482A1

公开(公告)日：2019-05-09

申请号：US16242023

申请日：2019-01-08

Applicant: Cell Cure Neurosciences Ltd. ,  Hadasit Medical Research Services and Development Ltd.

Inventor： Talya MORDECHAI DANIEL ,  Ofer WISER ,  Benjamin Eithan REUBINOFF

IPC: G01N33/50

Abstract: A method of determining whether an agent is a neuroeffector is disclosed. The method comprises: (a) labeling dopaminergic neurons which are comprised in a mixed population of cells with a fluorescent dopamine analog; (b) measuring a level of fluorescence in the mixed population of cells; (c) exposing the mixed population of cells to the agent; (d) remeasuring a level of fluorescence in the mixed population of cells, wherein a change in the level of fluorescence is indicative of the substance being a neuroeffector.

公开(公告)号：US20190133682A1

公开(公告)日：2019-05-09

申请号：US16304615

申请日：2017-06-15

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.

Inventor： Eyal ITSHAYEK ,  Ram ELAZARY ,  Eitan MELAMED ,  Noam MEYUHAS ,  Amnon BUXBOIM ,  Yoav MINTZ ,  Elchanan FRIED ,  Gahl LEVY

IPC: A61B18/14 ,  A61B18/16

Abstract: Disclosed herein are ablation catheter tips and catheters, and catheter ablation methods, wherein a same channel within the catheter may be simultaneously used both for applying suction and attaching a target tissue to the ablation electrode, and for expelling a coolant introduced into the catheter via a second channel, fluidly coupled thereto.

公开(公告)号：US10188741B2

公开(公告)日：2019-01-29

申请号：US15146045

申请日：2016-05-04

Applicant: GAVISH-GALILEE BIO APPLICATIONS LTD. ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Jacob Pitcovski ,  Ehud Shahar ,  Raphael Gorodetsky

IPC: A61K39/00 ,  A61K39/38 ,  A61K39/395 ,  A61K47/48 ,  A61K9/48 ,  A61K9/50 ,  C07K16/32 ,  A61K47/68 ,  A61K47/69 ,  A61K39/385

Abstract: The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies.

公开(公告)号：US20190000854A1

公开(公告)日：2019-01-03

申请号：US15969181

申请日：2018-05-02

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Yaron ILAN ,  Doina Cosma ROMAN ,  Michael HAYDEN ,  Einat AMIT-ROMACH

IPC: A61K31/52 ,  A61K9/28 ,  A61K45/06 ,  A61K9/00 ,  A61K9/20

CPC classification number: A61K31/52 ,  A61K9/0053 ,  A61K9/20 ,  A61K9/2846 ,  A61K45/06 ,  A61P1/16 ,  A61K2300/00

Abstract: Methods of treating patients suffering from non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), including those also suffering from type II diabetes mellitus (T2DM), with a delayed release pharmaceutical composition comprising 6-mercaptopurine are disclosed.

公开(公告)号：US20180343882A1

公开(公告)日：2018-12-06

申请号：US15778993

申请日：2016-11-29

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Shimon REIF ,  Regina GOLAN

IPC: A23C9/15 ,  A23C9/20 ,  A23L33/00 ,  A23L33/13 ,  A61K9/127 ,  A61K31/7105 ,  A61P35/00

CPC classification number: C12N15/113 ,  A23C9/1512 ,  A23C9/20 ,  A23C2240/05 ,  C12N15/111 ,  C12N2310/141 ,  C12N2320/32

Abstract: Provided are microvesicles isolated from milk, compositions thereof and uses for the preparation of milk formulas. Further provided are microvesicles, including exosomes and/or fat globules which encapsulate various miRNA molecules and uses thereof, as exemplified by supplementing milk formulas.