公开(公告)号：US20230293586A1

公开(公告)日：2023-09-21

申请号：US18296623

申请日：2023-04-06

Applicant: Assistance Publique - Hopitaux de Paris ,  Fondation Imagine - Institut des Maladies Génétiques ,  Université Paris Cité ,  Institut National de la Santé et de la Recherche Médicale (INSERM)

Inventor： Isabelle ANDRÉ ,  Marina CAVAZZANA ,  Kuiying MA ,  John TCHEN ,  Tayebeh-Shabi SOHEILI ,  Ranjita Devi MOIRANGTHEM

IPC: A61K35/17 ,  C12N5/0783

CPC classification number: A61K35/17 ,  C12N5/0636 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/2307 ,  C12N2501/25 ,  C12N2501/26 ,  C12N2501/42 ,  C12N2506/11 ,  C12N2533/52

Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.

公开(公告)号：US11753454B2

公开(公告)日：2023-09-12

申请号：US17068628

申请日：2020-10-12

Applicant: Cytune Pharma ,  INSERM (Institut National De La Santé Et De La Recherche Medicale)

Inventor： Sebastien Daniel Morisseau ,  Geraldine Teppaz ,  Yannick Laurent Joseph Jacques ,  Bruno Gilbert Marc Robert ,  Guy Luc Michel De Martynoff ,  David Bechard

IPC: C07K14/54 ,  A61K38/20 ,  C07K14/715 ,  C07K16/32 ,  C07K16/28 ,  C07K16/30 ,  A61K38/00 ,  A61K39/00

CPC classification number: C07K14/5443 ,  A61K38/2086 ,  C07K14/7155 ,  C07K16/32 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2887 ,  C07K16/3084 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/32 ,  C07K2319/33 ,  C07K2319/74

Abstract: The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an antibody or a fragment thereof directly or indirectly linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and (ii) a polypeptide comprising the amino acid sequence of the sushi domain of the interleukin 15R alpha (IL-15Rα) or derivatives thereof; and uses thereof.

公开(公告)号：US20230279510A1

公开(公告)日：2023-09-07

申请号：US18007667

申请日：2021-05-31

Applicant: Universite Paris Cite ,  Assistance Publique - Hopitaux de Paris ,  Centre National de la Recherche Scientifique ,  Inserm (Instilut National de la Sante et de la Recherche Medicale) ,  Sorbonne Universite

Inventor： Helene Pere ,  David Veyer ,  Valerie Taly ,  Pierre Laurent-Puig

IPC: C12Q1/70

CPC classification number: C12Q1/701 ,  C12Q2600/118 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: The invention relates to methods for quantifying a SARS coronavirus in a blood sample of a subject, and for determining a risk for the subject to develop a severe form of the disease or for the disease to worsen.

公开(公告)号：US20230279422A1

公开(公告)日：2023-09-07

申请号：US17749501

申请日：2022-05-20

Applicant: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE) ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCH MÉDICALE) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS) ,  SORBONNE UNIVERSITE

Inventor： Françoise PIGUET ,  Caroline SEVIN

IPC: C12N15/86 ,  A61K38/46 ,  A61P25/00

CPC classification number: C12N15/86 ,  A61K38/465 ,  C12Y301/06008 ,  A61P25/00 ,  C12N2750/14122 ,  C12N2750/14143 ,  A61K48/00

Abstract: The use of recombinant AAV vectors expressing a molecule of interest in a method for treating diseases or conditions affecting the nervous system in a subject in need thereof, or in a method for increasing or inducing expression of the molecule of interest in the nervous system of a subject.

公开(公告)号：US20230277686A1

公开(公告)日：2023-09-07

申请号：US18004372

申请日：2021-07-09

Applicant: GENETHON ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCH MEDICALE) ,  UNIVERSITE D'EVRY-VAL-D'ESSONNE

Inventor： William LOSTAL ,  Isabelle RICHARD

IPC: A61K48/00 ,  C12N15/86 ,  C12N9/64 ,  C07K14/47 ,  A61P21/00

CPC classification number: A61K48/0058 ,  C12N15/86 ,  C12N9/6472 ,  C12Y304/22054 ,  C07K14/4708 ,  C07K14/47 ,  C07K14/471 ,  A61P21/00 ,  C12N2750/14143 ,  C12N2820/007 ,  C07K2319/00

Abstract: The present invention concerns a novel short promoter characterized by a high activity in the skeletal muscles and a low activity in the heart. It then constitutes a valuable candidate especially for driving the expression of transgenes encoding proteins useful for the treatment of muscular dystrophies.

公开(公告)号：US20230270885A2

公开(公告)日：2023-08-31

申请号：US17753768

申请日：2020-09-18

Applicant: GENETHON ,  UNIVERSITE D’EVRY-VAL-D’ESSONNE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

Inventor： Evelyne GICQUEL ,  Isabelle RICHARD

IPC: A61K48/00 ,  A61K9/00 ,  A61P21/00

CPC classification number: A61K48/0058 ,  A61K48/0008 ,  A61K9/0019 ,  A61P21/00

Abstract: The present invention concerns an expression system for systemic administration comprising a sequence encoding a FKRP protein, and:



a promoter sequence allowing the expression at a therapeutically acceptable level of FKRP in the skeletal muscles and a target sequence of an miRNA expressed in the heart; or
a promoter sequence allowing the expression at a therapeutically acceptable level of FKRP in the skeletal muscles and presenting a promoter activity at a toxically acceptable level in the heart;

and its use for the treatment of various diseases linked to FKRP deficiencies.

公开(公告)号：US20230263843A1

公开(公告)日：2023-08-24

申请号：US18300049

申请日：2023-04-13

Applicant: INSTITUT GUSTAVE ROUSSY ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM ,  UNIVERSITE PARIS-SACLAY ,  Institut national de recherchepour l'agriculture, l'alimentation et l'environnement

Inventor： Laurence ZITVOGEL ,  Bertrand ROUTY ,  Emmanuelle LE CHATELIER

IPC: A61K35/744 ,  A61K39/395 ,  C12Q1/6886 ,  C12Q1/689

CPC classification number: A61K35/744 ,  A61K39/39558 ,  C12Q1/6886 ,  C12Q1/689 ,  A61K2039/55594

Abstract: The invention relates to gut microbiota profiles associated with response or resistance to treatments with ICB, in particular with anti-PD1 or anti PD-L1 or anti-PD-L2 antibodies. In particular, the invention pertains to a theranostic method for identifying good responders, to whom an anti-PD1 or anti PD-L1 or anti-PD-L2 can be administered, while a pre-treatment based on FMT and/or immunogenic probiotics is recommended to bad responders exhibiting a dysbiosis. In particular, the present invention pertains to Akkermansia muciniphila as the main commensal species distinguishing responders from progressors and its use alone or with E. hirae for the treatment of antibiotics or gut repertoire insufficiency-associated dysbiosis.

公开(公告)号：US20230256117A1

公开(公告)日：2023-08-17

申请号：US18001648

申请日：2021-06-18

Applicant: GENETHON ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE D’EVRY-VAL-D’ESSONNE

Inventor： Isabelle RICHARD ,  Jerome POUPIOT

IPC: A61K48/00

CPC classification number: A61K48/0058

Abstract: The present invention concerns an expression system for systemic administration comprising a sequence encoding gamma-sarcoglycan (SGCG) placed under the control of a promoter allowing an adequate expression of SGCG in the skeletal muscles and in the heart, and its use for the treatment of Limb-Girdle Muscular Dystrophy type C.

公开(公告)号：US20230253118A1

公开(公告)日：2023-08-10

申请号：US18004710

申请日：2021-07-12

Applicant: SORBONNE UNIVERSITÉ ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

Inventor： Delphine SAUCE ,  Martin LARSEN

IPC: G16H50/30 ,  G01N33/53

CPC classification number: G16H50/30 ,  G01N33/5308

Abstract: An in vitro method of classifying a subject suspected to suffer from an acute event including the steps of: determining neopterin concentration in a biological sample obtained from the subject, comparing the concentration with a predetermined reference neopterin concentration, and assigning the subject to a risk group based on the comparison of the neopterin concentration with the predetermined reference neopterin concentration.

公开(公告)号：US11717543B2

公开(公告)日：2023-08-08

申请号：US16907381

申请日：2020-06-22

Applicant: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP) ,  ECOLE D'INGENIEURS DE PURPAN

Inventor： Philippe Langella ,  Sylvie Miquel ,  Rebeca Martin Rosique ,  Luis Bermudez Humaran ,  Muriel Thomas ,  Harry Sokol ,  Frédéric Carvalho ,  Vassilia Theodorou

IPC: A61K35/741 ,  A23L33/135 ,  A61P29/00

CPC classification number: A61K35/741 ,  A23L33/135 ,  A61P29/00

Abstract: The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual.
The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.