公开(公告)号：US20080177064A1

公开(公告)日：2008-07-24

申请号：US11928944

申请日：2007-10-30

申请人： Jun Feng ,  Stephen L. Gwaltney ,  Jeffrey A. Stafford ,  Zhiyuan Zhang ,  Bruce J. Elder ,  Paul K. Isbester ,  Grant J. Palmer ,  Jonathon S. Salsbury ,  Luckner G. Ulysse

发明人： Jun Feng ,  Stephen L. Gwaltney ,  Jeffrey A. Stafford ,  Zhiyuan Zhang ,  Bruce J. Elder ,  Paul K. Isbester ,  Grant J. Palmer ,  Jonathon S. Salsbury ,  Luckner G. Ulysse

IPC分类号： C07D223/02 ,  C07D239/24

CPC分类号： C07D403/04 ,  C07D239/545 ,  C07D401/04 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14

摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C═NR9; and each L, X, R1, R2, and R3 are as defined herein.

公开(公告)号：US07381825B2

公开(公告)日：2008-06-03

申请号：US10803575

申请日：2004-03-17

申请人： Jerome C. Bressi ,  Jason W. Brown ,  Sheldon X. Cao ,  Anthony R. Gangloff ,  Andrew J. Jennings ,  Jeffrey A. Stafford ,  Phong H. Vu ,  Xiao-Yi Xiao

发明人： Jerome C. Bressi ,  Jason W. Brown ,  Sheldon X. Cao ,  Anthony R. Gangloff ,  Andrew J. Jennings ,  Jeffrey A. Stafford ,  Phong H. Vu ,  Xiao-Yi Xiao

IPC分类号： C07D401/04

CPC分类号： C07D235/18 ,  C07D401/04 ,  C07D401/06 ,  C07D403/06 ,  C07D403/10

摘要： Compounds that may be used to inhibit histone deacetylase having the formula Z-Q-L-M or Z-L-M wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0-10 atoms separation between the M substituent and the remainder of the compound; and Z and Q are as defined herein.

摘要翻译： 可用于抑制组氨酸脱乙酰酶的化合物，其具有式<？in-line-formula description =“In-line Formulas”end =“lead”？> ZQLM或ZLM <？in-line-formula description =“In-line 式“end =”tail“？>其中M是能够与脱乙酰酶催化部位和/或金属离子络合的取代基; L是在M取代基和化合物的其余部分之间分离0-10个原子之间的取代基; Z和Q如本文所定义。