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    HEMOSTASIS SEALING DEVICE WITH CONSTRICTION RING
    81.
    发明申请
    HEMOSTASIS SEALING DEVICE WITH CONSTRICTION RING 审中-公开

    公开(公告)号：US20200086106A1

    公开(公告)日：2020-03-19

    申请号：US16549564

    申请日：2019-08-23

    Applicant: Surmodics, Inc.

    Inventor： Gregg Stuart Sutton

    IPC: A61M39/06 ,  A61B17/00

    Abstract: Aspects herein relate to a medical device for providing a leak-resistant seal for use in a vascular access device. In various embodiments, a device for vascular access hemostasis is included. The device can include an enclosure configured to at least partially receive a medical device, the enclosure defining a cavity. The enclosure can have a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The enclosure can include the second seal portion comprising a split, septum seal. The enclosure can include a barrel in structural communication with the second seal portion. The device can include a constriction ring disposed around the barrel, the constriction ring interfacing with the second seal portion to limit movement of the split, septum seal.

    Macrolide particulates, methods for preparation, and medical devices associated therewith
    84.
    发明授权
    Macrolide particulates, methods for preparation, and medical devices associated therewith 有权

    公开(公告)号：US10449180B2

    公开(公告)日：2019-10-22

    申请号：US15959589

    申请日：2018-04-23

    Applicant: Surmodics, Inc.

    Inventor： Joram Slager

    IPC: A61K31/435 ,  A61K31/436 ,  A61K9/00 ,  A61K9/107 ,  A61K9/19 ,  A61K9/51 ,  A61L29/08 ,  A61L29/16 ,  A61K9/14 ,  A61K9/16

    Abstract: The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one method the particulates are made by adding a composition containing an polyoxyethylene sorbitan n-acyl ester, poly(ethyleneimine), or alkylated quaternary ammonium salt to a composition including macrolide dissolved in an alcohol such as ethanol. In another method the particulates are made by adding a non-solvent composition to a composition including macrolide and an alkyl-substituted chromanol dissolved in an alcohol such as ethanol. The formed macrolide particulates have one or more desirable properties including sizes in the range of 0.1 μm to 10 μm, spherical or near spherical shapes, low polydispersity, and/or stability. The macrolide particulates can be used for therapeutic compositions, or in association with an implantable or insertable medical device, such as associated with a polymeric coating on a device.

    Delivery of coated hydrophobic active agent particles
    85.
    发明授权
    Delivery of coated hydrophobic active agent particles 有权

    公开(公告)号：US10213529B2

    公开(公告)日：2019-02-26

    申请号：US13793390

    申请日：2013-03-11

    Applicant: SurModics, Inc.

    Inventor： Joram Slager

    IPC: A61L29/16 ,  A61L29/08 ,  A61L29/14 ,  A61K31/337 ,  A61K9/50

    Abstract: Embodiments of the invention include devices and coatings for devices including coated hydrophobic active agent particles. In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a cationic agent in contact with the particulate hydrophobic therapeutic agent. Other embodiments are also included herein.

    Article coatings including oligomerized polyphenol layer and biological methods of use
    86.
    发明授权
    Article coatings including oligomerized polyphenol layer and biological methods of use 有权

    公开(公告)号：US10201637B2

    公开(公告)日：2019-02-12

    申请号：US15502345

    申请日：2015-08-06

    Applicant: SURMODICS, INC.

    Inventor： David E. Babcock ,  Sean Lundquist ,  Gary Opperman ,  Adriyn Torguson ,  Tim Jentz

    IPC: A61L29/08 ,  A61L29/06 ,  A61L29/16 ,  G01N33/543

    Abstract: Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.

    Wound packing device with nanotextured surface
    87.
    发明授权
    Wound packing device with nanotextured surface 有权

    公开(公告)号：US10201457B2

    公开(公告)日：2019-02-12

    申请号：US14813928

    申请日：2015-07-30

    Applicant: SurModics, Inc.

    Inventor： Gary Maharaj ,  Teryl L. Woodwick Sides

    IPC: A61F13/00

    Abstract: Embodiments of the invention include wound packing devices and methods of making and using the same. In an embodiment, the invention includes a wound packing device including a plurality of spacing elements comprising a nanotextured surface. The wound packing device can also include a connector connecting the plurality of spacing elements to one another. Other embodiments are also included herein.

    Apparatus and methods for coating medical devices
    88.
    发明授权
    Apparatus and methods for coating medical devices 有权

    公开(公告)号：US10099041B2

    公开(公告)日：2018-10-16

    申请号：US15783554

    申请日：2017-10-13

    Applicant: Surmodics, Inc.

    Inventor： Ralph A. Chappa ,  Andrew G. Bach ,  Mark MacGregor

    IPC: B05B13/04 ,  A61M25/10

    Abstract: Embodiments herein include apparatus and methods for coating medical devices. In an embodiment, a coating apparatus is included having a coating application unit including a movement restriction structure, a fluid applicator having a lengthwise major axis, a fluid distribution bar having a body angled with respect to the major lengthwise axis of the fluid applicator between 0 and 20 degrees, a rotation mechanism and an axial motion mechanism. The axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.

    DEVICES AND METHODS FOR DELIVERY OF BIOACTIVE AGENTS
    89.
    发明申请
    DEVICES AND METHODS FOR DELIVERY OF BIOACTIVE AGENTS 审中-公开

    公开(公告)号：US20180272040A1

    公开(公告)日：2018-09-27

    申请号：US15994263

    申请日：2018-05-31

    Applicant: Surmodics, Inc.

    Inventor： Ralph A. Chappa ,  Andrew G. Bach

    IPC: A61L29/08 ,  A61L29/16

    CPC classification number: A61L29/085 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/60

    Abstract: Embodiments of the invention include bioactive agent eluting devices. In an embodiment the invention includes a bioactive agent delivery device including a substrate, a hydrophilic polymer disposed on the substrate, and a substantially amorphous bioactive agent disposed on the surface of the hydrophilic polymer. In an embodiment, the invention includes a method of making a bioactive agent delivery device including depositing a hydrophilic polymer on a substrate forming a hydrophilic surface and depositing a substantially amorphous bioactive agent on the hydrophilic surface. In an embodiment, the invention includes a bioactive agent-eluting catheter including a catheter shaft and an expandable balloon disposed on the catheter shaft. Other embodiments are included herein.

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