公开(公告)号：US20170224876A1

公开(公告)日：2017-08-10

申请号：US15502345

申请日：2015-08-06

申请人： SURMODICS, INC.

发明人： David E. Babcock ,  Sean Lundquist ,  Gary Opperman ,  Adriyn Torguson ,  Tim Jentz

IPC分类号： A61L29/08 ,  A61L29/16 ,  G01N33/543 ,  A61L29/06

CPC分类号： A61L29/085 ,  A61K31/7024 ,  A61L27/34 ,  A61L29/06 ,  A61L29/16 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/08 ,  G01N33/54393

摘要： Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological mo lecule.

公开(公告)号：US10201637B2

公开(公告)日：2019-02-12

申请号：US15502345

申请日：2015-08-06

申请人： SURMODICS, INC.

发明人： David E. Babcock ,  Sean Lundquist ,  Gary Opperman ,  Adriyn Torguson ,  Tim Jentz

IPC分类号： A61L29/08 ,  A61L29/06 ,  A61L29/16 ,  G01N33/543

摘要： Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.

公开(公告)号：US11938250B2

公开(公告)日：2024-03-26

申请号：US16272808

申请日：2019-02-11

申请人： Surmodics, Inc.

发明人： David E. Babcock ,  Sean Lundquist ,  Gary Opperman ,  Adriyn Torguson ,  Tim Jentz

IPC分类号： A61L29/08 ,  A61K31/7024 ,  A61L15/44 ,  A61L27/34 ,  A61L27/54 ,  A61L29/06 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  G01N33/543

CPC分类号： A61L29/085 ,  A61K31/7024 ,  A61L15/44 ,  A61L27/34 ,  A61L27/54 ,  A61L29/06 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  G01N33/54393 ,  A61L2300/216 ,  A61L2300/418 ,  A61L2300/42 ,  A61L2400/04 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/08

摘要： Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.

公开(公告)号：US20190275209A1

公开(公告)日：2019-09-12

申请号：US16272808

申请日：2019-02-11

申请人： Surmodics, Inc.

发明人： David E. Babcock ,  Sean Lundquist ,  Gary Opperman ,  Adriyn Torguson ,  Tim Jentz

IPC分类号： A61L29/08 ,  A61L27/34 ,  A61L29/06 ,  A61K31/7024 ,  G01N33/543 ,  A61L29/16

摘要： Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.