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公开(公告)号：US20200089076A1
公开(公告)日：2020-03-19
申请号：US16496934
申请日：2018-03-22
Applicant: ROCKLEY PHOTONICS LIMITED , UNIVERSITY OF SOUTHAMPTON
Inventor： Guomin YU , Aaron John ZILKIE , Yi ZHANG , David John THOMSON
Abstract: A method of operating an optical modulator. The optical modulator having: a rib waveguide which includes a junction which is either a PIN or PN junction, the junction having a breakdown voltage. The method comprising: applying a reverse bias to the junction, so as to operate the optical modulator around the breakdown voltage of the junction; operating the modulator in an avalanche multiplication and/or band-to-band tunnelling mode by increasing the reverse bias past the breakdown voltage.
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公开(公告)号：US20200060607A1
公开(公告)日：2020-02-27
申请号：US16489219
申请日：2017-03-07
Applicant: University of Southampton
Inventor： Hywel Morgan , Ying Cheong , Nick Macklon , Shilong Lu
Abstract: An intra-uterine monitoring system is described. The system comprises an implantable sensor device, shaped and dimensioned for implantation in a uterus for measuring conditions within the uterus to generate sensor data, and a wearable receiver device, for wirelessly receiving the sensor data generated by the implantable sensor device. In this way, real-time, in-vivo monitoring of the intra-uterine environment can be performed. The implantable sensor device can be kept small and simple, requiring only the mechanical and electronic structures necessary to take sensor measurements and transmit those to the receiver device. By making the receiver device wearable, it can be kept in relatively close proximity to the implantable sensor device on a long-term basis, making regular monitoring viable.
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公开(公告)号：US10571629B1
公开(公告)日：2020-02-25
申请号：US15999071
申请日：2018-08-17
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Harold Chong , Rafidah Petra , Graham Reed , Swe Zin Oo , Antulio Tarazona
Abstract: An integrated photonic device comprising at least a first integrated photonic component supported by a substrate extending substantially in a plane of the device and optically isolating cladding facing the first integrated photonic component, the photonic device further comprising a waveguide formed by a deposited layer of group IV semiconductor material to extend on a slope in a direction out of the plane of the substrate, the waveguide arranged to, in use, couple light from/to the integrated photonic component through the optically isolating cladding.
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公开(公告)号：US10538764B2
公开(公告)日：2020-01-21
申请号：US15619984
申请日：2017-06-12
Applicant: University of Southampton
Inventor： Igor Vorechovsky , Jana Kralovicova
IPC: C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/6883 , C12N15/11
Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
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85.发明申请公开(公告)号：US20200003970A1
公开(公告)日：2020-01-02
申请号：US16023266
申请日：2018-06-29
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Riccardo Marchetti , Cosimo Lacava , Periklis Petropoulos , Paolo Minzioni , Graham T. Reed , Ilaria Cristiani
Abstract: A grating coupler is disclosed. The grating coupler comprises a grating formed in a waveguide formed in a silicon layer of a silicon on insulator photonic component. The grating has a series of sequentially arranged grating elements i, each comprising an alternating etched trench section having a length Le and an etch depth e, and an unetched tooth section having a length L0. Each grating element has a total length of Λi and a fill factor Fi. The fill factor Fi of each grating element varies across the grating coupler according to an apodization function dependent on the location of the grating element. The total length of each grating element Λi varies across the grating coupler such that the effective refractive index of each grating element causes the Bragg condition to be satisfied for all of the grating elements of the grating.
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Patent Agency Ranking
公开(公告)号：US20190250434A1
公开(公告)日：2019-08-15
申请号：US16324748
申请日：2017-08-09
Applicant: University of Southampton
Inventor： Kapil DEBNATH , Graham REED , Shinichi SAITO
IPC: G02F1/025
CPC classification number: G02F1/025 , G02F2001/0152 , G02F2201/063 , G02F2202/105
Abstract: A method of fabricating an optical structure comprises providing a layer of single crystal crystalline silicon supported on an insulating surface of a silicon substrate; using etching to remove part of the silicon layer and define a side wall which is non-parallel to the insulating surface of the substrate; forming a layer of insulating material over the side wall; forming a further layer of silicon over at least the insulating material; and removing the silicon of the further layer to a level of the layer of silicon such that the layer of insulating material occupies a slot between a portion of silicon in the layer and a portion of silicon in the further layer, a thickness of the layer of insulating material defining a width of the slot.
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87.发明授权公开(公告)号：US10359351B2
公开(公告)日：2019-07-23
申请号：US14392103
申请日：2014-04-15
Applicant: University of Southampton
Inventor： Daniel Christopher Spencer , Hywel Morgan
Abstract: A method of electrically measuring the electrical properties of individual particles flowing in a liquid, which method comprises: (i) providing apparatus (3) which is for electrically measuring the individual particles and which has: (a) a fluidic channel (5) for receiving a liquid (6) having the individual particles (4) in suspension in the liquid (6); (b) a first electrode arrangement (8) having at least one measurement electrode (16) and at least one signal electrode (11); and (c) at least one other electrode arrangement (9) having at least one measurement electrode (18) and at least one signal electrode (13); (ii) providing a flow of the liquid (6) through the fluidic channel (5); (iii) applying a first electrical signal through the liquid (6) and along a first conduction path between the measurement electrode (16) and the signal electrode (11) of the first electrode arrangement (8); (iv) applying an electrical signal through the liquid (6) and along at least one other conduction path; (v) comparing the electrical signal between the first and the other conduction paths to generate a comparison signal; (vi) detecting an individual particle passing through the apparatus (3) by detecting a feature of the comparison signal of the individual particle, and obtaining at least one output waveform; (vii) measuring a height-related feature of the output waveform of the individual particle, and generating a first order assessment of the electrical properties of the individual particle; and (viii) assessing the shape of the output waveform to perform a second order adjustment to the first order assessment of the electrical properties of the individual particle, with the second order adjustment utilising data on a perceived degree of error in the first order assessment based on information on a known relationship between the waveform shape and the error in the first order assessment.
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公开(公告)号：US10267720B2
公开(公告)日：2019-04-23
申请号：US14392104
申请日：2014-04-15
Applicant: University of Southampton
Inventor： Daniel Christopher Spencer , Hywel Morgan
Abstract: Apparatus (3) for electrically measuring individual particles (4) flowing in a liquid (6), which apparatus (3) comprises: (i) a fluidic channel (5) for receiving a liquid (6) having the individual particles (4) in suspension in the liquid (6); (ii) a first electrode arrangement (8) having at least one measurement electrode (16) and at least one signal electrode (11); (iii) at least one other electrode arrangement (9) having at least one measurement electrode and at least one signal electrode (13); (iv) at least one signal conditioning electrode (10, 12, 14, 15, 17, 19) positioned adjacent to at least one of the measurement electrodes (16, 18) or at least one of the signal electrode (9); and (v) measuring means (20, 21) for measuring electrical signal changes; and the apparatus (3) being such that: (vi) the first and the other electrode arrangements (8, 9) are connected to the measuring means (20, 21) whereby individual particles passing between the first and other electrode arrangements (8, 9) cause a change in electrical signal which is measured; and (vii) the electrical potential of the signal conditioning electrode (10, 12, 14, 15, 17, 19) is controlled to substantially prevent current flow between the first electrode arrangement (8) and the other electrode arrangement (9).
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公开(公告)号：US10086050B2
公开(公告)日：2018-10-02
申请号：US15120007
申请日：2015-02-19
Applicant: University of Southampton , University of Cape Town
Inventor： Howard William Clark , William Horsnell
Abstract: The present invention relates to Surfactant Protein D (SP-D) or nucleic acids encoding SP-D or variants thereof such as surfactant protein A or mannan binding lectin for use in the treatment and/or prevention of a parasitic infection. Methods for determining the presence of a parasitic infection by determining levels of SP-D in a sample are also disclosed. Also disclosed are helminths for treating allergy, inflammation or infection.
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90.发明申请公开(公告)号：US20180273631A1
公开(公告)日：2018-09-27
申请号：US15934334
申请日：2018-03-23
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Martin John GLENNIE , Alison Louise TUTT , Aymen AL-SHAMKHANI
IPC: C07K16/28 , A61K45/06 , A61K39/395 , A61K39/00
CPC classification number: C07K16/2878 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/2875 , C07K2317/21 , C07K2317/24 , C07K2317/74 , C07K2317/75 , Y02A50/403 , Y02A50/41 , Y02A50/412 , Y02A50/466
Abstract: Methods of inducing T cell proliferation and expansion in vivo for treating conditions wherein antigen-specific T cell immune response are therapeutically desirable such as cancer, infection, inflammation, allergy and autoimmunity and for enhancing the efficacy of vaccines are provided. These methods comprise the administration of at least one CD27 agonist, preferably an agonistic CD27 antibody, alone or in association with another moiety such as immune stimulant or immune modulator such as an anti-CD40, OX-40, 4-1BB, or CTLA-4 antibody or an agent that depletes regulatory cells, or a cytokine. These mono and combination therapies may also optionally include the administration of a desired antigen such as a tumor antigen, an allergen, an autoantigen, or an antigen specific to an infectious agent or pathogen against which a T cell response (often CD8+) is desirably elicited.
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