公开(公告)号：US10772992B2

公开(公告)日：2020-09-15

申请号：US15999308

申请日：2017-02-16

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO ,  UNIVERSITY HEALTH NETWORK

发明人： Paul Santerre ,  Soror Sharifpoor ,  Wey Liang Leong

IPC分类号： A61L27/58 ,  A61L27/18 ,  A61L27/56 ,  A61K9/16

摘要： A soft tissue filler comprising a biodegradable amino-acid derived polycarbonate-urethanes and methods of repairing soft tissue defects are provided. The biodegradable soft tissue filler comprises a porous scaffold that is the reaction product of: a) a divinyl oligomer component that comprises a carbonate-derived divinyl oligomer that is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and a polycarbonate and, optionally, an ether-derived divinyl oligomer, wherein the ether-derived divinyl oligomer is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and an ether; b) at least one anionic monomer; and c) at least one hydrophobic monomer. The molar ratio of (a):(b+c) is between about 1:≥21 and about 1:30, the soft tissue filler has a porosity of >75%; and a compressive moduli of between about 1 kPa and about 50 kPa.

公开(公告)号：US10772928B2

公开(公告)日：2020-09-15

申请号：US15536416

申请日：2015-12-15

申请人： The Governing Council of the University of Toronto ,  Sinai Health System

发明人： Benjamin J. Blencowe ,  Mathieu Quesnel-Vallieres ,  Manuel Irimia ,  Bushra Raj ,  Sabine P. Cordes

IPC分类号： A61K38/55 ,  A61K38/05 ,  A61K31/7088 ,  G01N33/68 ,  C12Q1/6883 ,  A61K38/46 ,  G01N33/50 ,  A01K67/027 ,  C07K14/47 ,  A61K45/06 ,  A61K31/713 ,  A61K49/00

摘要： Methods for treatment and diagnosis of neurological disorders such as autism and autism spectrum disorder are disclosed. Also disclosed are modulators of alternative splicing regulators SRRM4 and/or SRRM3 for treating neurological disorders. Further disclosed are agents that modulate the expression of at least one splice variant for treating neurological disorders. Mouse models of neurological disorders having increased or decreased expression of SRRM4 and/or SRRM3 are also disclosed.

公开(公告)号：US20200270218A1

公开(公告)日：2020-08-27

申请号：US16652733

申请日：2018-10-01

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： Patrick Thomas Gunning ,  Dzlyana Kraskouskaya ,  Aaron Cabral ,  Bronte Murcar-Evans ,  Krlmo Toutah ,  Elvln De Araujo

IPC分类号： C07D257/02 ,  C07C233/44 ,  C07C309/65 ,  C07D213/38 ,  G01N21/64

摘要： This application relates to a method of detecting negatively charged phosphate-containing membranes and membrane components, such as in cell membranes or artificial lipid vesicles, and its use, for example, in detecting apoptosis and bacterial infection.

公开(公告)号：US10746743B2

公开(公告)日：2020-08-18

申请号：US15344971

申请日：2016-11-07

申请人： The Governing Council of the University of Toronto

发明人： Sachdev Sidhu ,  Jason Moffat ,  Helena Persson ,  Nish Patel ,  Saravanan Sundararajan ,  Amandeep Gakhal ,  Wei Ye ,  Jelena Tomic ,  Megan Elizabeth Mclaughlin

IPC分类号： C40B30/04 ,  G01N33/68 ,  C12N15/10

摘要： There is provided herein a method for identifying and/or recovering at least one genetically encoded affinity reagent specific for a target molecule by screening using molecular display in conjunction with the sequencing of positive and negative selection pools from the screen.

公开(公告)号：US10725033B2

公开(公告)日：2020-07-28

申请号：US15802120

申请日：2017-11-02

申请人： Regents of the University of Minnesota ,  The Governing Council of the University of Toronto

发明人： John C. Bischof ,  Zhenpeng Qin ,  Warren Chan ,  Taner Akkin ,  Li Zhan

IPC分类号： G01N33/543 ,  G01N33/558 ,  G01N33/569 ,  G01N33/76 ,  G01N25/48 ,  G01N21/77 ,  G01N21/17

摘要： Assays used in conjunction with a thermal contrast reader are disclosed. In the assay, the test strip includes materials that can develop a thermal response if a target analyte is present in a sample. Linear flow assays include nanoparticles with high affinity binding to the analyte. Binding of the nanoparticles with an analyte in the sample is detected using thermal contrast. Analytes over a broad range of concentrations are detected in the linear flow assays. Methods of detecting target analytes and kits comprising lateral flow assays and thermal contrast reader are also disclosed.

公开(公告)号：US10715309B2

公开(公告)日：2020-07-14

申请号：US16365463

申请日：2019-03-26

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： Alhassan Khedr ,  Glenn Gulak

IPC分类号： H04L9/00 ,  H04L9/06 ,  G09C1/00 ,  G06F9/30 ,  G06F7/50

摘要： Fully homomorphic encryption integrated circuit (IC) chips, systems and associated methods are disclosed. In one embodiment, a method of operation for a number theoretic transform (NTT) butterfly circuit is disclosed. The (NTT) butterfly circuit includes a high input word path cross-coupled with a low word path. The high input word path includes a first adder/subtractor, and a first multiplier. The low input word path includes a second adder/subtractor, and a second multiplier. The method includes selectively bypassing the second adder/subtractor and the second multiplier, and reconfiguring the low and high input word paths into different logic processing units in response to different mode control signals.

公开(公告)号：US10707679B2

公开(公告)日：2020-07-07

申请号：US16010187

申请日：2018-06-15

申请人： Peter Waldemar Lehn ,  Kyle Muehlegg ,  The Governing Council of the University of Toronto

发明人： Peter Waldemar Lehn ,  Kyle Muehlegg

IPC分类号： H02J1/10 ,  H02J7/00 ,  H02J3/38 ,  H02J1/14 ,  H02J3/32 ,  H02J7/35

摘要： An improved method for sharing power between multiple battery energy storage systems (BESS) connected to a common DC network having a nominal voltage wherein the current from each BESS is regulated based upon a voltage-current characteristic which defines an output current which increases linearly in a predetermined ratio as the measured system voltage decreases. The predetermined ratio is constant in respect of each BESS. The output current of each BESS varies based upon an external signal that varies with the state of charge of the BESS.

公开(公告)号：US20200179532A1

公开(公告)日：2020-06-11

申请号：US16636141

申请日：2018-08-03

申请人： The Hospital for Sick Children ,  The Governing Council of the University of Toronto

发明人： Jean-Philippe Julien ,  Taylor Sicard ,  Anthony Semesi ,  Bebhinn Treanor ,  Tiantian Zhao ,  Edurne Rujas Diez

IPC分类号： A61K47/69 ,  A61K39/015 ,  A61K47/68 ,  C07K14/445

摘要： A fusion protein comprises a nanocage monomer; and an antibody or fragment thereof linked to the nanocage monomer, the antibody or fragment thereof comprising a first member of a binding pair; wherein a plurality of the fusion proteins self-assemble to form a nanocage in which a plurality of the antibodies or fragments thereof decorate the exterior surface of the nanocage, whereby the first member of the binding pair is exposed for interacting with a second member of a binding pair.

公开(公告)号：US20200080064A1

公开(公告)日：2020-03-12

申请号：US15741484

申请日：2016-07-04

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： Alexander Yakunin ,  Anna Khusnutdinova ,  Jeong Chan Joo ,  Radhakrishnan Mahadevan

IPC分类号： C12N9/02 ,  C12N15/70 ,  C12P7/18 ,  C12P13/00 ,  C12P7/42 ,  C12P7/44 ,  C12P7/24

摘要： A method for biosynthesis of polymer precursors, including, adipic acid, 1,6-hexanediol, 6-hydroxyhexanoic and 6-aminocaproic acids from carboxylic acids is provided. A method for biosynthesis of adipic acid from six-carbon dicarboxylic acids having α, β-enoate reductase activity by treatment with an enzyme is provided. The biocatalytic conversion of aliphatic and hydroxycarboxylic acids to corresponding aldehydes, alcohols, and amines using novel carboxylate reductases, aldehyde reductases, and aminotransferases is described. Also provided are genetically engineered microorganisms for use in the biosynthetic processes.

公开(公告)号：US20200064359A1

公开(公告)日：2020-02-27

申请号：US16598361

申请日：2019-10-10

申请人： Roche Diagnostics Operations, Inc. ,  The Governing Council of the University of Toronto

发明人： Ursula-Henrike Wienhues-Thelen ,  Georg Hess ,  Hendrik Huedig ,  Herbert von der Eltz ,  Andrew Emili ,  Anthony Gramolini ,  Peter Liu ,  David MacLennan ,  Vincent Fong ,  Ruth Isserlin ,  Thomas Kislinger ,  Dirk Block

IPC分类号： G01N33/68

摘要： Disclosed is a method for assessing heart failure in vitro including the steps of measuring in a sample the concentration of the marker IGFBP-7, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for IGFBP-7 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of IGFBP-7 as a marker protein in the assessment of heart failure, a marker combination comprising IGFBP-7 and a kit for measuring IGFBP-7.