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公开(公告)号：US12227737B2
公开(公告)日：2025-02-18
申请号：US18061273
申请日：2022-12-02
Applicant: University Health Network , Sinai Health System
Inventor： Daniel Diniz De Carvalho , Shu Yi Shen , Rajat Singhania , Scott Victor Bratman , Ankur Ravinarayana Chakravarthy
IPC: C12N15/10 , C12Q1/6804 , C12Q1/6806 , C12Q1/6886 , C40B30/04 , G01N33/53
Abstract: There is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.
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公开(公告)号：US20240280589A1
公开(公告)日：2024-08-22
申请号：US18391104
申请日：2023-12-20
Applicant: Sinai Health System , The Hospital for Sick Children
Inventor： Isabella Caniggia , Martin Post , Sruthi Alahari
IPC: G01N33/68
CPC classification number: G01N33/689 , G01N2333/78 , G01N2333/90245 , G01N2800/368
Abstract: A method and kit for predicting preeclampsia is provided. Levels of Jumonji C domain containing protein 6 (JMJD6) and fibronectin are measured in placenta-derived small extracellular vesicles isolated from a subject. The levels of JMJD6 and fibronectin are compared to a non-preeclamptic control. If levels of JMJD6 are depressed and levels of fibronectin are elevated, the subject may be monitored or treated for preeclampsia.
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公开(公告)号：US20240207300A1
公开(公告)日：2024-06-27
申请号：US18284614
申请日：2022-04-07
Applicant: Repare Therapeutics Inc. , Sinai Health System
Inventor： Jimmy FOURTOUNIS , Jordan YOUNG , Cynthia BERNIER , Daniel DUROCHER , Nicole HUSTEDT
IPC: A61K31/7068 , A61K31/437 , A61K31/4745 , A61K31/4985 , A61K31/5377 , A61K31/555 , A61K45/06 , A61P35/00
CPC classification number: A61K31/7068 , A61K31/437 , A61K31/4745 , A61K31/4985 , A61K31/5377 , A61K31/555 , A61K45/06 , A61P35/00
Abstract: The use of inhibitors of tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1) in the treatment of cancer is disclosed. In preferred embodiments, the Myt1 inhibitor is a carboxamide pyrrolopyrazine or carboxamide pyrrolopyridine of Formula I. The Myt1 inhibitors may be used in combination with a variety of other anti-cancer agents. Such agents include a WEE1 inhibitor, TOPI or TOP2A inhibitor, RRM1 or RRM2 inhibitor, AURKA or AURKB inhibitor, ATR inhibitor, TTK inhibitor, SOD1 or SOD2 inhibitor, BUB1 inhibitor, CDC7 inhibitor, SAE1 inhibitor, PLK1 inhibitor, UBA2 inhibitor, DUT inhibitor, HDAC3 inhibitor, CHEK1 inhibitor, MEN1 inhibitor, DOT1L inhibitor, CREBBP inhibitor, EZH2 inhibitor, PLK4 inhibitor, HASPIN inhibitor, METTL3 inhibitor, nucleoside analogs, and platinum-based DNA alkylating agents.
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4.发明公开公开(公告)号：US20240025887A1
公开(公告)日：2024-01-25
申请号：US18271089
申请日：2022-01-07
Applicant: Ontario Institute for Cancer Research (OICR) , The Governing Council of The University of Toronto , Sinai Health System
Inventor： Rima Al-Awar , Liliana Attisano , Methvin Isaac , Yong Liu , David Smil , David Uehling , Jeff Wrana
IPC: C07D409/12 , C07D487/08 , C07D409/14 , C07D498/04 , C07D471/10 , C07D487/04 , C07D239/48
CPC classification number: C07D409/12 , C07D487/08 , C07D409/14 , C07D498/04 , C07D471/10 , C07D487/04 , C07D239/48
Abstract: The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting or blocking NUAK kinase, such as cancers and fibrosis.
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公开(公告)号：US20230203473A1
公开(公告)日：2023-06-29
申请号：US18061273
申请日：2022-12-02
Applicant: University Health Network , Sinai Health System
Inventor： Daniel DINIZ DE CARVALHO , Shu Yi SHEN , Rajat SINGHANIA , Scott Victor BRATMAN , Ankur RAVINARAYANA CHAKRAVARTHY
IPC: C12N15/10 , C12Q1/6806 , C12Q1/6804 , G01N33/53
CPC classification number: C12N15/1003 , C12N15/1093 , C12N15/10 , C12Q1/6806 , C12Q1/6804 , G01N33/5308 , C12Q1/6886
Abstract: There is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.
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Patent Agency Ranking
公开(公告)号：US11560558B2
公开(公告)日：2023-01-24
申请号：US17519350
申请日：2021-11-04
Applicant: University Health Network , Sinai Health System
Inventor： Daniel Diniz De Carvalho , Shu Yi Shen , Rajat Singhania
IPC: C12N15/10 , C12Q1/6806 , C12Q1/6804 , G01N33/53 , C12Q1/6886 , C40B30/04
Abstract: There is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.
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公开(公告)号：US20220325289A1
公开(公告)日：2022-10-13
申请号：US17825784
申请日：2022-05-26
Applicant: Sinai Health System
Inventor： Andras NAGY , Claudio MONETTI , Qin LIANG
Abstract: The present disclosure provides molecular tools, methods and kits for using cell division loci (CDLs) to control cell proliferation in animal cells. CDLs, as provided herein, are loci whose transcription product(s) are expressed during cell division. CDLs may be genetically modified, as described herein, to comprise a negative selectable marker and/or an inducible activator-based gene expression system, which allows a user to permit, ablate, and/or inhibit proliferation of the genetically modified cell(s) by adding or removing an appropriate inducer.
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公开(公告)号：US20220251665A1
公开(公告)日：2022-08-11
申请号：US17668314
申请日：2022-02-09
Applicant: UNIVERSITY HEALTH NETWORK , SINAI HEALTH SYSTEM
Inventor： Daniel DINIZ DE CARVALHO , Scott Victor BRATMAN , Rajat SINGHANIA , Ankur RAVINARAYANA CHAKRAVARTHY , Shu Yi SHEN
IPC: C12Q1/6886 , C12Q1/6827
Abstract: There is described herein a method of detecting the presence of DNA from cancer cells in a subject comprising: providing a sample of cell-free DNA from a subject; subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated, then optionally denaturing the sample; capturing cell-free methylated DNA using a binder selective for methylated polynucleotides; sequencing the captured cell-free methylated DNA; comparing the sequences of the captured cell-free methylated DNA to control cell-free methylated DNAs sequences from healthy and cancerous individuals and from individuals with distinct cancer types and subtypes; identifying the presence of DNA from cancer cells if there is a statistically significant similarity between one or more sequences of the captured cell-free methylated DNA and cell-free methylated DNAs sequences from cancerous individuals.
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公开(公告)号：US11261466B2
公开(公告)日：2022-03-01
申请号：US15554042
申请日：2016-03-01
Applicant: Sinai Health System
Inventor： Daniel Durocher , Alexandre Orthwein , Sylvie Noordermeer
IPC: C12N15/00 , C12N15/09 , C12N15/113 , C07K14/47 , C12N15/90 , A61K31/713 , C12N15/10 , C12Q1/6886 , C12N15/63 , C12N9/00 , C12N15/67
Abstract: The invention relates to factors that influence or regulate homologous recombination, methods to monitor these factors, the use of these factors to screen for agents that modulate homologous recombination, and methods to activate or modulate homologous recombination.
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公开(公告)号：US10808017B2
公开(公告)日：2020-10-20
申请号：US16073501
申请日：2017-01-31
Inventor： Daniel Durocher , Sachdev Sidhu , Wei Zhang , Frank Sicheri , Marella Canny
Abstract: 53BP1 inhibitors, compositions comprising the inhibitors and methods of using same are provided. The inhibitors can be used in combination with gene editing systems.
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