公开(公告)号：US20100153568A1

公开(公告)日：2010-06-17

申请号：US12336000

申请日：2008-12-16

Applicant: Juha Uola ,  Raine Makelainen ,  Yan Fu

Inventor： Juha Uola ,  Raine Makelainen ,  Yan Fu

IPC: G06F15/173

CPC classification number: H04L67/02

Abstract: A method, apparatus, and computer program product are provided for providing a local proxy for accessing web services. An apparatus may include a processor configured to receive, at a proxy service implemented on the apparatus, a first HTTP request from a HTTP protocol client application executed on the apparatus. The first HTTP request may be directed to a first network location, wherein the HTTP client application is associated with the first network location. The processor may be further configured to determine whether the first HTTP request includes an indication of a second network location for circumventing a same-origin policy. The processor may additionally be configured to transmit a second HTTP request to the second network location when the first HTTP request includes an indication of a second network location. Corresponding methods and computer program products are also provided.

Abstract translation: 提供了一种方法，装置和计算机程序产品，用于提供用于访问web服务的本地代理。 设备可以包括处理器，其被配置为在设备上实现的代理服务处接收来自在该设备上执行的HTTP协议客户端应用的第一HTTP请求。 第一HTTP请求可以被引导到第一网络位置，其中HTTP客户端应用与第一网络位置相关联。 处理器还可以被配置为确定第一HTTP请求是否包括用于规避同源策略的第二网络位置的指示。 当第一HTTP请求包括第二网络位置的指示时，处理器还可被配置为向第二网络位置发送第二HTTP请求。 还提供了相应的方法和计算机程序产品。

公开(公告)号：US20100068173A1

公开(公告)日：2010-03-18

申请号：US12203116

申请日：2008-09-02

Applicant: Zailin Yu ,  Yan Fu

Inventor： Zailin Yu ,  Yan Fu

IPC: A61K38/20 ,  C07K14/54 ,  C07H21/00 ,  C12N15/63 ,  C12N5/00 ,  C12N5/07 ,  C12N5/04 ,  C12N1/19 ,  C12N1/21 ,  A61P43/00

CPC classification number: A61K38/38 ,  A61K47/643 ,  A61K47/646 ,  C07H21/04 ,  C07K14/47 ,  C07K14/475 ,  C07K14/505 ,  C07K14/52 ,  C07K14/54 ,  C07K14/5403 ,  C07K14/5431 ,  C07K14/765 ,  C07K14/79 ,  C07K2319/00 ,  Y02A50/463 ,  A61K2300/00

Abstract: Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and bioactive molecules. The bioactive molecules may be a protein or peptide having a biological function in vitro or in vivo, and preferably, having a therapeutic activity when administered to a human. By fusing the bioactive molecule to HSA, stability of the bioactive molecule in vivo can be improved and the therapeutic index increased due to reduced toxicity and longer-lasting therapeutic effects in vivo. In addition, manufacturing processes are provided for efficient, cost-effective production of these recombinant proteins in yeast.

Abstract translation: 提供了通过使用人血清白蛋白（HSA）和生物活性分子的新型重组融合蛋白来促进一般健康或预防或治疗疾病的组合物，试剂盒和方法。 生物活性分子可以是在体外或体内具有生物学功能的蛋白质或肽，并且优选地，当施用于人时具有治疗活性。 通过将生物活性分子融合到HSA中，可以改善体内生物活性分子的稳定性，并且由于体内毒性降低和持久的治疗效果，治疗指数增加。 此外，提供制造方法用于在酵母中有效，成本有效地生产这些重组蛋白。

公开(公告)号：US20080009446A1

公开(公告)日：2008-01-10

申请号：US11825686

申请日：2007-07-08

Applicant: Zailin Yu ,  Yan Fu

Inventor： Zailin Yu ,  Yan Fu

IPC: A61K38/17 ,  C07H21/04 ,  C07K14/00 ,  C07K14/765 ,  C12N1/16 ,  C12N1/20 ,  C12N15/63 ,  C12N5/04 ,  C12N5/06

CPC classification number: A61K38/38 ,  A61K47/643 ,  A61K47/646 ,  C07H21/04 ,  C07K14/47 ,  C07K14/475 ,  C07K14/505 ,  C07K14/52 ,  C07K14/54 ,  C07K14/5403 ,  C07K14/5431 ,  C07K14/765 ,  C07K14/79 ,  C07K2319/00 ,  Y02A50/463 ,  A61K2300/00

Abstract: Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and bioactive molecules. The bioactive molecules may be a protein or peptide having a biological function in vitro or in vivo, and preferably, having a therapeutic activity when administered to a human. By fusing the bioactive molecule to HSA, stability of the bioactive molecule in vivo can be improved and the therapeutic index increased due to reduced toxicity and longer-lasting therapeutic effects in vivo. In addition, manufacturing processes are provided for efficient, cost-effective production of these recombinant proteins in yeast.

Abstract translation: 提供了通过使用人血清白蛋白（HSA）和生物活性分子的新型重组融合蛋白来促进一般健康或预防或治疗疾病的组合物，试剂盒和方法。 生物活性分子可以是在体外或体内具有生物学功能的蛋白质或肽，并且优选地，当施用于人时具有治疗活性。 通过将生物活性分子融合到HSA中，可以改善体内生物活性分子的稳定性，并且由于体内毒性降低和持久的治疗效果，治疗指数增加。 此外，提供制造方法用于在酵母中有效，成本有效地生产这些重组蛋白。

公开(公告)号：US5447564A

公开(公告)日：1995-09-05

申请号：US197270

申请日：1994-02-16

Applicant: Ping Xie ,  Ping Gu ,  Yan Fu ,  James J. Beaudoin

Inventor： Ping Xie ,  Ping Gu ,  Yan Fu ,  James J. Beaudoin

IPC: C04B28/02 ,  C04B40/00 ,  C04B14/48

CPC classification number: C04B28/02 ,  C04B40/0028 ,  C04B2111/94

Abstract: Conductive cement-based compositions exhibiting both good electrical conductivity and mechanical strength have been obtained by ensuring proper dispersion of conductive phase within the composition. The content of the ingredients depends on the preparation method, for instance conventional mixing or slurry infiltration, and on the type of the composition, i.e. conductive paste, mortar or concrete. The broad content ranges of the conductive composition are:a cement binder,a conductive phase consisting of one or more of the following:conductive fibers in the amount from 0 to 15% by volume of the composition;conductive particles in the amount from 0 to 80% by volume of the composition;water, at the weight ratio relative to cement binder from 0.2 to 0.75,fine agregates at the weight ratio relative to cement binder from 0.0 to 2.0, andcoarse aggregates at the weight ratio relative to cement binder from 0.0 to 2.0,conventional additives or admixtures, and optionally a dispersant.Exemplary compositions obtained according to the invention have a 28-day d.c. resistivity of 0.46-43 .OMEGA.cm and 28-day compressive strength of 35-71 MPa.

Abstract translation: 通过确保导电相在组合物内的适当分散，已经获得了具有良好导电性和机械强度的导电性水泥基组合物。 成分的含量取决于制备方法，例如常规混合或浆料渗透，以及组合物的类型，即导电浆料，砂浆或混凝土。 导电组合物的宽范围的范围是：水泥粘合剂，由以下一种或多种组成的导电相：组合物的0至15体积％的导电纤维; 量为组合物体积的0至80％的导电颗粒; 水相对于水泥粘合剂的重量比为0.2-0.75，相对于水泥粘合剂的重量比为0.0〜2.0的细小的凝聚体，相对于水泥粘合剂的重量比为0.0〜2.0的粗骨料，常规的添加剂或混合物 ，和任选的分散剂。 根据本发明获得的示例性组合物具有28天直径 电阻率为0.46-43欧米伽厘米，28天抗压强度为35-71兆帕。