Patent search ap:("AbbVie Page Inc.") AND inv:"Andrew J. Souers"

81.

发明授权
BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases 有权
Title translation: 用于治疗癌症和免疫疾病的BCL-2选择性细胞凋亡诱导剂

公开(公告)号：US09072748B2

公开(公告)日：2015-07-07

申请号：US14058164

申请日：2013-10-18

Applicant: AbbVie Inc.

Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura A. Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt

IPC: C07D405/06 , C07D413/06 , C07D487/04 , C07D241/04 , C07D401/06 , A61K31/5377 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D471/04 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K45/06 , C07D403/06

CPC classification number: C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。

82.

发明授权
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases 有权

公开(公告)号：US09034875B2

公开(公告)日：2015-05-19

申请号：US13831184

申请日：2013-03-14

Applicant: AbbVie Inc.

Inventor： George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Andrew J. Souers , Zhi-Fu Tao , Gary T. Wang , Le Wang , Robert Mantei , Todd M. Hansen

IPC: A61K31/407 , C07D401/12 , C07D471/04 , C07D491/052 , C07D519/00

CPC classification number: C07D471/04 , C07D491/052 , C07D519/00

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

83.

发明授权
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases 有权

公开(公告)号：US09029404B2

公开(公告)日：2015-05-12

申请号：US14053544

申请日：2013-10-14

Applicant: AbbVie Inc.

Inventor： George A. Doherty , Steven W. Elmore , Laura A. Hexamer , Robert A. Mantei , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen

IPC: A61K31/404 , A61K31/416 , C07D403/14 , C07D413/14 , C07D213/76 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D211/06 , C07D295/14 , C07D309/32 , C07D403/12

CPC classification number: C07D213/76 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/06 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/14 , C07D295/30 , C07D309/04 , C07D309/32 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

84.

发明申请
CDK9 KINASE INHIBITORS 有权
Title translation: CDK9激酶抑制剂

公开(公告)号：US20140275153A1

公开(公告)日：2014-09-18

申请号：US14207841

申请日：2014-03-13

Applicant: AbbVie Inc.

Inventor： Chunqiu Lai , Zhi-Fu Tao , Keith W. Woods , Thomas D. Penning , Andrew J. Souers , Anthony Mastracchio , Julie M. Miyashiro , Yunsong Tong

IPC: C07D471/04 , A61K31/437 , C07D519/00

CPC classification number: C07D471/04 , A61K31/437 , A61K31/519 , A61K45/06 , C07D487/04 , C07D519/00

Abstract: Disclosed are compound of Formula (Ia), wherein R1A, R1, R2, R10, J, L, T, X, Y, and Z are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions, comprising one or more compounds of Formula (Ia).

Abstract translation: 公开了式（Ia）的化合物，其中R 1A，R 1，R 2，R 10，J，L，T，X，Y和Z如说明书中所定义，及其药学上可接受的盐。这些化合物可以用作治疗包括癌症在内的疾病的药剂。还提供了包含一种或多种式（Ia）化合物的药物组合物。

85.

发明申请
PYRROLO[2,3-B]PYRIDINE CDK9 KINASE INHIBITORS 有权
Title translation: 吡咯并[2,3-B]吡啶CDK9激酶抑制剂

公开(公告)号：US20140275027A1

公开(公告)日：2014-09-18

申请号：US14207886

申请日：2014-03-13

Applicant: AbbVie Inc.

Inventor： Jianchun Gong , Zhi-Fu Tao , Thomas D. Penning , Andrew J. Souers , Yunsong Tong , Guidong Zhu

IPC: C07D471/04 , A61K31/5377 , A61K31/497 , A61K31/437

CPC classification number: C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K45/06 , A61K2300/00

Abstract: Disclosed are compounds of Formula (IIIa), wherein R1, R2, R3, X1, X2, X3, X4, X5, have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIIa).

Abstract translation: 公开了式（IIIa）的化合物，其中R 1，R 2，R 3，X 1，X 2，X 3，X 4，X 5具有本说明书中定义的任何值及其药学上可接受的盐。这些化合物可以用作治疗包括癌症在内的疾病的药剂。还提供了包含一种或多种式（IIIa）化合物的药物组合物。

86.

发明申请
PYRIDINE CDK9 KINASE INHIBITORS 有权
Title translation: 吡啶CDK9激酶抑制剂

公开(公告)号：US20140275011A1

公开(公告)日：2014-09-18

申请号：US14207854

申请日：2014-03-13

Applicant: AbbVie Inc.

Inventor： Anthony Mastracchio , Milan Bruncko , Chunqiu Lai , Julie M. Miyashiro , Zhi-Fu Tao , Keith W. Woods , Thomas D. Penning , Andrew J. Souers

IPC: C07D401/04 , A61K31/4545 , C07D405/14 , A61K31/4439 , A61K31/439 , C07D409/14 , C07D417/14 , A61K31/444 , A61K31/506 , C07D453/02 , C07D401/14 , A61K31/5377

CPC classification number: C07D401/04 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/5377 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D453/02 , C07D471/04

Abstract: Disclosed are compound of Formula (Ia), wherein R2, R12, R16, J, Q, X, Y and Z are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (Ia).

Abstract translation: 公开了式（Ia）的化合物，其中R 2，R 12，R 16，J，Q，X，Y和Z如说明书中所定义，及其药学上可接受的盐。这些化合物可以用作治疗包括癌症在内的疾病的药剂。还提供了包含一种或多种式（Ia）化合物的药物组合物。