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公开(公告)号：US20090054828A1
公开(公告)日：2009-02-26
申请号：US11895026
申请日：2007-08-22
CPC分类号： A61N1/3962 , A61B5/046 , A61B5/0464 , A61N5/0601 , A61N5/062 , A61N2005/0651
摘要： The invention provides a system coupled to a heart having a right atrium (RA) and an atrioventricular (AV) node, which includes an implantable gene regulatory signal delivery device configured to deliver a light to a target site in the heart to transiently control an aberrant cardiac electrical conduction, the light having characteristics suitable for regulating a transcription control element; and an implantable medical device communicatively coupled to the implantable gene regulatory signal delivery device, the implantable medical device including: an atrial fibrillation (AF) detector configured to detect AF; and a control circuit configured to initiate an emission of the light from the implantable gene regulatory signal delivery device in response to the detection of AF. Also provided are methods to transiently control aberrant AV conduction or transiently control cardiac arrhythmias, which employ expression cassettes.
摘要翻译： 本发明提供一种耦合到具有右心房（RA）和房室（AV））节点的心脏的系统，其包括可植入的基因调节信号传递装置，其被配置为将光传递到心脏中的目标部位以暂时控制异常 心电传导，光具有适于调节转录控制元件的特征; 以及通信地耦合到所述可植入基因调节信号传递装置的可植入医疗装置，所述可植入医疗装置包括：构造成检测AF的心房颤动（AF）检测器; 以及控制电路，其被配置为响应于AF的检测而启动来自所述可植入基因调节信号传递装置的光的发射。 还提供了瞬时控制异常AV传导或瞬时控制使用表达盒的心律失常的方法。
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公开(公告)号：US20080319513A1
公开(公告)日：2008-12-25
申请号：US11767901
申请日：2007-06-25
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/0816 , A61B5/4035 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36117
摘要： A system embodiment comprises at least one respiration sensor, a neural stimulation therapy delivery module, and a controller. The respiration sensor is adapted for use in monitoring respiration of the patient. The neural stimulation therapy delivery module is adapted to generate a neural stimulation signal for use in stimulating the autonomic neural target of the patient for the chronic neural stimulation therapy. The controller is adapted to receive a respiration signal from the at least one respiration sensor indicative of the patient's respiration, and adapted to control the neural stimulation therapy delivery module using a respiratory variability measurement derived using the respiration signal.
摘要翻译： 系统实施例包括至少一个呼吸传感器，神经刺激治疗传递模块和控制器。 呼吸传感器适用于监测患者的呼吸。 神经刺激治疗递送模块适于产生用于刺激患者的自主神经靶标用于慢性神经刺激治疗的神经刺激信号。 控制器适于接收来自指示患者呼吸的至少一个呼吸传感器的呼吸信号，并且适于使用使用呼吸信号导出的呼吸变异性测量来控制神经刺激治疗递送模块。
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公开(公告)号：US07437191B2
公开(公告)日：2008-10-14
申请号：US11458286
申请日：2006-07-18
申请人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. R. Vanagt
发明人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. R. Vanagt
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了以提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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公开(公告)号：US20080004669A1
公开(公告)日：2008-01-03
申请号：US11427517
申请日：2006-06-29
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/37 , A61N1/371 , A61N1/3712
摘要： A method and apparatus is described for preventing or reducing the ventricular remodeling that normally occurs after a myocardial infarction using pacing therapy. By pacing sites in proximity to the infarct with appropriately timed pacing pulses, the infarct region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the stimulus for remodeling. If capture by the pacing pulses is not being achieved, the device may be configured to change the pacing pulse energy and/or pacing site as appropriate.
摘要翻译： 描述了一种用于预防或减少通常在使用起搏治疗的心肌梗塞后发生的心室重塑的方法和装置。 通过用适当的定时起搏脉冲对位于梗塞范围附近的部位进行起搏，梗塞区域以减轻其受到的机械应力的方式预激发，从而减少重塑的刺激。 如果没有实现通过起搏脉冲的捕获，则该装置可以被配置为适当地改变起搏脉冲能量和/或起搏部位。
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公开(公告)号：US07295874B2
公开(公告)日：2007-11-13
申请号：US11030575
申请日：2005-01-06
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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公开(公告)号：US07065405B2
公开(公告)日：2006-06-20
申请号：US10298156
申请日：2002-11-15
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： An apparatus and method preventing cardiac arrhythmias with pacing therapy is disclosed. Upon detection of a pre-arrhythmic condition, an implantable cardiac rhythm management device is configured to deliver pacing therapy in a manner that pre-excites particular myocardial sites that have been identified as stressed sites and likely locations for the origination of arrhythmias. Such pacing results in a reduction in myocardial wall stress at those sites during systole and reduces the probability of an arrhythmia occurring.
摘要翻译： 公开了一种通过起搏治疗预防心律失常的装置和方法。 在检测到心律前症状之后，植入式心律管理装置被配置为以预先激励已经被识别为应激位点的特定心肌部位并且可能发生心律失常的位置的方式来递送起搏治疗。 这种起搏导致收缩期间那些部位的心肌壁应力减少，并降低发生心律失常的可能性。
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公开(公告)号：US09295845B2
公开(公告)日：2016-03-29
申请号：US11427517
申请日：2006-06-29
CPC分类号： A61N1/3627 , A61N1/37 , A61N1/371 , A61N1/3712
摘要： A method and apparatus is described for preventing or reducing the ventricular remodeling that normally occurs after a myocardial infarction using pacing therapy. By pacing sites in proximity to the infarct with appropriately timed pacing pulses, the infarct region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the stimulus for remodeling. If capture by the pacing pulses is not being achieved, the device may be configured to change the pacing pulse energy and/or pacing site as appropriate.
摘要翻译： 描述了一种用于预防或减少通常在使用起搏治疗的心肌梗塞后发生的心室重塑的方法和装置。 通过用适当的定时起搏脉冲对位于梗塞范围附近的部位进行起搏，梗塞区域以减轻其受到的机械应力的方式预激发，从而减少重塑的刺激。 如果没有实现通过起搏脉冲的捕获，则该装置可以被配置为适当地改变起搏脉冲能量和/或起搏部位。
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公开(公告)号：US08983598B2
公开(公告)日：2015-03-17
申请号：US11538488
申请日：2006-10-04
申请人： Imad Libbus , Joseph M. Pastore
发明人： Imad Libbus , Joseph M. Pastore
CPC分类号： A61N1/36114 , A61N1/0504 , A61N1/3956
摘要： According to an embodiment of a method, a predetermined cardiac activity indicated for an antitachycardia shock is detected. Neural stimulation is applied to lower a defibrillation threshold in preparation for the shock, and the shock is subcutaneously delivered. According to one embodiment, neural stimulation is applied as part of a prophylactic therapy. A predetermined cardiac activity indicated for an antitachycardia shock is detected, and the shock is subcutaneously delivered. Other aspects and embodiments are provided herein.
摘要翻译： 根据方法的一个实施方案，检测到针对抗心动过速休克指示的预定心脏活动。 应用神经刺激来降低除颤阈值以准备休克，并且皮下递送休克。 根据一个实施例，神经刺激作为预防性治疗的一部分被应用。 检测到针对抗心动过速休克的预定心脏活动，并且皮下递送休克。 本文提供了其它方面和实施例。
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89.发明授权Dynamic device therapy control for treating post myocardial infarction patients 有权用于治疗心肌梗死后患者的动态装置治疗控制公开(公告)号：US08504155B2
公开(公告)日：2013-08-06
申请号：US12942471
申请日：2010-11-09
申请人： Yinghong Yu , Jiang Ding , Joseph M. Pastore
发明人： Yinghong Yu , Jiang Ding , Joseph M. Pastore
IPC分类号： A61N1/365
CPC分类号： A61N1/365
摘要： A cardiac rhythm management system includes an implantable device executing a dynamic pacing algorithm after an myocardial infarction (MI) event. The dynamic pacing algorithm dynamically adjusts one or more pacing parameters based on a person's gross physical activity level. Examples of the one or more pacing parameters include atrioventricular pacing delays and pacing channels/sites. The dynamic pacing algorithm provides for improved hemodynamic performance when a person's metabolic need is high, and post MI remodeling control when the person's metabolic need is low.
摘要翻译： 心律管理系统包括在心肌梗死（MI）事件之后执行动态起搏算法的可植入装置。 动态起搏算法根据人的总身体活动水平动态调整一个或多个起搏参数。 一个或多个起搏参数的示例包括房室起搏延迟和起搏通道/部位。 当人的代谢需求高时，动态起搏算法提供改善的血液动力学性能，并且当人的代谢需求低时，进行后重建控制。
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公开(公告)号：US07979123B2
公开(公告)日：2011-07-12
申请号：US11868767
申请日：2007-10-08
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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