公开(公告)号：US20110182400A1

公开(公告)日：2011-07-28

申请号：US13120660

申请日：2009-10-05

申请人： Peter Forthmann ,  Thomas Koehler ,  Udo Van Stevendaal ,  Matthias Bertram ,  Steffen Wiesner ,  Colas Schretter

发明人： Peter Forthmann ,  Thomas Koehler ,  Udo Van Stevendaal ,  Matthias Bertram ,  Steffen Wiesner ,  Colas Schretter

IPC分类号： A61B6/03 ,  G01N23/04

CPC分类号： A61B6/032 ,  A61B5/107 ,  A61B6/027

摘要： A method and apparatus are provided to improve CT image acquisition using a displaced acquisition geometry. A CT apparatus may be used having a source (102) and a detector (104) transversely displaced from a center (114) of a field of view (118) during acquisition of the projection data. The amount of transverse displacement may be determined based on the size of the object (108). The source and the detector may be adjusted to vary the size of the transverse field of view. The first data set acquired by the detector may be reconstructed and used to simulate missing projection data that could not be acquired by the detector at each projection angle. The measured projection data and the simulated projection data may be used to obtain a second data set. The second data set may be compared to the first data set to produce a corrected data set.

摘要翻译： 提供了一种方法和装置，用于改善使用位移采集几何形状的CT图像采集。 可以使用CT装置，在获取投影数据期间具有从视场（118）的中心（114）横向移位的源（102）和检测器（104）。 可以基于物体（108）的尺寸来确定横向位移量。 源和检测器可以被调节以改变横向视场的大小。 由检测器获取的第一数据集可以被重构并用于模拟在每个投影角度不能由检测器获取的丢失的投影数据。 所测量的投影数据和模拟投影数据可用于获得第二数据集。 可以将第二数据集与第一数据集进行比较以产生校正数据集。

公开(公告)号：US20110150176A1

公开(公告)日：2011-06-23

申请号：US12675809

申请日：2008-09-05

申请人： Thomas Koehler ,  Rafael Wiemker

发明人： Thomas Koehler ,  Rafael Wiemker

IPC分类号： A61B6/03 ,  G06T7/00

CPC分类号： G06T7/0012 ,  G06T11/008 ,  G06T2207/10072 ,  G06T2207/30064

摘要： The invention relates to a method and an image processing device (10) for the evaluation of image raw-data of a body region generated with an imaging device like a CT scanner (30). From the image raw-data, a first image (ICAD) is reconstructed with a reconstruction module (12) according to reconstruction parameters (p) set optimally by a computer aided detection and/or diagnosis (CAD) module (13). This module can then evaluate an image (ICAD) that was reconstructed optimally according to its own requirements, for example with respect to image size and/or resolution, to find features of interest.

摘要翻译： 本发明涉及一种用于评估由诸如CT扫描仪（30）的成像装置生成的身体区域的图像原始数据的方法和图像处理装置（10）。 根据图像原始数据，根据由计算机辅助检测和/或诊断（CAD）模块（13）最佳设置的重建参数（p），利用重建模块（12）重建第一图像（ICAD）。 然后，该模块可以根据其自己的要求（例如关于图像尺寸和/或分辨率）评估被最优化地重建的图像（ICAD），以找到感兴趣的特征。

公开(公告)号：US20100272322A1

公开(公告)日：2010-10-28

申请号：US12746301

申请日：2008-12-12

申请人： Thomas Koehler

发明人： Thomas Koehler

IPC分类号： G06K9/00

CPC分类号： A61B6/032 ,  A61B6/027 ,  A61B6/5217

摘要： A CT angiography apparatus (10) compensates for respiratory motion. During a helical scan, a radiation source (16) and a detector (18) generate data sets corresponding to a plurality of sub-volumes of a blood vessel over a plurality of cardiac cycles. Sub-volume data sets corresponding to a selected cardiac phase are reconstructed (40) into a plurality of sub-volume images (54′1, 54′2, 54′3). Characteristic points (561, 562, 563) in the sub-volume images are identified. A computer routine or processor (48) calculates a respiratory motion vector based on the identified characteristic points in a plurality of the sub-volume images. An image reconstruction routine or processor (50) reconstructs the original sub-volume data (36) in the selected cardiac phase into a volume image representation (50′) using the calculated respiratory motion vector.

摘要翻译： CT血管造影装置（10）补偿呼吸运动。 在螺旋扫描期间，辐射源（16）和检测器（18）在多个心动周期上产生对应于血管的多个子体积的数据集。 对应于所选心脏相位的子体数据集被重建（40）成多个子体积图像（54'1,54'2,54'3）。 识别子体积图像中的特征点（561,562,563）。 计算机程序或处理器（48）基于多个子体积图像中所识别的特征点来计算呼吸运动矢量。 图像重建程序或处理器（50）使用所计算的呼吸运动矢量将所选择的心脏相位中的原始子体积数据（36）重建为体积图像表示（50'）。

公开(公告)号：US07778387B2

公开(公告)日：2010-08-17

申请号：US11913821

申请日：2006-05-03

申请人： Thomas Koehler ,  Claas Bontus ,  Peter Koken

发明人： Thomas Koehler ,  Claas Bontus ,  Peter Koken

IPC分类号： A61B6/00

CPC分类号： G06T11/006 ,  A61B6/027 ,  G06T2211/421

摘要： The invention relates to a method and a system for the reconstruction of an object function (f(x)) based on projections acquired during the motion of a radiation source on a helical trajectory (17). The method is particularly suited for an n-PI+ acquisition which by definition completely comprises an n-PI and additionally some overscan data from the (n+2)-PI window. According to the method, two sets (Σ≦m, Σ>m) of filtered projections are generated from the measuring values and separately back-projected to yield two absorption functions. The first absorption function (flf(x)) is based on contributions of Radon-planes with at most m intersections with the source trajectory (17), while the second absorption function (fhf(x)) is based on Radon-planes with more than m intersections with the source trajectory (17). The two absorption functions are added to yield the final absorption function (f(x)) of an object in the examination zone. In an approximative version of the method, the sets (Σ≦m, Σ>m) of filtered projections are first added and then back-projected.

摘要翻译： 本发明涉及一种用于基于在螺旋轨迹（17）上的辐射源的运动期间获取的投影来重建对象函数（f（x））的方法和系统。 该方法特别适用于n-PI +采集，其通过定义完全包括n-PI，并且另外还包括来自（n + 2）-PI窗口的一些过扫描数据。 根据该方法，从测量值产生两组滤波投影（＆Sgr;＆nlE; m，＆Sgr？m），并分别反投影以产生两个吸收函数。 第一吸收函数（flf（x））基于与源轨迹（17）最多m个交点的氡面的贡献，而第二吸收函数（fhf（x））基于具有更多的氡面 而不是与源轨迹（17）的交点。 添加两个吸收函数以产生检查区中物体的最终吸收函数（f（x））。 在方法的近似版本中，首先添加过滤投影的集合（＆Sgr;＆nlE; m，＆Sgr;> m），然后反投影。

公开(公告)号：US20100061506A1

公开(公告)日：2010-03-11

申请号：US12516356

申请日：2007-11-21

申请人： Thomas Koehler

发明人： Thomas Koehler

IPC分类号： G01D18/00 ,  A61B6/03

CPC分类号： A61B6/022 ,  A61B6/027 ,  A61B6/032 ,  A61B6/4028

摘要： The invention relates to radiation-and-detection system comprising a radiation unit (2) for alternately illuminating a detection unit (6) with radiation of a first emanating region (15) at first time intervals and with radiation of a second emanating region (16) at second time intervals, wherein first detection values are detected at the first time intervals and second detection values are detected at the second time intervals. The radiation-and-detection system is calibrated with respect to the influence of the radiation of the second emanating region (16) to the first detection values and with respect to the influence of the radiation of the first emanating region (15) to the second detection values.

摘要翻译： 本发明涉及辐射和检测系统，其包括用于以第一时间间隔和第二发射区域（16）的辐射交替地照射具有第一发射区域（15）的辐射的检测单元（6）的辐射单元（2） ），其中在第一时间间隔检测第一检测值，并且以第二时间间隔检测第二检测值。 相对于第二发射区域（16）的辐射对第一检测值的影响并且关于第一发射区域（15）的辐射对第二发射区域（15）的影响的辐射和检测系统的校准 检测值。

公开(公告)号：US20090113212A1

公开(公告)日：2009-04-30

申请号：US12248549

申请日：2008-10-09

申请人： Thomas Koehler ,  Thomas Fuchs ,  Ulrich Mayer ,  Chung-Lung Kevin Shum ,  Scott Barnett Swaney

发明人： Thomas Koehler ,  Thomas Fuchs ,  Ulrich Mayer ,  Chung-Lung Kevin Shum ,  Scott Barnett Swaney

IPC分类号： G06F21/00

CPC分类号： G06F21/72

摘要： A multiprocessor electronic circuit and an electronic data processing system comprising such circuit are disclosed for reducing the power consumption and the chip area consumption of a multiprocessor system having cryptographic functionality. In one embodiment, the multiprocessor electronic circuit comprises a plurality of processors, a single cryptographic processing unit that comprises a plurality of input/output buffer pairs and two cryptographic engines, a cipher engine and a hash engine, and associated control logic.

摘要翻译： 公开了一种包括这种电路的多处理器电子电路和电子数据处理系统，用于降低具有加密功能的多处理器系统的功耗和芯片面积消耗。 在一个实施例中，多处理器电子电路包括多个处理器，包括多个输入/输出缓冲器对和两个加密引擎，密码引擎和哈希引擎以及相关控制逻辑的单个密码处理单元。

公开(公告)号：US20090060124A1

公开(公告)日：2009-03-05

申请号：US11718718

申请日：2005-11-02

申请人： Michael Grass ,  Thomas Koehler

发明人： Michael Grass ,  Thomas Koehler

IPC分类号： H05G1/08

CPC分类号： G01T1/2985 ,  A61B6/032 ,  A61B6/4241 ,  A61B6/482 ,  A61B6/483

摘要： Interpolation of the momentum transfer prior to the filtered backprojection reconstruction in computer tomography baggage inspection or medical applications may not result in best image quality or minimal computational cost. According to an exemplary embodiment of the invention, a non-linear energy binning of an energy-resolved single-row detector is provided, which automatically leads to a Cartesian q-sampling on a parallel rebinned detector. This may avoid the q interpolation prior to the filtered back projection reconstruction, resulting in improved spatial resolution, reduction of computational effort and improved image quality.

摘要翻译： 在计算机断层摄影行李检查或医疗应用中的滤波反投影重建之前的动量传递的插值可能不会导致最佳图像质量或最小的计算成本。 根据本发明的示例性实施例，提供了能量分辨的单行检测器的非线性能量合并，其自动地在并行重新组合的检测器上导致笛卡尔q取样。 这可以避免在滤波反投影重建之前的q内插，导致改善的空间分辨率，减少计算量和改善图像质量。

公开(公告)号：US20080267344A1

公开(公告)日：2008-10-30

申请号：US12093181

申请日：2006-11-06

申请人： Thomas Koehler ,  Michael Grass

发明人： Thomas Koehler ,  Michael Grass

IPC分类号： A61B6/03

CPC分类号： A61B6/032 ,  A61B5/7289 ,  A61B6/5264

摘要： An exemplary embodiment of the invention provides a signal processing unit for producing images of an object under examination based on data signals of a tomography system, the signal processing unit comprising a processor and an input interface, wherein the input interface is adapted to receive measured data signals. Furthermore, the processor is adapted to generate a pulmonary gating signal based on said measured data signals and is further adapted to generate an image based on said measured data signals by using the pulmonary gating signal.

摘要翻译： 本发明的示例性实施例提供了一种信号处理单元，用于基于断层摄影系统的数据信号产生被检查对象的图像，信号处理单元包括处理器和输入接口，其中输入接口适于接收测量数据 信号。 此外，处理器适于基于所述测量的数据信号产生肺门控信号，并且还适于通过使用肺门控信号基于所述测量的数据信号生成图像。

公开(公告)号：US20070026423A1

公开(公告)日：2007-02-01

申请号：US11393912

申请日：2006-03-16

申请人： Thomas Koehler ,  Anne-Katrin Rost

发明人： Thomas Koehler ,  Anne-Katrin Rost

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6818 ,  C12Q1/706 ,  C12Q2565/1015 ,  C12Q2565/525 ,  C12Q2561/113 ,  C12Q2565/101

摘要： This invention concerns a method for the detection of target nucleic acids or analoga to nucleic acids (targets), wherein at least one pair of labeled oligonucleotides or analoga to oligonucleotides (probes) are used, characterised in that the upstream probe proportionally hybridises to the target with its 5′ end and proportionally hybridises to the 5′ end of the downstream probe with its 3′ end, as well as the 3′ end of the downstream probe proportionally hybridises to the target again, this resulting in a triplex structure built up between the target nucleic acid and the probe pair. This invention moreover relates to a test kit required to carry out the method.

摘要翻译： 本发明涉及用于检测靶核酸或类似物至核酸（靶）的方法，其中使用至少一对标记的寡核苷酸或类似物（寡核苷酸（探针）），其特征在于上游探针与目标物成比例地杂交 其5'端与其3'末端的下游探针的5'末端成比例地杂交，并且下游探针的3'端再次成比例地与目标杂交，导致三重结构 靶核酸和探针对。 本发明还涉及实施该方法所需的检测试剂盒。

公开(公告)号：US06984734B2

公开(公告)日：2006-01-10

申请号：US10373949

申请日：2003-02-26

申请人： Jonathan L. Sessler ,  Daniel Seidel ,  Frederic R. Bolze ,  Thomas Koehler

发明人： Jonathan L. Sessler ,  Daniel Seidel ,  Frederic R. Bolze ,  Thomas Koehler

IPC分类号： C07D245/00 ,  G02F1/035 ,  G11B7/24 ,  B32B3/26

CPC分类号： C07D487/22 ,  Y10T428/249953

摘要： The present invention provides an oxidative coupling procedure that allows efficient synthesis of novel cyclo[n]pyrrole macrocycles. Therefore, the present invention provides cyclo[n]pyrroles where n is 6, 7, 8, 9, 10, 11, or 12, and derivatives, multimers, isomers, and ion and neutral molecule complexes thereof as new compositions of matter. A protonated form of cyclo[n]pyrrole displays a gap of up to 700 nm between strong Soret and Q-like absorption bands in the electronic spectrum, demonstrating no significant ground state absorption in the visible portion of the electronic spectrum. Uses of cyclo[n]pyrroles as separation media, nonlinear optical materials, information storage media and infrared filters are provided.