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公开(公告)号:US06469144B1
公开(公告)日:2002-10-22
申请号:US08828683
申请日:1997-03-31
申请人: Avi J. Ashkenazi
发明人: Avi J. Ashkenazi
IPC分类号: C07K1600
CPC分类号: C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/70578 , C07K2319/00 , C07K2319/30 , C07K2319/40 , Y10S435/81 , Y10S435/975
摘要: Novel polypeptides, designated Apo-3 and Apo-2LI, involved in apoptosis are provided. Compositions including chimeric molecules, nucleic acids, and antibodies are also provided.
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公开(公告)号:US6030945A
公开(公告)日:2000-02-29
申请号:US584031
申请日:1996-01-09
申请人: Avi J. Ashkenazi
发明人: Avi J. Ashkenazi
IPC分类号: A01K67/027 , A61K38/00 , A61K39/395 , A61K47/48 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P43/00 , C07K14/525 , C07K14/705 , C07K16/24 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/28 , C12P21/08 , A61K38/18 , C07K14/46
CPC分类号: C07K14/70575 , A01K2217/05 , A61K38/00 , C07K2319/20 , Y10S930/14 , Y10S930/144
摘要: A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.
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公开(公告)号:US5929211A
公开(公告)日:1999-07-27
申请号:US923590
申请日:1997-09-04
IPC分类号: C07D207/44 , C07D207/452 , C07K1/107 , C07K14/805 , C07K15/14
CPC分类号: C07D207/452 , C07K1/1072 , C07K14/805 , Y10S435/96 , Y10S435/974 , Y10S436/829 , Y10S530/812
摘要: The invention provides heterobifunctional cross-linking reagents and methods of using the cross-linking reagents. The cross-linking reagents of the invention combine a nucleophilic hydrazide residue with an electrophilic maleimide residue, allowing coupling of aldehydes to free thiols. In the methods of the invention, human immunodeficiency virus (HIV) infected cells can be detected using conjugates that include CD4 molecules conjugated to detectable markers via the disclosed cross-linking reagents.
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公开(公告)号:US5889155A
公开(公告)日:1999-03-30
申请号:US415018
申请日:1995-03-31
IPC分类号: C07D207/44 , C07D207/452 , C07K1/107 , C07K14/805 , C07K15/14
CPC分类号: C07D207/452 , C07K1/1072 , C07K14/805 , Y10S435/96 , Y10S435/974 , Y10S436/829 , Y10S530/812
摘要: The invention provides heterobifunctional cross-linking reagents and methods of using the cross-linking reagents. The cross-linking reagents of the invention combine a nucleophilic hydrazide residue with an electrophilic maleimide residue, allowing coupling of aldehydes to free thiols. In the methods of the invention, human immunodeficiency virus (HIV) infected cells can be detected using conjugates that include CD4 molecules conjugated to detectable markers via the disclosed cross-linking reagents.
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公开(公告)号:US5605791A
公开(公告)日:1997-02-25
申请号:US416402
申请日:1995-03-31
IPC分类号: C07D207/44 , C07D207/452 , C07K1/107 , C07K14/805 , C12Q1/68 , C12Q1/70 , G01N33/53
CPC分类号: C07D207/452 , C07K1/1072 , C07K14/805 , Y10S435/96 , Y10S435/974 , Y10S436/829 , Y10S530/812
摘要: The invention provides heterobifunctional cross-linking reagents and methods of using the cross-linking reagents. The cross-linking reagents of the invention combine a nucleophilic hydrazide residue with an electrophilic maleimide residue, allowing coupling of aldehydes to free thiols. In the methods of the invention, human immunodeficiency virus (HIV) infected cells can be detected using conjugates that include CD4 molecules conjugated to detectable markers via the disclosed cross-linking reagents.
摘要翻译: 本发明提供异双功能交联试剂和使用交联试剂的方法。 本发明的交联试剂将亲核酰肼残基与亲电马来酰亚胺残基相结合,使醛与游离硫醇偶联。 在本发明的方法中,可以使用包含通过公开的交联试剂缀合到可检测标记的CD4分子的缀合物来检测人免疫缺陷病毒(HIV)感染的细胞。
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