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111 条记录 (耗时 0.041 秒)

    Intramolecular carbamate derivative of 2,3-Di-O-blocked-1,4-dideoxy-4-fluoro-nojirimycins
    83.
    发明授权
    Intramolecular carbamate derivative of 2,3-Di-O-blocked-1,4-dideoxy-4-fluoro-nojirimycins 失效
    2,3-二-O-封闭-1,4-二脱氧-4-氟 - 异依霉素的分子内氨基甲酸酯衍生物

    公开(公告)号：US5273981A

    公开(公告)日：1993-12-28

    申请号：US868937

    申请日：1992-04-16

    申请人： Daniel P. Getman ,  Gary A. DeCrescenzo

    发明人： Daniel P. Getman ,  Gary A. DeCrescenzo

    IPC分类号： C07D211/46 ,  C07D211/74 ,  C07D498/04 ,  A61K31/435

    CPC分类号： C07D211/46 ,  C07D211/74

    摘要： Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, alkyl radicals having from 1 to about 10 carbon atoms, alkenyl radicals having from 1 to about 10 carbon atoms, aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.

    摘要翻译： 由下式表示的新化合物：其中R表示氢，具有1至约10个碳原子的烷基，具有1至约10个碳原子的烯基，具有约6至约16个碳原子的芳基，烷芳基和芳烷基 碳原子和具有约1至约10个碳原子的酰基和酰氧基表明糖苷酶抑制活性。

    Synthesis of 1,3-dideoxy-3-fluoronojirimycin
    84.
    发明授权
    Synthesis of 1,3-dideoxy-3-fluoronojirimycin 失效
    1,3-二脱氧-3-氟苯基霉素的合成

    公开(公告)号：US5218121A

    公开(公告)日：1993-06-08

    申请号：US844335

    申请日：1992-03-02

    申请人： Daniel P. Getman ,  Gary A. DeCrescenzo

    发明人： Daniel P. Getman ,  Gary A. DeCrescenzo

    IPC分类号： C07D211/42 ,  C07D211/46 ,  C07D491/04 ,  C07D491/056 ,  C07D491/14 ,  C07F7/22

    CPC分类号： C07D491/04 ,  C07D211/42 ,  C07D211/46 ,  C07D491/14 ,  C07F7/2232

    摘要： Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, optionally substituted alkyl radicals having from 1 to about 10 carbon atoms, optionally substituted alkenyl radicals having from 1 to about 10 carbon atoms, optionally substituted aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and optionally substituted acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.

    摘要翻译： 由下式表示的新化合物：其中R表示氢，任选取代的具有1至约10个碳原子的烷基，任选取代的具有1至约10个碳原子的烯基，任选取代的芳基，烷芳基和芳烷基， 约6至约16个碳原子和任选取代的具有约1至约10个碳原子的酰基和酰氧基表明糖苷酶抑制活性。

    Glycosidase inhibiting 1,3-dideoxy-3-fluoronojirimycin
    89.
    发明授权
    Glycosidase inhibiting 1,3-dideoxy-3-fluoronojirimycin 失效
    糖苷酶抑制1,3-二脱氧-3-氟罗丹霉素

    公开(公告)号：US5130320A

    公开(公告)日：1992-07-14

    申请号：US673031

    申请日：1991-03-21

    申请人： Daniel P. Getman ,  Gary A. DeCrescenzo

    发明人： Daniel P. Getman ,  Gary A. DeCrescenzo

    IPC分类号： C07D211/42 ,  C07D211/46 ,  C07D491/04 ,  C07D491/056 ,  C07D491/14 ,  C07F7/22

    CPC分类号： C07D491/04 ,  C07D211/42 ,  C07D211/46 ,  C07D491/14 ,  C07F7/2232

    摘要： Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, optionally substituted alkyl radicals having from 1 to about 10 carbon atoms, optionally substituted alkenyl radicals having from 1 to about 10 carbon atoms, optionally substituted aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and optionally substituted acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.

    摘要翻译： 由下式表示的新化合物：其中R表示氢，任选取代的具有1至约10个碳原子的烷基，任选取代的具有1至约10个碳原子的烯基，任选取代的芳基，烷芳基和芳烷基， 约6至约16个碳原子和任选取代的具有约1至约10个碳原子的酰基和酰氧基表明糖苷酶抑制活性。

    1,3-dideoxy-3-fluoronojirimycin which inhibits glycosidase activity
    90.
    发明授权
    1,3-dideoxy-3-fluoronojirimycin which inhibits glycosidase activity 失效
    抑制糖苷酶活性的1,3-二脱氧-3-氟苯基霉素

    公开(公告)号：US5026713A

    公开(公告)日：1991-06-25

    申请号：US400252

    申请日：1989-08-29

    申请人： Daniel P. Getman ,  Gary A. DeCrescenzo

    发明人： Daniel P. Getman ,  Gary A. DeCrescenzo

    IPC分类号： C07D211/42 ,  C07D211/46 ,  C07D491/04 ,  C07D491/056 ,  C07D491/14 ,  C07F7/22

    CPC分类号： C07D491/04 ,  C07D211/42 ,  C07D211/46 ,  C07D491/14 ,  C07F7/2232

    摘要： Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, optionally substituted alkyl radicals having from 1 to about 10 carbon atoms, optionally substituted alkenyl radicals having from 1 to about 10 carbon atoms, optionally substituted aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and optionally substituted acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.

    摘要翻译： 由下式表示的新化合物：其中R表示氢，任选取代的具有1至约10个碳原子的烷基，任选取代的具有1至约10个碳原子的烯基，任选取代的芳基，烷芳基和芳烷基， 约6至约16个碳原子和任选取代的具有约1至约10个碳原子的酰基和酰氧基表明糖苷酶抑制活性。