DETECTION OF BIOAGENTS USING A SHEAR HORIZONTAL SURFACE ACOUSTIC WAVE BIOSENSOR

    公开(公告)号:US20140249042A1

    公开(公告)日:2014-09-04

    申请号:US14172429

    申请日:2014-02-04

    Abstract: Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In preferred embodiments, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV), a member of the genus Hantavirus, family Bunyaviridae, negative-stranded RNA viruses. Rapid detection (within seconds) of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, although the sensor was approximately 50×104-fold more sensitive for the detection of SNV. For both pathogens, the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1. The biosensor was able to detect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS). Further, in a proof-of-principle real world application, the SAW biosensor was capable of selectively detecting SNV agents in complex solutions, such as naturally occurring bodies of water (river, sewage effluent) without analyte pre-processing.

    Pixel snapping for anti-aliased rendering
    84.
    发明授权
    Pixel snapping for anti-aliased rendering 有权
    用于抗锯齿渲染的像素捕捉

    公开(公告)号:US08497874B2

    公开(公告)日:2013-07-30

    申请号:US11497170

    申请日:2006-08-01

    CPC classification number: G06T11/203 G09G2340/14

    Abstract: Various technologies and techniques are disclosed for improving output rendering in anti-aliased rendering scenarios. The system receives information regarding at least one visual element area which is important for symmetric appearance. The information can include at least one coordinate of a guideline that a client would like to be snapped towards a pixel grid. The system uses the information to perform a pixel snapping procedure to snap the points of visual element to a pixel grid to create an adjusted image. The adjusted image is rendered on a display device in an anti-aliased rendering scenario. APIs are provided for setting horizontal and vertical pixel snapping guidelines. The collections containing the snapping guidelines are accessed and used during the pixel snapping procedure.

    Abstract translation: 公开了各种技术和技术,用于改进抗锯齿渲染场景中的输出渲染。 系统接收关于对称外观重要的至少一个视觉元素区域的信息。 该信息可以包括客户端想要向像素网格拍摄的指南的至少一个坐标。 系统使用该信息来执行像素捕捉过程以将可视元素的点捕捉到像素网格以创建经调整的图像。 调整后的图像在抗锯齿渲染场景中在显示设备上呈现。 提供API用于设置水平和垂直像素捕捉指南。 包含捕捉指南的集合在像素捕捉过程期间被访问和使用。

    Apparatus and method for increasing flow resistance around a probe
    85.
    发明授权
    Apparatus and method for increasing flow resistance around a probe 失效
    增加探头周围流动阻力的装置和方法

    公开(公告)号:US08496631B2

    公开(公告)日:2013-07-30

    申请号:US11174935

    申请日:2005-07-05

    Applicant: David C. Brown

    Inventor: David C. Brown

    CPC classification number: A61B17/3203 A61B2017/348 A61M25/0043

    Abstract: An apparatus is provided for decreasing or eliminating flow of fluid between a probe and an incision during surgical procedures. The apparatus may comprise a deformable layer on the probe. The deformable layer may be comprised of a polymer foam, which may be covered with a surface layer. In another embodiment, baffles on a base layer are provided. The deformable layer or baffles may be on a slidable base surrounding the probe.

    Abstract translation: 提供了一种用于在外科手术过程中减少或消除探针和切口之间的流体流动的装置。 该装置可以包括探针上的可变形层。 可变形层可以由聚合物泡沫构成,聚合物泡沫可被表面层覆盖。 在另一个实施例中,提供了底层上的挡板。 可变形层或挡板可以在围绕探针的可滑动的基座上。

    Systems and methods of providing improved performance of scanning mirrors coupled to limited rotation motors
    86.
    发明授权
    Systems and methods of providing improved performance of scanning mirrors coupled to limited rotation motors 有权
    提供耦合到有限旋转电机的扫描镜的改进性能的系统和方法

    公开(公告)号:US08284470B2

    公开(公告)日:2012-10-09

    申请号:US12764392

    申请日:2010-04-21

    Abstract: A mirror is disclosed for use in a limited rotation motor system, wherein the mirror includes a body, an aperture within the body, and a high density material within the aperture. The body, formed of one or more materials, has an exposed mirror surface and is mountable with the limited rotation motor system for rotation with respect to an axis of mirror rotation. The aperture is positioned at least proximate to a portion of the axis of mirror rotation. The high density material is provided within the aperture such that it is capable of movement within the aperture, and the high density material has a density that is greater than a density of the material of the body of the mirror.

    Abstract translation: 公开了用于有限旋转马达系统的反射镜,其中反射镜包括主体,主体内的孔,以及孔内的高密度材料。 由一种或多种材料形成的主体具有暴露的反射镜表面,并且可以用有限的旋转电动机系统安装,以相对于镜子旋转轴线旋转。 孔径至少靠近反射镜旋转轴的一部分。 高密度材料设置在孔内,使得其能够在孔内移动,并且高密度材料的密度大于反射镜主体材料的密度。

    Wearable shield and self-defense device including multiple integrated components
    87.
    发明授权
    Wearable shield and self-defense device including multiple integrated components 有权
    可穿戴盾牌和自卫装置包括多个集成组件

    公开(公告)号:US08154844B2

    公开(公告)日:2012-04-10

    申请号:US12117695

    申请日:2008-05-08

    Applicant: David C. Brown

    Inventor: David C. Brown

    Abstract: A personal defense device that includes a shield member configured to be worn over at least a third of a length of a user's forearm, the forearm being bounded by the user's ipsilateral wrist and ipsilateral elbow, the length being measured from the wrist to the elbow, the shield member conforming closely to the outer surface counters of a forearm, and a portable source of electricity. The shield member includes an electrical shock bar configured to receive an electrical current from the electrical source and to deliver an electrical shock to a human or other animal.

    Abstract translation: 一种个人防护装置,其包括构造成在使用者的前臂的长度的至少三分之一上佩戴的屏蔽构件,所述前臂由使用者的同侧手腕和同侧肘部限定,所述长度从腕部到肘部被测量, 屏蔽构件紧密地与前臂的外表面计数器和便携式电源一致。 屏蔽构件包括构造成从电源接收电流并向人或其他动物传递电击的电击杆。

    PAPER CUP SEAL
    88.
    发明申请
    PAPER CUP SEAL 有权
    纸杯密封

    公开(公告)号:US20120048918A1

    公开(公告)日:2012-03-01

    申请号:US13215593

    申请日:2011-08-23

    CPC classification number: B65D3/14 B31B2105/00 B31B2105/0022 B31B2110/10

    Abstract: A paper cup having a cup side wall bonded to a portion of a paper cup bottom wherein a seal promoter is present between at least a portion of the cup side wall and a portion of the cup bottom. At least a portion of the cup side wall and a portion of the cup bottom being coated with polyethylene such that the seal promoter is applied to a portion of at least one of the polyethylene coated surfaces. The present invention is also directed to a method of producing a cup having a seal promoter applied to at least partially polyethylene treated cup side wall and/or cup bottom.

    Abstract translation: 具有与纸杯底部的一部分结合的杯侧壁的纸杯,其中在杯侧壁的至少一部分与杯底部的一部分之间存在密封促进剂。 杯侧壁的至少一部分和杯底的一部分涂覆有聚乙烯,使得密封促进剂被施加到至少一个聚乙烯涂覆表面的一部分上。 本发明还涉及一种制造杯子的方法,所述杯子具有应用于至少部分聚乙烯处理的杯侧壁和/或杯底的至少部分的密封促进剂。

    SYSTEMS AND METHODS OF PROVIDING IMPROVED PERFORMANCE OF SCANNING MIRRORS COUPLED TO LIMITED ROTATION MOTORS
    89.
    发明申请
    SYSTEMS AND METHODS OF PROVIDING IMPROVED PERFORMANCE OF SCANNING MIRRORS COUPLED TO LIMITED ROTATION MOTORS 有权
    提供与旋转电机耦合的扫描镜的改进性能的系统和方法

    公开(公告)号:US20100271679A1

    公开(公告)日:2010-10-28

    申请号:US12764392

    申请日:2010-04-21

    Abstract: A mirror is disclosed for use in a limited rotation motor system, wherein the mirror includes a body, an aperture within the body, and a high density material within the aperture. The body, formed of one or more materials, has an exposed mirror surface and is mountable with the limited rotation motor system for rotation with respect to an axis of mirror rotation. The aperture is positioned at least proximate to a portion of the axis of mirror rotation. The high density material is provided within the aperture such that it is capable of movement within the aperture, and the high density material has a density that is greater than a density of the material of the body of the mirror.

    Abstract translation: 公开了用于有限旋转马达系统的反射镜,其中反射镜包括主体,主体内的孔,以及孔内的高密度材料。 由一种或多种材料形成的主体具有暴露的反射镜表面,并且可以用有限的旋转电动机系统安装,以相对于镜子旋转轴线旋转。 孔径至少靠近反射镜旋转轴的一部分。 高密度材料设置在孔内,使得其能够在孔内移动,并且高密度材料的密度大于反射镜主体材料的密度。

    System and method for providing rotation control in a limited rotation motor system
    90.
    发明授权
    System and method for providing rotation control in a limited rotation motor system 失效
    在有限旋转电动机系统中提供旋转控制的系统和方法

    公开(公告)号:US07649288B1

    公开(公告)日:2010-01-19

    申请号:US11859843

    申请日:2007-09-24

    Applicant: David C. Brown

    Inventor: David C. Brown

    CPC classification number: H02K33/02

    Abstract: A limited rotation motor system is disclosed that includes a rotor shaft mounted within first and second bearing units. The rotor shaft is coupled to a helically shaped torsion member that is fixed with respect to a motor housing.

    Abstract translation: 公开了一种限制旋转电机系统,其包括安装在第一和第二轴承单元内的转子轴。 转子轴联接到相对于电动机壳体固定的螺旋形扭转构件。

Patent Agency Ranking