公开(公告)号：US10120136B2

公开(公告)日：2018-11-06

申请号：US15287358

申请日：2016-10-06

Applicant: GEN-PROBE INCORPORATED

Inventor： Norbert D. Hagen ,  David Opalsky

IPC: G02B6/04 ,  G02B6/36 ,  G02B6/06 ,  G02B6/08 ,  G01N21/25 ,  G01N21/64 ,  G02B6/42

Abstract: An indexing signal detection module is configured to index one or more signal detectors past each of a plurality of sources of detectable signal emissions to detect or measure a signal emitted by each source. A plurality of signal transmission conduits transmit signal emitted by the sources from a first end of each conduit to a second end of each conduit where the signal may be detected by a signal detector. A conduit reformatter is configured to secure the first ends of the respective signal transmission conduits in a first spatial arrangement corresponding to a spatial arrangement of the signal emission sources and to secure the second ends of the respective signal transmission conduits in a second spatial arrangement different from the first spatial arrangement.

公开(公告)号：US20180298427A1

公开(公告)日：2018-10-18

申请号：US16016152

申请日：2018-06-22

Applicant: Gen-Probe Incorporated

Inventor： David A. BUSE ,  David Opalsky ,  Jason F. Rhubottom ,  Norbert D. Hagen ,  Jennifer L. Tidd

IPC: C12Q1/6806 ,  C12Q1/686 ,  B01L7/00 ,  G01N35/04 ,  B01L3/00

Abstract: One or more temperature cycles are applied to the contents of a processing vial closed by an interlocked cap within a thermal cycler. The processing vial and the interlocked cap are transferred from the thermal cycler to a storage compartment within the instrument with a transfer mechanism with a probe engaged with the cap. In the storage compartment, the processing vial and interlocked cap are moved to an access opening in the instrument and are removed from the instrument through the access opening.

公开(公告)号：US20180230517A1

公开(公告)日：2018-08-16

申请号：US15951818

申请日：2018-04-12

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  David Howard Combs ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Keith Moravick ,  Tyler Moore

IPC: C12Q1/686 ,  B01L7/00

Abstract: First and second sets of receptacles containing reagents for first and second amplification reactions, respectively, are placed in first and second receptacle holders, each associated with a thermal element. The receptacles are subjected to different first and second incubation processes resulting in the first and second amplification reactions in each of the first and second sets of receptacles that contain a first or a second target nucleic acid, respectively. The presence or absence of the first or second target nucleic acid, if any, is determined for each receptacle of the first and second sets of receptacles.

公开(公告)号：US09945780B2

公开(公告)日：2018-04-17

申请号：US13912525

申请日：2013-06-07

Applicant: GEN-PROBE INCORPORATED

Inventor： Haitao Li ,  David Opalsky ,  R. Eric Heinz ,  Norbert D. Hagen

IPC: G01N21/63 ,  G01N21/64 ,  G01N21/27 ,  G01N21/62 ,  G01N21/25

CPC classification number: G01N21/645 ,  G01N21/276

Abstract: A System and method for self-checking a fluorometer for failure or deteriorated performance includes fluorescent reference standards mounted on a support to move with respect to one or more fixed fluorometers. The intensity of the fluorescent emission of the fluorescent reference standard is initially measured with the fluorometer, and, after a prescribed interval of usage of the fluorometer, a test measurement of the intensity of the fluorescent emission of the fluorescent standard is taken with the fluorometer. The test measurement is compared to the initial measurement, and failure or deteriorated performance of the fluorometer is determined based on a deviation of the test measurement from the initial measurement.

公开(公告)号：US09724693B2

公开(公告)日：2017-08-08

申请号：US14669531

申请日：2015-03-26

Applicant: GEN-PROBE INCORPORATED

Inventor： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky

IPC: B03C1/06 ,  B01L3/00 ,  G01N35/00 ,  B03C1/033 ,  B03C1/28 ,  B65B3/04 ,  B03C1/12 ,  B03C1/14 ,  B01L9/00 ,  B25J11/00 ,  C12N15/10

CPC classification number: B01L3/52 ,  B01L3/561 ,  B01L9/52 ,  B01L2300/0609 ,  B01L2300/12 ,  B03C1/0332 ,  B03C1/12 ,  B03C1/14 ,  B03C1/28 ,  B03C1/286 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  B25J11/00 ,  B65B3/04 ,  C12N15/1013 ,  G01N35/0098 ,  Y10T29/49815

Abstract: Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a portion of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.

公开(公告)号：US09465161B2

公开(公告)日：2016-10-11

申请号：US14200460

申请日：2014-03-07

Applicant: GEN-PROBE INCORPORATED

Inventor： Norbert D. Hagen ,  David Opalsky

IPC: G02B6/04 ,  G02B6/08 ,  G02B6/06 ,  G01N21/25 ,  G01N21/64 ,  G02B6/42

CPC classification number: G02B6/3668 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6484 ,  G02B6/06 ,  G02B6/08 ,  G02B6/3672 ,  G02B6/4214 ,  G02B6/4246 ,  G02B6/4269

Abstract: An indexing signal detection module is configured to index one or more signal detectors past each of a plurality of sources of detectable signal emissions to detect or measure a signal emitted by each source. A plurality of signal transmission conduits transmit signal emitted by the sources from a first end of each conduit to a second end of each conduit where the signal may be detected by a signal detector. A conduit reformatter is configured to secure the first ends of the respective signal transmission conduits in a first spatial arrangement corresponding to a spatial arrangement of the signal emission sources and to secure the second ends of the respective signal transmission conduits in a second spatial arrangement different from the first spatial arrangement.

Abstract translation: 索引信号检测模块被配置为将一个或多个信号检测器转移到多个可检测信号发射源中的每一个上，以检测或测量由每个源发射的信号。 多个信号传输管道将源发射的信号从每个管道的第一端传送到每个管道的第二端，其中信号可由信号检测器检测。 导管重新配置器被配置为以对应于信号发射源的空间布置的第一空间布置来固定各个信号传输导管的第一端，并且将相应的信号传输导管的第二端固定在不同于 第一个空间安排。

公开(公告)号：US09393565B2

公开(公告)日：2016-07-19

申请号：US14487580

申请日：2014-09-16

Applicant: GEN-PROBE INCORPORATED

Inventor： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky

IPC: B03C1/06 ,  B01L3/00 ,  G01N35/00 ,  B03C1/033 ,  B03C1/28 ,  B65B3/04 ,  B03C1/12 ,  B03C1/14 ,  B01L9/00 ,  B25J11/00

CPC classification number: B01L3/52 ,  B01L3/561 ,  B01L9/52 ,  B01L2300/0609 ,  B01L2300/12 ,  B03C1/0332 ,  B03C1/12 ,  B03C1/14 ,  B03C1/28 ,  B03C1/286 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  B25J11/00 ,  B65B3/04 ,  C12N15/1013 ,  G01N35/0098 ,  Y10T29/49815

Abstract: Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a proton of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.