公开(公告)号：US20060240036A1

公开(公告)日：2006-10-26

申请号：US11445311

申请日：2006-06-02

申请人： Jian Ni ,  Craig Rosen ,  Vishva Dixit ,  Reiner Gentz ,  Joseph Kenny

发明人： Jian Ni ,  Craig Rosen ,  Vishva Dixit ,  Reiner Gentz ,  Joseph Kenny

IPC分类号： A61K39/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06

CPC分类号： C12N9/6475 ,  A61K38/00

摘要： The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.

摘要翻译： 本发明涉及一种新型的I-FLICE-1或I-FLICE-2蛋白，其是TNFR-1和CD-95诱导的细胞凋亡的新型抑制剂。 特别地，提供编码人I-FLICE-1或I-FLICE-2蛋白的分离的核酸分子。 还提供I-FLICE-1或I-FLICE-2多肽，载体，宿主细胞和用于制备它的重组方法。 本发明还涉及用于鉴定I-FLICE-1或I-FLICE-2活性的激动剂和拮抗剂的筛选方法。 还提供了用于治疗与凋亡相关的疾病和病症的治疗方法。

公开(公告)号：US20050176044A1

公开(公告)日：2005-08-11

申请号：US11041419

申请日：2005-01-25

申请人： Jian Ni ,  Craig Rosen ,  Reiner Gentz

发明人： Jian Ni ,  Craig Rosen ,  Reiner Gentz

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/735 ,  C07K16/18 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  A61K38/17 ,  C07H21/04

CPC分类号： C07K14/70535 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70503 ,  C12N9/6421 ,  C12N9/6475 ,  C12N9/6489 ,  C12N9/6491 ,  C12N2799/026

摘要： Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.

摘要翻译： 公开了受体多肽和多核苷酸以及通过重组技术产生这种多肽的方法。 还公开了在设计用于治疗疾病的方案和用于这些病症的诊断测定中使用受体多肽和多核苷酸的方法。

公开(公告)号：US20050112090A9

公开(公告)日：2005-05-26

申请号：US10648786

申请日：2003-08-27

申请人： Jian Ni ,  Craig Rosen ,  Reiner Gentz

发明人： Jian Ni ,  Craig Rosen ,  Reiner Gentz

IPC分类号： A61K38/00 ,  A61K39/395 ,  C07K14/705 ,  C07K14/715 ,  C07K16/28 ,  A61K38/19

CPC分类号： C07K16/2878 ,  A61K38/00 ,  A61K39/39541 ,  C07K14/70578 ,  C07K14/7151 ,  C07K2319/30 ,  C12N2799/026 ,  Y02A50/412 ,  A61K2300/00

摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。 本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

公开(公告)号：US20080058247A1

公开(公告)日：2008-03-06

申请号：US11832019

申请日：2007-08-01

申请人： Jian Ni ,  Craig Rosen ,  Reiner Gentz

发明人： Jian Ni ,  Craig Rosen ,  Reiner Gentz

IPC分类号： A61K31/70 ,  A61K38/00 ,  A61P43/00 ,  C07H21/04 ,  C07K14/00 ,  C07K16/18 ,  C12N5/00 ,  G01N33/00

CPC分类号： C07K14/70535 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70503 ,  C12N9/6421 ,  C12N9/6475 ,  C12N9/6489 ,  C12N9/6491 ,  C12N2799/026

摘要： Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.

摘要翻译： 公开了受体多肽和多核苷酸以及通过重组技术产生这种多肽的方法。 还公开了在设计用于治疗疾病的方案和用于这些病症的诊断测定中使用受体多肽和多核苷酸的方法。

公开(公告)号：US20050214305A1

公开(公告)日：2005-09-29

申请号：US11010898

申请日：2004-12-14

申请人： Lu-Yuan Li ,  Yifan Zhai ,  Guo-Liang Yu ,  Jian Ni ,  Marc Lippman ,  Craig Rosen

发明人： Lu-Yuan Li ,  Yifan Zhai ,  Guo-Liang Yu ,  Jian Ni ,  Marc Lippman ,  Craig Rosen

IPC分类号： A61K38/00 ,  A61K39/395 ,  C07H21/04 ,  C07K14/705 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C07K14/70575 ,  A61K38/00 ,  A61K2039/505 ,  C07H21/04 ,  C12N2799/026 ,  G01N33/574 ,  Y02A50/407

摘要： The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.

摘要翻译： 本发明涉及能够抑制动物模型中的细胞模型中的血管生成和肿瘤发生的血管内皮细胞抑制剂VEGI及其使用方法。

公开(公告)号：US20050119457A1

公开(公告)日：2005-06-02

申请号：US10314942

申请日：2002-12-10

申请人： Jian Ni ,  Craig Rosen ,  Reiner Gentz ,  Jeffrey Su ,  Geoffrey Krissansen ,  Ping Feng

发明人： Jian Ni ,  Craig Rosen ,  Reiner Gentz ,  Jeffrey Su ,  Geoffrey Krissansen ,  Ping Feng

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/735 ,  C07K16/18 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  C07H21/04

CPC分类号： C07K14/70535 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70503 ,  C12N9/6421 ,  C12N9/6475 ,  C12N9/6489 ,  C12N9/6491 ,  C12N2799/026

摘要： The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及包含编码这种蛋白质的基因的编码区的新型人类蛋白质和分离的核酸。 还提供了用于产生本发明的蛋白质的载体，宿主细胞和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US20070015162A1

公开(公告)日：2007-01-18

申请号：US10670185

申请日：2003-09-25

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N5/06

CPC分类号： C12Q1/6883 ,  C07K14/47 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2800/24

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating allergic and asthmatic disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗过敏性和哮喘性疾病。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20060246483A1

公开(公告)日：2006-11-02

申请号：US11366486

申请日：2006-03-03

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C07K14/47 ,  C07K16/18

CPC分类号： C07K14/47

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cardiovascular diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌的多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗与之有关的心血管疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20050214209A1

公开(公告)日：2005-09-29

申请号：US10986349

申请日：2004-11-12

申请人： Theodora Salcedo ,  Steven Ruben ,  Craig Rosen ,  Vivian Albert

发明人： Theodora Salcedo ,  Steven Ruben ,  Craig Rosen ,  Vivian Albert

IPC分类号： A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  A61K51/00 ,  C07K16/46

CPC分类号： A61K39/395 ,  A61K31/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2878 ,  C07K16/30 ,  C07K2317/565 ,  C07K2317/622 ,  A61K2300/00

摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

公开(公告)号：US20050197285A1

公开(公告)日：2005-09-08

申请号：US10472533

申请日：2002-03-19

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： A61K35/76 ,  A61K38/00 ,  C07K14/47 ,  G01N33/68 ,  A61K38/17

CPC分类号： G01N33/5005 ,  A61K38/00 ,  C07K14/47 ,  G01N33/5091 ,  G01N33/68 ,  A61K35/76 ,  A61K2300/00

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating gastrointestinal diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides and also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antogonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与其有关的胃肠道疾病，病症和/或病症。 结合这些多肽并且也包括在本发明中的抗体。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明进一步包括用于鉴定本发明的多核苷酸和多肽的激动剂和亲和体的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。